This book is mainly intended for residents and young physicians in Nuclear Medicine, Oncology and Gynaecology, as well as other professionals interested in this area. It covers the application of several relevant nuclear medicine procedures for malignancies affecting the female reproductive system and the breast. To date, there has never been a nuclear medicine textbook specifically focused on this topic, which this work seeks to remedy. In recent years, certain nuclear medicine procedures have proven to be extremely valuable for the diagnosis and staging of gynaecological malignancies and breast cancer. The book provides a comprehensive and structured review of these procedures, accompanied by a summary of the respective issues, making it a valuable asset for students, instructors and practitioners alike.
Author(s): Angela Collarino, Sergi Vidal-Sicart, Renato A. Valdés Olmos
Publisher: Springer
Year: 2022
Language: English
Pages: 111
City: Cham
Foreword
Preface
Contents
1: Breast Cancer
1.1 Breast Cancer Statistics
1.2 Breast Cancer Types and Subtypes
1.3 Breast Cancer Staging
1.4 Lymphatic Drainage of the Breast
1.5 The Sentinel Node Procedure
1.6 Preoperative Sentinel Node Lymphoscintigraphy and SPECT/CT
1.7 Radiotracer Administration for Sentinel Node Mapping
1.8 Intraoperative Sentinel Node Detection
1.9 Radioguided Occult Lesion Localization
1.10 Radioguided Seed Localization
1.11 Targeted Lymph Node Biopsy: The MARI Procedure
1.12 18F-FDG and Breast Cancer
1.13 18F-FDG PET/CT to Assess Metastatic Disease in Breast Cancer
1.14 Methodological Aspects of 18F-FDG PET/CT
1.15 Breast Cancer Molecular Imaging with Non-18F-FDG PET Tracers
1.16 Dedicated Breast PET
1.17 Molecular Breast Imaging with 99mTc-sestamibi for Lesion Detection and Biopsy
1.18 New Interventional Nuclear Medicine-Based Strategies for Axillary Management
References
2: Vulvar Cancer
2.1 Vulvar Cancer Statistics
2.2 Aetiology
2.3 Anatomy
2.4 Histologic Types
2.5 Staging
2.6 Lymphatic Drainage of the Vulva
2.7 Sentinel Node Biopsy Versus Lymphadenectomy
2.8 Sentinel Node Mapping
2.8.1 Indications and Contraindications
2.8.2 Radiopharmaceuticals
2.8.3 Administered Activity and Injection Sites
2.8.4 Acquisition Protocol
2.8.5 Pitfalls in Interpretation
2.8.6 Utility of SPECT/CT
2.9 Intraoperative Sentinel Node and Pathological Evaluation
2.10 PET/CT and Vulvar Cancer
2.10.1 Indications and Contraindications
2.10.2 Acquisition Protocol
2.10.3 Image Analysis
2.10.4 Pitfalls in Interpretation
2.11 Diagnostic Utility of PET/CT
2.11.1 Staging and Therapy Planning
2.11.2 Response Assessment
2.11.3 Restaging for Suspected Recurrence
2.12 Vaginal Cancer
References
3: Cervical Cancer
3.1 Cervical Cancer Statistics
3.2 Aetiology
3.3 Anatomy
3.4 Histologic Types
3.5 Staging
3.6 Lymphatic Drainage of the Cervix
3.7 Sentinel Node Biopsy Versus Lymphadenectomy
3.8 Sentinel Node Mapping
3.8.1 Indications and Contraindications
3.8.2 Radiopharmaceuticals
3.8.3 Administered Activity and Injection Sites
3.8.4 Acquisition Protocol
3.8.5 Pitfalls in Interpretation
3.8.6 Utility of SPECT/CT
3.9 Intraoperative Sentinel Node and Pathological Evaluation
3.10 PET/CT and Cervical Cancer
3.10.1 Indications and Contraindications
3.10.2 Acquisition Protocol
3.10.3 Image Analysis
3.10.4 Pitfalls in Interpretation
3.11 Diagnostic Utility of PET/CT
3.11.1 Staging and Therapy Planning
3.11.2 Prognostic Stratification
3.11.3 Response Assessment
3.11.4 Restaging for Suspected Recurrence
References
4: Endometrial Cancer
4.1 General Aspects
4.1.1 Anatomy and Lymphatic Drainage
4.1.1.1 Routes of Spreading of Disease
4.1.2 Tumor Types
4.2 TNM-FIGO Classification
4.3 Lymphatic Mapping (Sentinel Lymph Node)
4.3.1 Pathways of Lymphatic Spread (Expected Drainage)
4.3.2 Sentinel Lymph Node Biopsy
4.4 Utility of SPECT/CT
4.5 Utility of MRI and PET/CT
4.5.1 Role of Morphologic Imaging Techniques in Staging
4.5.2 Role of Functional Imaging Techniques in Staging ([18F]FDG-PET/CT)
4.6 ROLL and/or RSL for Non-palpable Lesions Recurrence
References
5: Ovarian Cancer
5.1 General Aspects
5.1.1 Anatomy
5.1.2 Routes of Spreading of Disease
5.1.3 Tumor Types
5.1.4 FIGO and TNM Classification
5.2 Utility of CT, MR, and PET/CT
5.2.1 Role of Morphologic Imaging Techniques in Staging
5.2.2 Role of Functional Imaging Techniques in Staging ([18F]FDG PET/CT)
5.3 ROLL and/or RSL for Non-palpable Lesions Recurrences
5.4 Radioguided Seed Localization
References
