Next-Generation Biomaterials for Bone & Periodontal Regeneration

Cover
Half Title Page
Library of Congress Cataloging-in-Publication Data
Title Page
Contents
Dedication
Preface
Acknowledgments
Contributors
01: The Regenerative Properties of Bone Grafts: A Comparison Between Autografts, Allografts, Xenografts, and Alloplasts
Summary
Bone Regeneration
Autografts
Allografts
Xenografts
Alloplasts
Proportional Use of Bone Grafting Materials
Regenerative Properties of Autografts, Allografts, Xenografts, and Synthetic Alloplasts
Conclusion
References
02: Autogenous Bone: The GoldStandard for Bone Regeneration
Summary
Bone Cells: Osteoclasts, Osteoblasts, and Osteocytes
Fracture Healing and Graft Consolidation
Autogenous Bone Harvesting Techniques
Optimal Instrumentation for Autograft Harvesting
Clinical Uses and Indications for Autogenous Bone
Future Research Investigating Bone Conditioned Media
Conclusion
References
03: The Use of Allografts for Bone and Periodontal Regeneration
Summary
Biologic Background
Physical and Biologic Properties
Clinical Indications for Allografts and Case Presentations of Bone Regeneration
Key Principles
Conclusion
References
04: The Use of Xenografts in Implant Dentistry and Periodontology
Summary
Biologic Background of Nonresorbable Materials
Clinical Indications and Case Presentations Using DBBM for Bone Regeneration
Clinical Indications and Case Presentations Using DBBM for Periodontal Regeneration
Conclusion
References
05: Next-Generation Natural Bovine Bone Mineral Grafting Material with Integrated Atelocollagen Type 1
Summary
Biologic Background
Additional Literature Supporting the Use of Atelocollagen
Clinical Indications for ABBM and Presented Clinical Cases
Conclusion
References
06: Synthetic Bone Substitute Materials
Summary
Nomenclature of Synthetic Biomaterials
Biologic Background: Selecting Synthetic Materials
Resorption
Hydroxyapatite
Calcium Phosphosilicate
b-Tricalcium Phosphate
Biphasic Calcium Phosphates
Synthetic Polymers
Titanium Granules
Material Surface and Structure
Clinical Indications and Case Presentations of Bone Regeneration
Conclusion
References
07: Next-Generation Osteoinductive Synthetic Calcium Phosphates: Osopia
Summary
Modifications in the Fabrication of Synthetic Calcium Phosphates
Comparing Osopia to Autografts, Allografts, and Xenografts
Clinical Indications for Osopia
Conclusion
References
08: The Use of Autogenous Dentin Particulate Graft for Alveolar Ridge Preservation and Augmentation Following Tooth Extraction
Summary
Selecting a Scaffold for Optimal Wound Healing and Bone Deposition
Use of Extracted Tooth Dentinfor Ridge Preservation
From Extracted Tooth toAutogenous Particulate Dentin
Clinical Cases
Conclusion
References
09: Next-Generation Osteoconductive Resorbable Bone Adhesives: Tetranite
Summary
Development of Load-Bearing Bone Grafts
Composition
Mechanical Properties
Benchtop Mechanical Characterization
Exploration of Potential Dental Applications
Consequences of Exposed TN Grafts in Critical-Size Defects
Formulation Variants
Conclusion
References
10: 3D Printing Scaffolds for Alveolar Bone Augmentation
Summary
3D Printing Background
3D Bioprinting Technique
Printing Materials
Conclusion
References
11: Membranes for Guided Tissue and Bone Regeneration
Summary
Principles of Guided Tissue and Bone Regeneration
Types of Membranes for GTRand GBR
Clinical Cases Utilizing Barrier Membranes
Current Trends in the Development of Membranes
Conclusion
References
12: Autogenous Blood-Derived Barrier Membranes: Platelet-Rich Fibrin in Regenerative Dentistry
Summary
Brief History of Platelet Concentrates: From PRP to PRF
The Low-Speed Centrifugation Concept
Clinical Use of PRF and Its Indications
Conclusion
References
13: Bone Regeneration with Bone Morphogenetic Protein 2
Summary
Biologic Background
Clinical Indications for rhBMP-2
Conclusion
References
14: Enamel Matrix Derivative: Preclinical Biologic Background
Summary
Biology of Periodontal Regeneration with Enamel Matrix Proteins
Animal and Human Histologic Evidence of Periodontal Regeneration with the Use of EMD
Future Perspectives
Conclusion
References
15: Enamel Matrix Derivative: Clinical Studies
Summary
Safety of EMD
Effects on Early Wound Healing
Clinical Outcomes Following Nonsurgical Periodontal Therapy
Clinical Outcomes in Intrabony Defects
Clinical Outcomes in Recession Defects Using EMD Alone or as Adjunct to Soft Tissue Grafting
Clinical Outcomes with EMD in Furcation Defects
Clinical Treatment Guidelines for EMD
Future Research
Conclusion
References
16: Efficacy of Recombinant Human PDGF and FGF-2 for Regenerative Dentistry
Summary
Biologic Background
Supporting Literature
Clinical Indications and Cases
Conclusion
References
17: Combination Approaches for Periodontal Regeneration: Biologics, Bone Grafts, and Barrier Membranes
Summary
Biologic Agents and Growth Factors for Periodontal Regeneration
Role of Grafting Materials in Periodontal Regeneration
Role of Barrier Membranes in Periodontal Regeneration
Combination of Biologics and Grafting Materials
Combination of Biologic Agents/Growth Factors andMembranes
Combination of Grafting Materials with Membranes
Conclusion
References
18: Next-Generation Bone Morphogenetic Protein 9: The Future of Bone Regeneration?
Summary
Biologic Background: Adenovirus Transfection Experiments
Biologic Background: rhBMP Experiments
Clinical Indications for rhBMP-9
Literature Supporting the Different Pathway for BMP-9
Conclusion
References
19: Osteogain: The Next Generation of Enamel Matrix Derivative
Summary
Biologic Background and Development
Study 1: Protein Adsorption of EMD Gel Versus EMD Liquid
Study 2: Optimizing the Physicochemical Properties of EMD
Study 3: Osteogain Increases Osteoblast and PDL Cell Proliferation and Differentiation
Study 4: Gene Array of PDL Cells Exposed to Osteogain in Combination with a Bone Grafting Material
Study 5: Bone Grafting Material in Combination with Osteogain for Bone Repair
Study 6: Use of Osteogain for the Regeneration of Periodontal Tissue in Intrabony and Furcation Defects
Conclusion
References
20: Next-Generation Wound Healing with Hyaluronic Acid
Summary
Mechanism of HA Action for Wound Healing
Effect of HA on Bone Regeneration
Periodontal Regeneration with HA
Conclusion
References
21: Next-Generation Ion Incorporation into Bone Grafts for Bone and Periodontal Regeneration
Summary
The Development of Bioactive Glasses
The Mechanism for MBGRelated Bone Regeneration
Preparation of MBG
Preparation of Ions Incorporated into MBGs
Utilization and Effects of Different Therapeutic Ions
Conclusion
References
22: Next-Generation Use of Gene Therapy for Growth Factor Delivery
Summary
Biologic Background of Gene Therapy
Gene Therapy in Bone Regeneration
Target Genes
Scaffolds
Conclusion
References
23: Clinical Recommendations and Guidelines for Selecting Biomaterials for Bone and Periodontal Regeneration
Summary
Extraction Sockets
Sinus Augmentation
Guided Bone Regeneration
Immediate Implant Dentistry
Next-Generation Biomaterials for Bone Regeneration
Periodontal Regeneration o fIntrabony and Furcation Defects
Patients with Systemic Conditions
Conclusion
References
Abbreviations
Index
With contributions from
Dr Richard J. Miron
Dr Yufeng Zhang