This book contains contributions from some of the most eminent experts in the fields of genetics, biochemistry, and pathophysiology of diabetes. Through specific examples, with broad applications, this book provides a comprehensive look at how transcription factors may underline the pathogenetic mechanisms of diabetes and obesity. Volume 5 provides an overview of the status of the field, while also providing valuable information of practical utility to those who do not necessarily work in this field. The integration of basic biology with physiologically and clinically relevant proteins should provide the reader with a theoretical background to understanding the strategies for new potential therapeutic targets and their application to disease. *Applies molecular biology to transcriptional regulation of metabolism and obesity *Underscores the clinical relevance of transcription factors *Provides a valuable overview of the current status of the field
Author(s): Jacob E. Friedman (Eds.)
Series: Advances in Molecular and Cellular Endocrinology 5
Edition: 1
Publisher: Elsevier Science
Year: 2006
Language: English
Commentary: Color plates missing.
Pages: 1-309
Content:
Preface
Pages vii-viii
List of contributors
Pages ix-xii
Chapter 1 Transcription factor genes in type 2 diabetes Review Article
Pages 1-14
Michael N. Weedon, Andrew T. Hattersley, Timothy M. Frayling
Chapter 2 PPARγ, a key therapeutic target in the metabolic syndrome – unique insights derived from the study of human genetic variants Review Article
Pages 15-41
Catherine S. Mitchell, Mark Gurnell
Chapter 3 PPARδ: Emerging therapeutic potential of novel agonists in lipid and glucose homeostasis Review Article
Pages 43-62
Uwe Dressel, George E.O. Muscat
Chapter 4 Liver X receptors as potential drug targets for diabetes and its disorders Review Article
Pages 63-89,311-312
Knut R. Steffensen
Chapter 5 SREBP-1c regulation of nutrient homeostasis and lipid accumulation Review Article
Pages 91-113
Pascal Ferré, Delphine Eberlé, Bronwyn Hegarty, Fabienne Foufelle
Chapter 6 The adipocyte and adipose tissue as endocrine organs: Impact on the insulin resistance phenotype Review Article
Pages 115-141
Robert R. Henry, Susan A. Phillips, Sunder R. Mudaliar, Theodore P. Ciaraldi
Chapter 7 FOXC2 in the adipocyte Review Article
Pages 143-152,313
Sven Enerbäck
Chapter 8 Regulation of adipocyte differentiation and metabolism by Wnt signaling and C/EBP transcription factors Review Article
Pages 153-171,314
Isabelle Gerin, Hyuk C. Cha, Ormond A. MacDougald
Chapter 9 GATA proteins as molecular gatekeepers of adipogenesis Review Article
Pages 173-185,315
Judy Tsai, Qiang Tong, Gökhan S. Hotamisligil
Chapter 10 Forkhead proteins and the regulation of hepatic gene expression Review Article
Pages 187-210,316-317
Andreas Barthel, Stephan Herzig, Dieter Schmoll
Chapter 11 Disruption of CREB regulated of gene expression in diabetes Review Article
Pages 211-231,318
Jane E.B. Reusch, Peter A. Watson, Subbiah Pugazhenthi
Chapter 12 Regulation of PGC-1 in humans with insulin resistance and type 2 diabetes: Functional implications Review Article
Pages 233-253
Jussi Pihlajamäki, Mary Elizabeth Patti
Chapter 13 Hepatic CCAAT/enhancer binding protein β (C/EBPβ): engineer of diabetes, obesity, and inflammatory disease processes Review Article
Pages 255-278,319
Jill M. Schroeder-Gloeckler, Shaikh Mizanoor Rahman, Jacob E. Friedman
Chapter 14 Insulin resistance, inflammation, and the IKK/IκB/NF-κB pathway Review Article
Pages 279-302,320-321
Bankim A. Bhatt, Robert M. O’Doherty
Index
Pages 303-309
