The main purpose of this book is to bring all relevant and current advancements occurring in the field of neurobiology and neurosciences under a single window that covers wider horizons of the subject. It contains topics related to subjects like neuro-epigenetics, neuro-informatics, neurotoxicity, neurolaw, neuro-dental issues, neuro-transcriptomics, neuro-nanotechnology and more that focus on the current trends of neurosciences. Nearly all current aspects of neurosciences are covered, which makes this book a unique and comprehensive compilation. Chapter 1 defines different aspects of neuroinformatics; Chapter 2 signifies the ongoing trends related to bioinformatics in the field of neurosciences; Chapter 3 speaks about neurotoxicity; Chapter 4 is a landmark in defining the computational approaches that can be used for the identification of novel biomarkers for neurological disorders; Chapter 5 describes in detail the role of miRNA in neurobiology; Chapter 6 illustrates in detail the application of epigenetics in neurological disorders; Chapter 7 covers the details of the therapies used for the treatment of neurodegenerative diseases; Chapter 8 is confined to Alzheimer’s disease and its mitophagy, autophagy and angiogenesis; Chapter 9 discusses the role of neuro-nanotechnology in neurosurgery; Chapter 10 depicts the dental care that should be given to patients who are suffering from neurological diseases; Chapter 11 signifies the current trends prevalent in the field of oral neurosciences; and Chapter 12 is focused on the legal perspectives of neuroscience, that is, neurolaw. The coverage of subject in relation to the current trends is quite wide and the book covers a holistic approach in linearity with its title and content.
Author(s): Prachi Srivastava, Neha Srivastava, Prekshi Garg
Series: Neuroscience Research Progress
Publisher: Nova Science Publishers
Year: 2022
Language: English
Pages: 240
City: New York
Contents
Preface
Chapter 1
Bioinformatics Application and Progress in Therapeutic Interventions of Neurological Disorders
Abstract
Introduction
Computational Neurosciences and Neuroinformatics
Neuroscience Databases and Tools
Computer Aided Drug Design (CADD)
Application of CADD in Treatment of Neurological Disorders
Alzheimer’s Disease (AD)
Parkinson's Disease (PD)
Amyotrophic Lateral Sclerosis (ALS)
Huntington’s Disease (HD)
Conclusion
References
Chapter 2
Neuroinformatics: Emerging Trends of Bioinformatics in Neuroscience
Abstract
Introduction
Bioinformatics
Neuroinformatics
Neurogenomics
Database for Neuroinformatics
National Centre for Biotechnology Information (NCBI)
Neuroscience Database Gateway (NDG)
Neuroinformatics Database (NiDB)
Conclusion
References
Chapter 3
Neurotoxic Effects of Azo Food Colourants in Exposed Individuals
Abstract
Introduction
Behavioural Abnormalities
Attention Deficiency Hyperactivity Disorder (ADHD) and Other Motor Dysfunctions
Learning and Memory Deficits
Oxidative Stress-Induced Toxicity
Neurochemicals Changes
Apoptosis and Other Molecular Markers
Histopathological Changes
Conclusion
Acknowledgments
Consent for Publication
Conflict of Interest
References
Chapter 4
Identification of Novel Biomarkers for Neurological Disorders: A Computational Approach
Abstract
Introduction
Computational Approaches for Biomarker Identification
A. Multi-Omics and Neuroimaging Databases
B. Literature Mining
C. Gene Expression Analysis
D. miRNA Analysis
E. Systems Biology Approaches
F. Neuroimaging
Limitations
Conclusion
References
Chapter 5
miRNA and Mammalian Circadian Clock: A Crosstalk
Abstract
Introduction
Circadian Rhythm and Neurodegenerative Diseases: Is There a Link?
Amyotrophic Lateral Sclerosis (ALS)
Parkinson’s Disease
Alzheimer’s Disease
Conclusion and Future Outlook
References
Chapter 6
Application of Epigenetics in Neurological Disorders
Abstract
Introduction
Neurological Disorders
Neurodegenerative and Psychiatric Conditions
Alzheimer’s Disease (AD)
Frontotemporal Lobar Degeneration (FTLD)
Depression
Schizophrenia
Neurodevelopmental Disorders
Rett Syndrome (RS)
Fragile X Syndrome
Rubinstein-Taybi Syndrome
Epigenetic Mechanism
NGS Based Applications in Epigenetics
Whole Genome Bisulfite Sequencing (WGBS)
Advantages of Whole Genome Bisulfite Sequencing
MeDIP Sequencing (MeDIP-Seq)
Advantages of MeDIP Sequencing
ChIP-Seq
Advantages of ChIP-Seq
Conclusion
References
Chapter 7
Therapies for Parkinson’s Disease: Mechanisms and Current Trends
Abstract
Introduction
Therapies Targeting Intracellular Mechanism
Oxidative Stress
Protein Aggregation
Neurotransmitter Targeting
Inflammation
Therapies Promoting Neuronal Regeneration via Stem Cell
Deep Brain Stimulation (DBS)
Conclusion
References
Chapter 8
Mitophagy, Autophagy and Angiogenesis - The Collaborative Partners of Alzheimer’s Disease
Abstract
Introduction
Pathology of Alzheimer’s Disease
Neurovascular Unit Functioning in Normal Brain
Dysfunction of Neurovascular Unit in Alzheimer’s Disease
Angiogenesis and Alzheimer’s Disease
Autophagy and Mitophagy in Alzheimer’s Disease
Relation between Autophagy/Mitophagy and Angiogenesis in Alzheimer’s Disease
Conclusion
Conflict of Interest
Authors Contribution
Acknowledgments
Funding
References
Chapter 9
Neuro-Nanotechnology: A Boon to Neurosurgery
Abstract
Introduction
Nanotools for Neuroscience and Neurosurgery
Imaging Nanotools
Nanoparticles
Neuro Drug Delivery System
Nanodevices in Neurological Surgery Procedures
Conclusion
References
Chapter 10
Dental Care Associated with Patients Suffering from Neurological Disorders
Abstract
Introduction
Seizures and Epilepsy
Trauma
Periodontal Problems
Prosthodontic Problems
Dermatologic Problems
Drug Interactions
Dental Management of an Epileptic Patient
Seizure Management in Dental Clinic
Parkinson’s Disease
Dysphagia
Salivary Dysfunction
Burning Mouth
Changes in Taste and Smell
Bowel Dysfunction
Orthostatic Hypotension
Fatigue
Anxiety
Dental Management
Dementia and Alzheimer’s Disease
Treatment Planning
Stroke
Myasthenia Gravis
Dental Considerations
Facial Paralysis
Dental Considerations
Conclusion
References
Chapter 11
Current Trends in Oral Neurosciences
Abstract
Introduction: Neurologic Disorders of the Maxillofacial Region
Nerve Supply
Trigeminal Neuralgia (Tic Douloureux)
Types of Trigeminal Neuralgia
Glossopharyngeal Neuralgia
Persistent Idiopathic Facial Pain (Atypical Odontalgia/ Phantom Facial Pain/Atypical Facial Pain)
Burning Mouth Syndrome
Cluster Headache
Parkinson’s Disease (PD)
Multiple Sclerosis (MS)
Cerebral Palsy
Muscular Dystrophy
Huntington’s Disease
Myasthenia Gravis
Dysphagia
Hypoglossal Nerve Injury
Bell’s Palsy
Conclusion
References
Chapter 12
Neurolaw: The Legal Perspective of Neuroscience
Abstract
Introduction
The Intersection of Neuroscience and Law: Neurolaw
The Intersection of Neurosciences and Criminal Laws
Neurolaw Research Domains
Revision
Assessment
Intervention
A Reflection on Two Main Types of Research in Neurolaw
Practical Researches
Theoretical Researches
Contribution of Neurolaw to Judiciary
Brain Electrical Oscillation Signature Profiling (BEOSP) Evidentiary Value
Applicability of Neuroscience in Courtroom
Some of the Encountering Questions That Are Faced by the Neurolawyers
Other Law and Neuroscience Issues Beyond Criminal Responsibility
Opportunities in Neurolaw
Challenges in Neurolaw
Overenthusiasm
Overcriticism
Scope of Neurolaw in Future
Conclusion
References
Editors’ Contact Information
Index
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