This book is a representative survey of the current status of the structure, function, regulation and molecular pharmacology of Neurotransmitter Transporters. It provides an overview of insights generated in the past five years. The volume serves as a useful compendium of current concepts and an inspiring starting point. It is a source for students interested in this emerging field as well as for experienced scientists looking for an update.
Author(s): Harald H. Sitte, Michael Freissmuth
Edition: 1
Year: 2006
Language: English
Pages: 561
List of Contents......Page 7
Zn[sup(2+)] Modulation of Neurotransmitter Transporters......Page 10
Molecular Microfluorometry: Converting Arbitrary Fluorescence Units into Absolute Molecular Concentrations to Study Binding Kinetics and Stoichiometry in Transporters......Page 32
Structure/Function Relationships in Serotonin Transporter: New Insights from the Structure of a Bacterial Transporter......Page 67
The Importance of Company: Na[sup(+)] and Cl[sup(–)] Influence Substrate Interaction with SLC6 Transporters and Other Proteins......Page 82
Currents in Neurotransmitter Transporters......Page 101
Mutational Analysis of Glutamate Transporters......Page 118
The Diverse Roles of Vesicular Glutamate Transporter 3......Page 141
Extraneuronal Monoamine Transporter and Organic Cation Transporters 1 and 2: A Review of Transport Efficiency......Page 155
The Role of SNARE Proteins in Trafficking and Function of Neurotransmitter Transporters......Page 185
Regulation of the Dopamine Transporter by Phosphorylation......Page 201
The Dopamine Transporter: A Vigilant Border Control for Psychostimulant Action......Page 219
Oligomerization of Neurotransmitter Transporters: A Ticket from the Endoplasmic Reticulum to the Plasma Membrane......Page 237
Acute Regulation of Sodium-Dependent Glutamate Transporters: A Focus on Constitutiveand Regulated Trafficking......Page 254
Regulation and Dysregulation of Glutamate Transporters......Page 279
Regulation of Vesicular Monoamine and Glutamate Transporters by Vesicle-Associated Trimeric G Proteins: New Jobs for Long-Known Signal Transduction Molecules......Page 306
Human Genetics and Pharmacology of Neurotransmitter Transporters......Page 327
ADHD and the Dopamine Transporter: Are There Reasons to Pay Attention?......Page 372
Inactivation of 5HT Transport in Mice: Modeling Altered 5HT Homeostasis Implicated in Emotional Dysfunction, Affective Disorders, and Somatic Syndromes......Page 415
Lessons from the Knocked-Out Glycine Transporters......Page 455
The Norepinephrine Transporter in Physiology and Disease......Page 482
The High-Affinity Choline Transporter: A Critical Protein for Sustaining Cholinergic Signaling as Revealed in Studies of Genetically Altered Mice......Page 522
A......Page 542
D......Page 543
G......Page 544
I......Page 545
N......Page 546
P......Page 547
S......Page 548
Z......Page 549
