The scope of Neuromuscular Pathology continuous to expand, as evidenced by the numerous multivolume and speciality texts published in recent years. This short textbook provides a complete overview of both clinical and histological aspects of common and rare neuromuscular diseases. The objective is twofold: to provide information about neuromuscular diseases in a simplified, integrated, and rapidly accessible format suited to those initially encountering the discipline, and also to provide a clear approach using simple pictures, tables and algorithms to illustrate histological features in muscle and nerve biopsy.
This volume is conveniently divided into three sections with a total of 30 chapters. The first section deals with basic principles of neuromuscular histology and physiology, processing technique, histochemistry, and laboratory management. The second and third sections deal with neuromuscular diseases that are summarized in a stepwise approach, complemented by algorithms and organized tables.
A simplified, integrated, and rapidly accessible format covering both common and rare neuromuscular diseases
Clear simple illustrations, organized tables and algorithms to aid the reader in finding an easy approach to accurate diagnosis
Practical tips to facilitate histopathological diagnosis.
Clinical scenarios discussing common neuromuscular conditions
Neurologists, neuropathologists, trainees and medical students involved in clinical neuroscience and pathology will find this guide of practical benefit in both education and practice.
Author(s): Maher Kurdi
Edition: 1
Publisher: CRC Press
Year: 2021
Language: English
Tags: Neurology; Pathology; Neuromuscular Diseases; Rheumatology; Clinical Neuroscience; Neuropathology
Cover
Half Title
Title Page
Copyright Page
CONTENTS
List of Contributors
Preface
Acknowledgment
Abbreviations
Part I: General
Chapter 1: Muscle and Nerve Histology
1.1. Muscle Histology
1.1.1. Mitochondria
1.2. Peripheral Nerve Histology
Chapter 2: Muscle and Nerve Fibers Classification
2.1. Muscle Fiber Classification
2.2. Peripheral Nerve Fiber Classification
Chapter 3: Clinical Neurophysiology
3.1. Nerve Conduction Study (NCS)
3.2. Electromyography (EMG)
Chapter 4: Neuromuscular Laboratory
Chapter 5: Chemical Materials Used in the Lab
Chapter 6: Biopsy Processing Protocol
6.1. Muscle
6.1.1. Selection of Muscle
6.1.2. Muscle Biopsy Surgical Options
6.1.3. Muscle Specimen Preparation
6.2. Nerve
6.2.1. Nerve Selection
6.2.2. Nerve Specimen Preparation
Chapter 7: Histochemistry Protocol
7.1. Histochemical Reaction
7.2. Histochemistry Protocol
7.3. Immunohistochemistry (IHC)
7.4. Histological Artifacts
Chapter 8: Genetic Basis Of Neuromuscular Disorders
8.1. Single or Multiple Gene Approach
8.2. Whole-Exome and Whole-Genome
8.3. RNA Sequencing
Chapter 9: Neuromuscular Final Report
9.1. Muscle Biopsy Report Template
9.2. Nerve Biopsy Report Template
Part II: Muscle
Chapter 10: Initial Approach in Muscle Biopsy
10.1. Myopathic Features
10.2. Neuropathic Features
10.3. Dystrophic Features
Chapter 11: Differential Diagnosis
Chapter 12: Electron Microscopy
Chapter 13: Classification of Myopathy
Chapter 14: Approach to Neuromyopathy
14.1. Neuromyopathy with Lack of Inflammation
14.1.1. Paraneoplastic-Induced Neuromyopathy
14.1.2. Drug-Induced Neuromyopathic Change
14.2. Neuromyopathy with Inflammation
Chapter 15: Approach to Vacuolar Myopathy
Chapter 16: Muscular Dystrophy Diseases
Chapter 17: Inherited Myopathic Diseases
Chapter 18: Non-Congenital Acquired Myopathies
18.1. Chronic Disease-Induced Myopathies
18.2. Toxic Myopathies
18.2.1. Statin-Induced Myopathy
18.3. Critical Care Illness Myopathy
Chapter 19: Metabolic Myopathy
19.1. Glycogen Storage Diseases (GSD, Glycogenosis)
19.1.1. Pompe Disease
19.2. Lipid Storage Diseases
19.3. Mitochondrial Myopathies (MM)
19.4. Other Metabolic Myopathies
19.4.1. Amyloid Myopathy
Chapter 20: Inflammatory Myopathy
20.1. Polymyositis (PM, Adermatopathic Myositis)
20.2. Dermatomyositis (DM)
20.3. Immune-Mediated Necrotizing Myopathy (IMNM)
20.4. Overlap Myositis (OM)
20.5. Inclusion Body Myositis (IBM)
20.6. Granulomatous Myositis
20.7. Treated Myositis in Muscle Biopsy
Chapter 21: Chronic Denervation Myopathy
21.1. Chronic Denervation Atrophy (CDA)
21.2. Spinal Muscular Atrophy (SMA)
Chapter 22: Axial Myopathy
Chapter 23: Fasciitis
Part III: Nerve
Chapter 24: Classification of Neuropathy
Chapter 25: Diagnostic Approach in Nerve
Chapter 26: Axonal Neuropathy
Chapter 27: Demyelinating Neuropathy
Chapter 28: Cellular and Extracellular Abnormalities
Chapter 29: Inflammatory Demyelination
29.1. Acute Inflammatory Demyelinating Neuropathy
(AIDN)—Guillain–Barré Syndrome (GBS)
29.2. Chronic Inflammatory Demyelinating Neuropathy (CIDN)
Chapter 30: Other Common Peripheral Neuropathies
Index
