Univ. of California, Los Angeles Mental Retardation Research Center. Discusses the role of glial cells in normal aging and in pathological aging, i.e, neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases. Covers cellular and molecular changes of aged and reactive astrocytes, and more. DNLM: Brain--cytology.
Author(s): Jean de Vellis
Series: Contemporary Neuroscience
Edition: 1st
Publisher: Humana Press
Year: 2002
Language: English
Pages: 529
Foreword by Paola Timiras......Page 6
Preface......Page 8
Contributors......Page 12
PART I: CELLULAR AND MOLECULAR CHANGES OF AGED AND REACTIVE ASTROCYTES......Page 16
1 Neuromorphological Changes in Neuronal and Neuroglial Populations of the Cerebral Cortex in the Aging Rat: Neurochemical Correlations......Page 18
2 Diversity in Reactive Astrocytes......Page 32
3 Astrocytic Reaction After Traumatic Brain Injury......Page 50
PART II: NEURON–GLIA INTERCOMMUNICATION......Page 72
4 Astrocytes In Situ Exhibit Functional Neurotransmitter Receptors......Page 74
5 Glia and Extracellular Space Diffusion Parameters in the Injured and Aging Brain......Page 92
6 Intercellular Diffusional Coupling between Glial Cells in Slices from the Striatum......Page 114
7 Glial Cell Involvement in Brain Repair and the Effects of Aging......Page 128
8 ATP Signaling in Schwann Cells......Page 150
PART III: NEUROTROPHINS, GROWTH FACTORS, AND NEUROHORMONES IN AGING AND REGENERATION......Page 170
9 Gliosis Growth Factors in the Adult and Aging Rat Brain......Page 172
10 Role of Fibroblast Growth Factor-2 in Astrogliosis......Page 194
11 Trophins as Mediators of Astrocyte Effects in the Aging and Regenerating Brain......Page 214
12 Responses in the Basal Forebrain Cholinergic System to Aging......Page 232
13 Effects of Estrogens and Thyroid Hormone on Development and Aging of Astrocytes and Oligodendrocytes......Page 260
PART IV: METABOLIC CHANGES......Page 272
14 Neurotoxic Injury and Astrocytes......Page 274
15 Ammonium Ion Transport in Astrocytes: Functional Implications......Page 290
PART V: ASTROCYTES AND THE BLOOD-BRAIN BARRIER IN AGING......Page 304
16 Molecular Anatomy of the Blood-Brain Barrier in Development and Aging......Page 306
17 The Blood-Brain Barrier in the Aging Brain......Page 320
18 Astrocytes and Barrier-provided Microvasculature in the Developing Brain......Page 336
PART VI: ASTROCYTES IN NEURODEGENERATIVE DISEASES......Page 352
19 Microglial and Astrocytic Reactions in Alzheimer’s Disease......Page 354
20 Activated Neuroglia in Alzheimer’s Disease......Page 380
21 Reactive Astroglia in the Ataxic Form of Creutzfeldt-Jakob Disease: Cytology and Organization in the Cerebellar Cortex......Page 390
22 Ischemic Injury, Astrocytes, and the Aging Brain......Page 408
23 Glial-Neuronal Interactions during Oxidative Stress: Implications for Parkinson’s Disease......Page 422
24 Astrocytic Changes Associated with Epileptic Seizures......Page 436
25 Synaptic and Neuroglial Pathobiology in Acute and Chronic Neurological Disorders......Page 458
26 Astrocytes and Ammonia in Hepatic Encephalopathy......Page 492
Index......Page 512
