Research on young individuals and childbearing adults being treated for neoplasia has revealed a rising number of requests for treatments aimed to maintain the possibility to conceive. To answer such requests, it is important for medical professionals to consider the necessity to cure the woman, to preserve her fertility, to give information both on the effect of neoplasia and treatments on pregnancy. Patients have to be informed on the possible treatment alternatives that are less aggressive towards the reproductive function, but at the same time, give desirable results in terms of survival.
Neoplasia and Fertility describes the state-of-the-art on fertility preservation in women affected by neoplasia. The 11 book chapters inform the reader with the goal of equipping them with the required information needed to present the condition and to discuss the possibility of conceiving, and how to manage patients after oncologic treatments at different stages of pregnancy.
Key Features
- Informs the reader about the relationship between gynecological cancer and fertility in women through 11 chapters
- Describes a broad range of cancers and relevant treatment options for maintaining fertility
- Explains the role of a ‘Fertility Sparing Team’ in clinics
- Familiarizes the reader with the ethics behind oncology treatments with reference to female fertility
- Describes fertility issues related to hereditary cancers in women
- Includes references for further reading
The book serves as an informative reference on the subject to medical doctors in the gynecology, obstetrics and midwife specialties, and nurses training the gynecological oncology. It will also be of interest to healthcare administrators involved in fertility and oncology clinics, as well as general practitioners in family medicine.
Author(s): Cesare Romagnolo, Tiziano Maggino
Publisher: Bentham Science Publishers
Year: 2022
Language: English
Pages: 230
City: Singapore
Cover
Title
Copyright
End User License Agreement
Contents
Preface
List of Contributors
Fertility Preservation and Cervical Cancer: Fertility-Sparing Surgery and Cervical Cancer in Pregnancy
Lorenzo Ceppi1,2, Tommaso Grassi1,2, Robert Fruscio1,2, Eleonora Preti3 and Fabio Landoni1,2,*
CERVICAL CANCER AND FERTILITY SPARING SURGERY
Introduction
Fertility-Sparing Surgery
FIGO Stage IA
FIGO Stage IB
Clinical and Histological Characteristics Evaluation
Choice of Fertility Sparing Surgery technique
FIGO Stage IB1 and Tumor Size < 2.0 cm (2018 FIGO Stage IB1)
FIGO Stage IB1 and Tumor Size > 2.0 cm (2018 FIGO Stage IB2)
FIGO Stage IB2 e IIA (2018 FIGO stage IB3 or IIA)
Sentinel Lymph Node (SLN)
Fertility, Live Birth, Prematurity Outcomes
Overall Fertility
Live Birth and Prematurity
CERVICAL CANCER DURING PREGNANCY
Epidemiology
Diagnosis and Staging
PAP Smear Management
Diagnostic Procedures in Pregnant Patients
Therapeutic Options
Non-Invasive Disease
Invasive Disease
Treatment Timing
Delivery Modalities
Effects of Pregnancy on Cervico-Carcinoma
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Endometrial Cancer and Fertility
Angiolo Gadducci1,* and Roberta Tana1
INTRODUCTION
Fertility-sparing Therapy of Young Women With Endometrial Complex Atypical Hyperplasia or Endometrioid Carcinoma
Pregnancy Outcome in Young Women With Endometrial Complex Atypical Hyperplasia or Endometrioid Carcinoma Treated With Fertility-Sparing Therapy
CONCLUSIONS
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Fertility-Sparing Surgery in Eptelial Ovarian Cancers
Tiziano Maggino1,*
GENERAL CONSDERATIONS
SURGICAL STAGING
MANAGING A SUSPECTED ADNEXAL MASS IN CHILDBEARING AGE
FERTILITY-SPARING SURGERY: ONCOLOGIC OUTCOME
FERTILITY OUTCOME
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Breast Cancer and Pregnancy
P. Zola1, C. Macchi1,*, G. Parpinel1, B. Masturzo2, M. Laudani1, E. Potenza1 and M. Mitidieri3
INTRODUCTION
EPIDEMIOLOGY
DIAGNOSIS
Clinical Examination
Imaging
Cyto-Histological Diagnosis
Biomarkers
STAGING
MANAGEMENT
Surgery
Radiotherapy
Chemotherapy
Hormone Therapy
Supportive Therapy
PRENATAL CARE
PROGNOSIS
BIRTH CONTROL
PREGNANCY AFTER BREAST CANCER
CONCLUSIONS
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Non-Gynecologic Tumors and Fertility Melanoma
Cesare Romagnolo1,*
INTRODUCTION
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Non-Gynecologic Tumors and Fertility Thyroid
Cesare Romagnolo1,*
INTRODUCTION
THYROID DISEASE IN PREGNANCY
THYROID CARCINOMA
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Fertility Sparing Team
Enrico Sartori1,*, Franco E. Odicino1, Federico Ferrari2 and Valentina Zizioli2
INTRODUCTION
OBJECTIVES
PRINCIPLES
Principles During Surgical Procedures
Principles During Medical Treatment (Chemotherapy)
Principles of Radiotherapy
Final Consideration of Principles
MEMBERS OF FERTILITY-SPARING TEAM
Medical Figures
Non-medical Figures
DESIGN OF FERTILITY PRESERVATION CONSULTATION
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Gametes and Embryos Cryopreservation in Oncologic Patients
E. Antonini1,* and B. Engl1
INTRODUCTION
Oocyte Cryopreservation
Spermatozoa Cryopreservation
Embryos Cryopreservation
Ovarian Parenchymal Tissue
CONCLUSIONS
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Ovarian Protection During Chemo- and Radio-Therapy
Monica Della Martina1, Giulia Trombetta1, Martina Venier1 and Angelo Cagnacci2,*
INTRODUCTION
Ovarian Protection During Chemotherapy
Breast Cancer
Hematological Neoplasms
Protection During Radiotherapy
Ovarian Transposition
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Hormonal Replacement Therapy After Neoplasia Treatment
Monica Della Martina1, Martina Venier1, Giulia Trombetta1 and Angelo Cagnacci2,*
INTRODUCTION
UTERINE CANCER
BREAST CANCER
OVARIAN CANCER
CERVICAL CANCER
VULVA/VAGINAL CANCER
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Fertility Issues in Hereditary Gynecological Malignancies
Lino Del Pup1,* and Fedro A Peccatori2
INTRODUCTION
METHODS
FERTILITY COUNSELING IN BRCA PATIENTS: INFORMING THE POSSIBLE FERTILITY EFFECTS, PREMATURE MENOPAUSE AND FERTILITY OPTIONS
BRCA1/2 MUTATION CARRIERS SEEM TO BE AS FERTILE AS NON-CARRIERS
BRCA CARRIERS COULD HAVE AN ABNORMAL RESPONSE TO OVARIAN STIMULATION, BUT THE JURY IS STILL OUT
BRCA1 MUTATION CARRIERS SEEM TO HAVE A LOWER LEVEL OF MARKERS OF OVARIAN RESERVE (AMH)
BRCA1/2 MUTATION CARRIERS COULD HAVE A PREMATURE MENOPAUSE
BREAST CANCER RISK IN BRCA1 MUTATION CARRIERS DECREASES WITH INCREASING AGE AT FIRST BIRTH
AMONG BRCA2 CARRIERS, INCREASED PARITY MIGHT BE ASSOCIATED WITH AN INCREASE IN PREMENOPAUSAL BREAST CANCER RISK
BRCA 1-2 MUTATIONS INCREASE THE RISK OF CANCER BEFORE PARENTHOOD
CHEMOTHERAPY SEEMS TO INDUCE MORE AMENORRHEA AND PREMATURE MENOPAUSE IN BRCA2 CARRIERS
BRCA1/2 MUTATION CARRIERS WITH ENDOCRINE RESPONSIVE BREAST CANCERS HAVE AN ADDITIONAL REPRODUCTIVE RISK DUE TO TAMOXIFEN ADMINISTRATION
BRCA1/2 MUTATION CARRIERS ARE CANDIDATES FOR PROPHYLACTIC OOPHORECTOMY, WHICH REDUCES THE “REPRODUCTIVE WINDOW OF OPPORTUNITY”
SYSTEMATIC FERTILITY PRESERVATION IN HEALTHY BRCA CARRIERS SHOULD BE DISCUSSED, BUT QUESTIONS REMAIN
SPECIFIC RISKS OF OVARIAN STIMULATION ARE NOT WELL KNOWN, AND LETROZOLE COULD BE A GOOD OPTION
CRYOPRESERVATION OF THE OVARIAN CORTEX IS NOT SAFE IN BRCA CARRIERS
IN VITRO OOCYTE MATURATION COULD BE USEFUL, BUT IT IS STILL EXPERIMENTAL
PROPHYLACTIC FIMBRIECTOMY IS STILL EXPERIMENTAL BUT PROMISING IN REDUCING OVARIAN CANCER RISK WHILE MAINTAINING OVARIAN FUNCTION
LYNCH SYNDROME AND FERTILITY COUNSELING: PROMOTE EARLY GESTATION, HORMONAL CONTRACEPTION, SURVEILLANCE AND PROPHYLACTIC HYSTERECTOMY AFTER PARITY
PROMOTE EARLY AND MULTIPLE PARITY AS IT REDUCES ENDOMETRIAL AND OVARIAN CANCER RISK
OFFER HORMONAL CONTRACEPTION TO REDUCE ENDOMETRIAL AND OVARIAN CANCER RISK BEFORE, BETWEEN, AFTER OR AS AN ALTERNATIVE TO PREGNANCIES
LEVONORGESTREL IUS REDUCES ENDOMETRIAL CANCER RISK, BUT THE EFFECT ON OVARIAN CANCER RISK IS STILL CONTROVERSIAL
GYNECOLOGICAL SURVEILLANCE MAY LEAD TO EARLIER DETECTION OF PRECANCEROUS LESIONS, BUT IT COULD LEAD TO INVASIVE PROCEDURES BECAUSE OF FALSE-POSITIVE RATES
DISCUSS PROPHYLACTIC HYSTERECTOMY AFTER COMPLETING CHILDBEARING AS THE ONLY CONSENSUS RECOMMENDATION FOR REDUCING ENDOMETRIAL CANCER
CONCLUSIONS
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Subject Index
