Natural killer (NK) cells have been at the forefront of immunology for two decades. During that time, a great amount of information about these cells has been obtained. They are important in antiinfectious and antitumoral defense and shape the adaptive immune response. In addition, they can act as immunoregulatory cells. In recent years, the therapeutic potential of NK cells in cancer immunotherapy has become increasingly evident. This book describes in detail current knowledge about NK cells and covers a broad range of NK cell-related topics, including those that are not frequently reviewed, e.g. NK cells and allergy or NK cells and skin diseases.
Author(s): Vicente P. C. Peixoto de Toledo, Renato Sathler-Avelar (auth.), Jacques Zimmer (eds.)
Edition: 1
Publisher: Springer-Verlag Berlin Heidelberg
Year: 2010
Language: English
Pages: 428
Tags: Immunology; Human Physiology; Biomedicine general
Front Matter....Pages i-xi
Natural Killer Cells: Deciphering Their Role, Diversity and Functions....Pages 1-38
Dissecting Human NK Cell Development and Differentiation....Pages 39-61
Diversity of KIR Genes, Alleles and Haplotypes....Pages 63-91
NK Cell Education and CIS Interaction Between Inhibitory NK Cell Receptors and Their Ligands....Pages 93-108
Trogocytosis and NK Cells in Mouse and Man....Pages 109-123
Virus Interactions with NK Cell Receptors....Pages 125-152
The Role of NK Cells in Bacterial Infections....Pages 153-175
NK Cells and Autoimmunity....Pages 177-190
NK Cells and Allergy....Pages 191-198
Natural Killer Cells and Their Role in Hematopoietic Stem Cell Transplantation....Pages 199-219
NK Cells, NKT Cells, and KIR in Solid Organ Transplantation....Pages 221-239
NK Cells in Autoimmune and Inflammatory Diseases....Pages 241-254
Natural Killer Cells and the Skin....Pages 255-266
NK Cells in Oncology....Pages 267-274
The Role of KIR in Disease....Pages 275-298
Interactions Between NK Cells and Dendritic Cells....Pages 299-313
Modulation of T Cell-Mediated Immune Responses by Natural Killer Cells....Pages 315-327
Interactions Between NK Cells and Regulatory T Cells....Pages 329-343
Interactions Between B Lymphocytes and NK Cells: An Update....Pages 345-368
The Regulatory Natural Killer Cells....Pages 369-389
NK Cells and Microarrays....Pages 391-404
Natural Killer Cells in the Treatment of Human Cancer....Pages 405-421
Back Matter....Pages 423-428