This book takes a systematic approach to nanotoxicology and the developing risk factors associated with nanosized particles during manufacture and use of nanotechnology. Beginning with a detailed introduction to engineered nanostructures, the first part of the book presents concepts and definitions of nanomaterials from quantum dots to graphene to fullerenes, with detailed discussion of functionalization, stability, and medical and biological applications. The second part critically examines methodologies used to assess cytotoxicity and genotoxicity. Coverage includes interactions with blood (erythrocytes), combinatorial and microarray techniques, cellular mechanisms, and ecotoxicology assessments. Part three describes cases studies both in vitro and in vivo for specific nanomaterials including solid lipid nanoparticles and nanostructured lipid carriers and metallic nanoparticles and metallic oxides. New information is also presented on toxicological aspects of poloxamers and polymeric nanoparticles as drug carriers as well as size effects on cytotoxicity and genotoxicity. Didactic aspects are emphasized in all chapters, making the book suitable for a broad audience ranging from advanced undergraduate and graduate students to researchers in academia and industry. In all, Nanotoxicology: Materials, Methodologies, and Assessments will provide comprehensive insight into biological and environmental interactions with nanostructures.
- Provides an introduction to nanostructures actually in use
- Describes cyto- and genotoxicity methodologies, and assesses their performance in comparison to common toxicity assays
- Discusses the relation of cytotoxicity and genotoxicity to ecotoxicity
- Presents a range of applications, from biogenic silver nanoparticles to poloxamers as drug-delivery systems, reflecting the expanding applications of nanotechnology
Author(s): Oswaldo L. Alves, Ana Carolina Mazarin de Moraes, Mateus Batista Simões (auth.), Nelson Durán, Silvia S. Guterres, Oswaldo L. Alves (eds.)
Series: Nanomedicine and Nanotoxicology
Edition: 1
Publisher: Springer-Verlag New York
Year: 2014
Language: English
Pages: 411
Tags: Pharmacology/Toxicology;Nanochemistry;Ecotoxicology;Nanotechnology;Nanoscale Science and Technology
Front Matter....Pages i-xv
Nanomaterials....Pages 1-29
Concepts and Methodology of Interaction of Carbon Nanostructures with Cellular Systems....Pages 31-55
Nanostability....Pages 57-95
Pharmacokinetics and Pharmacodynamics of Nanomaterials....Pages 97-110
In Vitro Cytotoxicity Assays of Nanoparticles on Different Cell Lines....Pages 111-123
Carbon Nanotubes: From Synthesis to Genotoxicity....Pages 125-152
From Combinatorial Display Techniques to Microarray Technology: New Approaches to the Development and Toxicological Profiling of Targeted Nanomedicines....Pages 153-175
Genetic Studies on the Effects of Nanomaterials....Pages 177-199
Cellular Mechanisms in Nanomaterial Internalization, Intracellular Trafficking, and Toxicity....Pages 201-227
Cytotoxicity and Genotoxicity of Solid Lipid Nanoparticles....Pages 229-244
Cytotoxicity and Genotoxicity of Biogenically Synthesized Silver Nanoparticles....Pages 245-263
Cytotoxicity and Genotoxicity of Iron Oxides Nanoparticles....Pages 265-279
Poloxamers as Drug-Delivery Systems: Physicochemical, Pharmaceutical, and Toxicological Aspects....Pages 281-298
Polymeric Nanoparticles: In Vivo Toxicological Evaluation, Cardiotoxicity, and Hepatotoxicity....Pages 299-324
Cyto-, Geno-, and Ecotoxicity of Copper Nanoparticles....Pages 325-345
Assessing the Erythrocyte Toxicity of Nanomaterials: From Current Methods to Biomolecular Surface Chemistry Interactions....Pages 347-361
Toxicity of Nanomaterials to Microorganisms: Mechanisms, Methods, and New Perspectives....Pages 363-405
Back Matter....Pages 407-411
