A huge effort is put into the science of nanoparticles and their production. In many cases it is unavoidable that nanoparticles are released into the environment, either during the production processes or during the use of a product made from these particles. It is also realized that combustion processes like traffic and power plants release nanoparticles into the atmosphere. However it is not known how nanoparticles interact with the human body, especially upon inhalation. At the same time research activities are devoted to understand how nano-sized medicine particles can be used to administer medicines via inhalation. In any case it is absolutely necessary to know how the nanoparticles interfere with the inhalation system, how they deposit and affect on the human system.
Three main themes are discussed:
- Nanoparticle sources and production
- Nanoparticle inhalation and deposition
- Toxicological and medical consequences of nanoparticles
Each theme is covered comprehensively, starting at nano-quantum effects up to technical and medical applications such as measuring equipment and inhalation instrumentation. This book brings together all sub-disciplines in the field related to aerosol nanoparticles. Each chapter is written by a world expert, giving the state of the art information and challenging open questions. The last chapter summarizes in an interdisciplinary way what is already known and what still is ahead of us.
Author(s): Heinz Burtscher (auth.), J.C. Marijnissen, Leon Gradon (eds.)
Edition: 1
Publisher: Springer Netherlands
Year: 2010
Language: English
Pages: 287
Tags: Biomedicine general; Nanotechnology and Microengineering; Public Health/Gesundheitswesen; Environmental Health; Pharmacology/Toxicology
Front Matter....Pages i-xi
The Origin and Production of Nanoparticles in Environment and Industry....Pages 1-17
Characterization of Combustion and Engine Exhaust Particles....Pages 19-37
Medicine Nanoparticle Production by EHDA....Pages 39-57
Electrospray and Its Medical Applications....Pages 59-75
Generation of Nanoparticles from Vapours in Case of Exhaust Filtration....Pages 77-89
Measurement and Characterization of Aerosol Nanoparticles....Pages 91-112
Inhalation and Deposition of Nanoparticles: Fundamentals, Phenomenology and Practical Aspects....Pages 113-144
Dosimetry of Inhaled Nanoparticles....Pages 145-171
Particles of Biomedical Relevance and Their Interactions: A Classical and Quantum Mechanistic Approach to a Theoretical Description....Pages 173-186
Health Effects of Nanoparticles (Inhalation) from Medical Point of View/Type of Diseases....Pages 187-202
Effects of Cigarette Smoke and Diesel Exhaust on the Innate Immune Function of the Airway Epithelium....Pages 203-210
The Potential Harmful and Beneficial Effects of Nanoparticles in Children....Pages 211-226
Targeting Drugs to the Lungs – The Example of Insulin....Pages 227-249
Protection of the Respiratory System Against Nanoparticles Inhalation....Pages 251-277
Overview and Discussion....Pages 279-284
Back Matter....Pages 285-287
