The rapidly developing field of nanomaterials has expanded in many commercial areas. More recent studies have begun to provide a foundation for understanding how nanomaterials influence cells and how they also can serve as methodological tools for studies in medicine and cell biology, including research into stem cells. Recent investigations have shown affects of nanomaterials on specific subcellular structures, such as the actin-based brush border network in cells with an increasing emphasis on the barrier function of epithelial tissues. While other studies have shown involvement of nanoparticles in specific cytoplasmic signal transduction events such as the rise in intracellular free calcium, a signaling event known to regulate many changes in cell architecture and function. In parallel, nanomaterials are increasingly used in medicine for drug delivery, treatment of cancer and an increasing number of new applications. This book investigates these areas and also includes new methods for assessment in cell biology and medicine.
Author(s): David G. Capco, Yongsheng Chen (eds.)
Series: Advances in Experimental Medicine and Biology 811
Edition: 1
Publisher: Springer Netherlands
Year: 2014
Language: English
Pages: 278
Tags: Biomedicine general; Medicine/Public Health, general; Cell Biology; Nanotechnology and Microengineering; Characterization and Evaluation of Materials
Front Matter....Pages i-xi
Presence in, and Release of, Nanomaterials from Consumer Products....Pages 1-17
Nanoparticle Aggregation: Principles and Modeling....Pages 19-43
Influences of Nanomaterials on the Barrier Function of Epithelial Cells....Pages 45-54
Engineered Nanoparticles Induced Brush Border Disruption in a Human Model of the Intestinal Epithelium....Pages 55-72
Nanoparticles: Cellular Uptake and Cytotoxicity....Pages 73-91
Atomic Force Microscopy Study of the Interaction of DNA and Nanoparticles....Pages 93-109
Intracellular Signal Modulation by Nanomaterials....Pages 111-134
Nanomaterials: Impact on Cells and Cell Organelles....Pages 135-156
Design, Synthesis, and Functionalization of Nanomaterials for Therapeutic Drug Delivery....Pages 157-182
Preparation of Nanoscale Pulmonary Drug Delivery Formulations by Spray Drying....Pages 183-206
Nanomedicine: The Promise and Challenges in Cancer Chemotherapy....Pages 207-233
Transgenerational Effects of NMs....Pages 235-254
Stem Cells and Nanomaterials....Pages 255-275
Back Matter....Pages 277-278
