N-Oxidation of Drugs: Biochemistry, pharmacology, toxicology

Front Matter....Pages i-xx
Front Matter....Pages 1-1
Formation of aromatic amine free radicals by prostaglandin hydroperoxidase and peroxyl radicals: analysis by ESR and stable end products....Pages 3-18
The Application of 15 N-NMR in the Analysis of N -Oxygenated amidines and guanidines....Pages 19-35
Radioimmunoassay and other methods for trace analysis of N -oxide compounds....Pages 37-55
Front Matter....Pages 57-57
Mechanism, multiple forms and substrate specificities of flavin-containing mono-oxygenases....Pages 59-70
On the genetic polymorphism of the flavin-containing mono-oxygenase....Pages 71-90
Factors regulating the activity of the rabbit lung flavin-containing mono-oxygenase....Pages 91-105
Human pharmacogenetics of nitrogen oxidations....Pages 107-131
Microbial N -hydroxylases....Pages 133-139
Roles of aminium radical intermediates in the biotransformation of dihydropyridines, cycloalkylamines, and N,N -dimethylanilines by cytochrome P -450 enzymes....Pages 141-155
The role of cytochrome P -450 in the biological nuclear N -oxidation of aminoaza-heterocyclic drugs and related compounds....Pages 157-184
New aspects of the microsomal N -hydroxylation of benzamidines....Pages 185-205
Studies on the N -oxidation of phentermine: evidence for an indirect pathway of N -oxidation mediated by cytochrome P -450....Pages 207-215
Molecular activation mechanisms involved in arylamine cytotoxicity: peroxidase products....Pages 217-236
Front Matter....Pages 237-237
Reduction and conjugation reactions of N -oxides....Pages 239-261
In vivo metabolism of N -oxides....Pages 263-286
Purification and characterization of rat hepatic acetyltransferase....Pages 287-292
Front Matter....Pages 293-293
Metabolism and activation of nitrosamines catalysed by cytochrome P -450 isoenzymes....Pages 295-311
Cytochrome P -450 catalysed activation of carcinogenic aromatic amines and amides....Pages 313-329
Comparative biochemistry of cytochrome P -450 species responsible for the activation of mutagenic food-derived heterocyclic amines....Pages 331-343
Specificity and inducibility of cytochrome P -450 catalysing the activation of food-derived mutagenic heterocyclic amines....Pages 345-355
Front Matter....Pages 293-293
Monoamine oxidase-mediated activation of MPTP and related compounds....Pages 357-369
Activation of aromatic amines by oxyhaemoglobin....Pages 371-391
Relevance of primary and secondary nitroxide radicals in biological oxidations....Pages 393-422
Molecular approaches to evaluation of the risk of aromatic amine-induced bladder cancer: smoking-related carcinogen—DNA adducts in biopsied samples of human urinary bladder....Pages 423-434
The role of N -oxidation by leukocytes in drug-induced agranulocytosis and other drug hypersensitivity reactions....Pages 435-453
Phototoxic effects of N -oxidized drugs and related compounds....Pages 455-473
Back Matter....Pages 475-487