This volume will be a collection of chapters from authors with wide experience in their research field. The purpose is to produce a coherent book that reflects the common theme of theory in medical thinking and multidisciplinary research practice. In this context "theory" relates to frameworks of concepts, facts, models etc that help to inform practitioners (clinicians, scientists and engineers) both within their own fields and as they seek to share dialogue with colleagues from other fields. The book will therefore be integrative across a broad spectrum of fields within medicine. To achieve this the chapters will be associated with others in a number of meaningful ways. Each chapter will share a number of points of contact that will include at least two of the following: *similar biomedical area (e.g., immunity, neuroscience, endocrinology, pathology, oncology, haematology, .) *similar multidisciplinary theoretical contexts (e.g., modelling, analysis, description, visualization, complex systems, .) *similar multidisciplinary medical issues and questions (e.g., clinical practice, decision making, informatics, .) ?·Uniquely explores role of interdisciplinary exchange in the development and expansion of medical theory?·Timely and insightful essays on the growth and development of medical theories from some of the world's top clinicians and medical researchers, including Werner Arber, Frank Vertosick, and David Weatherall?·Assembles diverse perspectives on medicine and physiology from biology, statistics, ethics, computer science, philosophy, history?·Uniquely illuminates the social and historical processes through which theoretical research translates into clinical practice?·Reveals the growing role of technology, especially computational modelling, in changing the nature of Western medicine
Author(s): Ray Paton and Laura A. McNamara (Eds.)
Series: Studies in Multidisciplinarity 3
Edition: 1
Publisher: Elsevier, Academic Press
Year: 2005
Language: English
Pages: 1-531
Content:
Series dedication
Page v
William Shakespeare, Hamlet
Foreword
Pages vii-x
Gordon Shepherd
Contributors
Pages xi-xiv
Biographies
Pages xv-xxx
1 Disorders of haemoglobin: from phenotype to genotype Original Research Article
Pages 1-13
David J. Weatherall
2 Between bleeding and thrombosis or beyond Original Research Article
Pages 15-30
Cheng Hock Toh
3 The theory of molecular evolution and its medical implications Original Research Article
Pages 31-45
Werner Arber
4 What is a medical theory? Original Research Article
Pages 47-62
Paul Thagard
5 Medicine as a moral epistemology Original Research Article
Pages 63-88
Alfred I. Tauber
6 Theory in medical education — an oxymoron? Original Research Article
Pages 89-102
Sam Leinster
7 Knowledge, arguments, and intentions in clinical decision-making Original Research Article
Pages 103-129
John Fox, David Glasspool
8 Analogies, conventions, and expert systems in medicine: some insights from a XIX century physiologist Original Research Article
Pages 131-145
Guido Fioretti
9 Reliability of measurements in medical research and clinical practice Original Research Article
Pages 147-163
David Y. Downham, Anna Maria Holmbäck, Jan Lexell
10 Advanced data mining and predictive modelling at the core of personalised medicine Original Research Article
Pages 165-192
Roland Somogyi, John P. McMichael, Sergio E. Baranzini, Parvin Mousavi, Larry D. Greller
11 Designs and therapies for stochastic neural systems Original Research Article
Pages 193-207
Andre Longtin
12 Mining scenarios for hepatitis B and C Original Research Article
Pages 209-229
Yukio Ohsawa, Naoaki Okazaki, Naohiro Matsumura, Akio Saiura, Hajime Fujie
13 Modelling the in vivo growth rate of HIV: implications for vaccination Original Research Article
Pages 231-246
Ruy M. Ribeiro, Narendra M. Dixit, Alan S. Perelson
14 A flexible, iterative approach to physiological modelling Original Research Article
Pages 247-264
Murad Banaji, Stephen Baigent
15 Systems biology, cell specificity, and physiology Original Research Article
Pages 265-279
Vincent Detours, Jacques E. Dumont, Carine Maenhaut
16 Modelling T cell activation, proliferation, and homeostasis Original Research Article
Pages 281-308
Andrew J. Yates, Cliburn C.T. Chan, Robin E. Callard
17 A theory for complex systems: reactive animation Original Research Article
Pages 309-324
Sol Efroni, David Harel, Irun r. Cohen
18 Modelling of haemodynamics in the cardiovascular system by integrating medical imaging techniques and computer modelling tools Original Research Article
Pages 325-351
Nigel Bruce Wood, Xiao Yun Xu
19 Vasopressin and homeostasis — running hard to stay in the same place Original Research Article
Pages 353-368
Nancy Sabatier, Gareth Leng
20 Mathematical modelling of angiogenesis and vascular adaptation Original Research Article
Pages 369-387
Tomas Alarcon, Helen Byrne, Philip Maini, Jasmina Panovska
21 Towards understanding the physical basis of re-entrant cardiac arrhythmias Original Research Article
Pages 389-410
Oleg V. Aslanidi, Vadim N. Biktashev, Irina V. Biktasheva, Richard H. Clayton, Arun V. Holden
22 Reflections on the quantitative analysis of liver fibrosis in biopsy specimens Original Research Article
Pages 411-429
Nicola Dioguardi
23 A network approach to living tissues Original Research Article
Pages 431-445
Frank T. Vertosick Jr.
24 Genetic algorithms in radiotherapy Original Research Article
Pages 447-482
Olivier C.L. Haas, Colin R. Reeves
25 Tissue engineering: the multidisciplinary epitome of hope and despair Original Research Article
Pages 483-524
David F. Williams
Index
Pages 525-531
