mTOR Pathway and mTOR Inhibitors in Cancer Therapy provides an up-to-date survey of the rapidly advancing field of cancer therapy. Our understanding of the mechanisms involved in cancer genesis and progression underwent unprecedented expansion during the last decade, opening a new era of cancer treatment – targeted therapy. The surge in this area results in no small part from studies conducted jointly by basic health scientists and clinical investigators. It is our hope that this book will help foster even further collaboration between investigators in these two disciplines. In this work, experts in TOR signaling have contributed in two thematic areas: mTOR Signaling and Cancer Therapy (chapters 1 - 8) and Therapeutic Targeting Downstream of mTOR (chapter 9 – 13). All chapters of mTOR Pathway and mTOR Inhibitors in Cancer Therapy are completely new or have been extensively updated by their authors; and we are indebted to all authors who have exemplified the links between these 2 thematic areas.
Author(s): Neil Kubica, John Blenis (auth.), Vitaly A. Polunovsky, Peter J. Houghton (eds.)
Series: Cancer Drug Discovery and Development
Edition: 1
Publisher: Humana Press
Year: 2010
Language: English
Pages: 304
Tags: Cancer Research; Cell Biology; Pharmacology/Toxicology
Front Matter....Pages i-xii
mTORC1: A Signaling Integration Node Involved in Cell Growth....Pages 1-36
The Regulation of the IGF-1/mTOR Pathway by the p53 Tumor Suppressor Gene Functions....Pages 37-48
mTOR Signaling in Angiogenesis....Pages 49-74
mTORC1 Signaling and Hypoxia....Pages 75-97
mTOR Signaling in Glioblastoma: Lessons Learned from Bench to Bedside....Pages 99-111
mTOR and Cancer Therapy: General Principles....Pages 113-131
mTOR and Cancer Therapy: Clinical Development and Novel Prospects....Pages 133-148
Drug Combinations as a Therapeutic Approach for mTORC1 Inhibitors in Human Cancer....Pages 149-178
Downstream Targets of mTORC1....Pages 179-200
Downstream of mTOR: Translational Control of Cancer....Pages 201-216
Genome-Wide Analysis of Translational Control....Pages 217-236
Translational Control of Cancer: Implications for Targeted Therapy....Pages 237-255
Downstream from mTOR: Therapeutic Approaches to Targeting the eIF4F Translation Initiation Complex....Pages 257-285
Back Matter....Pages 287-301
