Within the complex neuronal network of the nervous system, neuron-to-neuron communication occurs mainly through chemical synapses, where the presynaptic nerve terminal releases neurotransmitters that control the function of postsynaptic neurons by acting on postsynaptic receptors. Recent decades have brought groundbreaking new developments and a wealth of knowledge to this field. In Molecular Mechanisms of Neurotransmitter Release, leading experts provide concise, up-to-date information on all major molecular mechanisms involved, with complete background information and figures and diagrams to further elucidate key concepts or experiments.
Comprehensive and cutting-edge, Molecular Mechanisms of Neurotransmitter Release is sure to provide a learning tool for neuroscience students, a solid reference for neuroscientists, and a source of knowledge for all those who have a general interest in the ever-evolving field of neuroscience.
Author(s): R. Grace Zhai (auth.), Zhao-Wen Wang (eds.)
Series: Contemporary Neuroscience
Edition: 1
Publisher: Humana Press
Year: 2008
Language: English
Pages: 347
Tags: Neurosciences; Cell Biology; Neurobiology; Neurology; Human Physiology
Front Matter....Pages i-xiii
The Architecture of the Presynaptic Release Site....Pages 1-16
Multiple Modes of Fusion and Retrieval at the Calyx of Held Synapse....Pages 17-34
Roles of SNARE Proteins in Synaptic Vesicle Fusion....Pages 35-59
Roles and Sources of Calcium in Synaptic Exocytosis....Pages 61-84
Regulation of Presynaptic Calcium Channels....Pages 85-106
Synaptotagmin: Transducing Ca 2+ -Binding to Vesicle Fusion....Pages 107-134
Functional Interactions Among the SNARE Regulators UNC-13, Tomosyn, and UNC-18....Pages 135-156
Roles of the ELKS/CAST Family and SAD Kinase in Neurotransmitter Release....Pages 157-170
The Role of Potassium Channels in the Regulation of Neurotransmitter Release....Pages 171-185
Modulation of Neurotransmitter Release and Presynaptic Plasticity by Protein Phosphorylation....Pages 187-206
Synaptic Vesicle Endocytosis....Pages 207-238
Lipids and Secretory Vesicle Exocytosis....Pages 239-261
Neurotransmitter Reuptake and Synaptic Vesicle Refilling....Pages 263-295
Regulation of Neurotransmitter Release by Presynaptic Receptors....Pages 297-314
Transsynaptic Regulation of Presynaptic Release Machinery in Central Synapses by Cell Adhesion Molecules....Pages 315-326
Differential Regulation of Small Clear Vesicles and Large Dense-Core Vesicles....Pages 327-339
Back Matter....Pages 341-347
