Childhood brain tumors are a diverse group of diseases characterized by the abnormal growth of tissue contained within the skull. Other than leukemia and lymphoma, brain tumors are the most common type of neoplasms that occur in children. The leading cause of death from childhood neoplasms among persons up to 19 years is brain tumors. As such, this book is a review of the most recent molecular biological research concerning brain tumors with references and comparisons to a variety of neoplastic disorders. The book then uses this information to foreshadow the direction that future anti-neoplastic therapies will take. Because of the wide spectrum of the objectives of the book, any individual involved in cancer research will greatly benefit from the work. Histopathologists, neuropathologists, clinical and research oncologists, and medical students will find this book to be an invaluable resource as a reference guide. Patients and their families will also find the book useful as it offers a comprehensive update on new, non-classical therapeutic modality options and contains a detailed description and analysis of brain tumors. Such an endeavor has yet to be undertaken by any other book and may prove to be the most comprehensive book on brain tumors thus far.
Author(s): Bela Bodey, Stuart E. Siegel, Hans E. Kaiser
Edition: 1
Publisher: Springer
Year: 2004
Language: English
Pages: 381
Tags: Медицинские дисциплины;Онкология;
Table of Contents......Page 6
Contributors......Page 10
Acknowledgements......Page 12
Preface......Page 14
Growth Factors in Mammalian Embryogenesis and Neoplastic Transformation......Page 16
I. MOLECULAR BIOLOGY OF TUMORS......Page 20
2. Medulloblastoma......Page 22
3. Glial Tumors......Page 26
1. Introduction......Page 32
2. The Significance of Immunohistochemistry......Page 39
3. Original Immunohistochemical Observations......Page 52
4. Intermediate filaments (IFs)......Page 56
5. Expression of Homeobox B3, B4, and C6 Gene Products......Page 65
6. Cell proliferation......Page 77
7. Epidermal growth factor (EGF) and its receptor (EGFR)......Page 85
8. p53, the guardian of the integrity of the genome......Page 90
9. Apoptosis in Brain Tumors......Page 96
10. Survivin......Page 116
11. Tumor-related Neoangiogenesis in Childhood Brain Tumors......Page 119
12. Presence of Matrix Metalloproteinases (MMPs)......Page 127
13. The MAGE gene family......Page 135
II. ANTI-NEOPLASTIC BIOLOGICAL THERAPIES......Page 182
3. Experimental Therapies in Brain Tumors......Page 188
1. Introduction......Page 192
2. Active nonspecific immunomodulation of natural immunity......Page 196
3. Thymic hormones......Page 199
4. Interferons: basic and preclinical studies......Page 205
5. Tumor Necrosis Factors......Page 212
6. The discovery of interleukin-2: basic principles......Page 222
5. The lymphokine activated killer (LAK) cell phenomenon......Page 246
1. Administration of rIL-2 and LAK cells: preclinical trials......Page 248
6. Angiogenesis Inhibition in Anti-Neoplastic Therapy......Page 252
1. Active antigen specific immunotherapy (tumor vaccines)......Page 258
3. Immunosuppression within the Cellular Microenvironment of Childhood Brain Tumors......Page 264
4. The Dendritic Cell Network......Page 265
5. Antigen Presentation by DCs......Page 273
6. The Significance of DCs in Anti-Neoplastic Immunotherapy......Page 277
1. Introduction......Page 304
3. Oncogenes and Growth Factors in Neoplastic Cells......Page 305
4. Antibodies and Neoplastic Cells......Page 306
5. Anti-neoplastic Immunotherapeutical Regiments Influenced by Immunohistochemistry......Page 309
6. Human Antibodies......Page 311
7. Anti-Idiotypic Antibodies......Page 312
8. Bispecific Antibodies......Page 313
9. Radiolabeled Antibodies......Page 315
10. Construction of Immunotoxins......Page 317
11. Monoclonal Antibodies: Carriers of Drugs, Toxins and Cytotoxic Cells......Page 318
12. Clinical Trials with Monoclonal Antibodies and their Minimal Toxicity......Page 320
1. Introduction......Page 336
2. Cancer/Testis Antigens......Page 337
3. Detection of Cancer/Testis Antigens in Various Malignant Neoplasms and their Therapeutic Significance......Page 340
Prologue......Page 352
III. APPENDIX......Page 358
1. Tissues and Tissue Handling......Page 360
2. Libraries of Antibodies......Page 363
4. Immunoalkaline Phosphatase Antigen Detection Technique......Page 366
5. Immunoperoxidase Antigen Detection Technique......Page 367
7. Evaluation of the Immunoreactivity (immunostaining)......Page 368
10. Isolation of Cortical Thymocytes......Page 369
11. Isolation of Thymic Nurse Cells (TNCs)......Page 370
12. Thymic Stromal Cell (RE & DC) Cultures......Page 371
14. Transmission Electronmicroscopy (TEM) of Cultured Thymic Medullary Cells (RE, DC, including LC, & IDC) and Macrophages......Page 372
15. Scanning Electronmicroscopic (SEM) Procedure for Tissue Samples......Page 373
C......Page 376
E......Page 377
I......Page 378
N......Page 379
S......Page 380
W......Page 381
