Pancreatic cancer is a formidable disease, and advances in early detection and improved therapeutics have been slow to come forth. With new advances in molecular genetics in the field of pancreatic tumorigenesis, it is an opportune time to use these recent discoveries to enhance our understanding of pancreatic cancer biology and to improve outcomes in patients.
In this volume, leading experts in the field shed light on these findings describing the mutational landscape of pancreatic cancer, including new inroads into our understanding of familial pancreatic cancer, epidemiology, the biology of K-ras signaling, and the emerging contribution of epigenetic alterations to disease initiation and progression. The distinctive pancreatic cancer-stroma ecosystem as determined by the dynamic interplay of inflammation, hallmark mutations, EMT, and cancer stem cells is described, and implications of these interactions in the context of development of novel, personalized therapeutic options are explored.
Author(s): Marco Dal Molin M.D., Anirban Maitra M.B.B.S. (auth.), Diane M. Simeone, Anirban Maitra (eds.)
Edition: 1
Publisher: Springer-Verlag New York
Year: 2013
Language: English
Pages: 235
Tags: Cancer Research; Cell Biology; Human Genetics
Front Matter....Pages i-v
Genomic Alterations in Sporadic Pancreatic Cancer....Pages 1-26
Molecular Pathology of Pancreatic Cancer Precursor Lesions....Pages 27-47
Genetic Epidemiology and Pancreatic Cancer....Pages 49-74
Translational Implications of Molecular Genetics for Early Diagnosis of Pancreatic Cancer....Pages 75-82
The Biology of K-Ras Signaling Pathways in Pancreatic Cancer....Pages 83-115
Molecular Targeted Therapies in Pancreatic Cancer....Pages 117-144
Mouse Models of Pancreatic Ductal Adenocarcinoma....Pages 145-170
The Genetics of Pancreatic Cancer Progression....Pages 171-184
Epigenetic Alterations in Pancreatic Cancer....Pages 185-207
Innovative Technologies in the Molecular Characterization of Pancreatic Cancer....Pages 209-228
Back Matter....Pages 229-235
