Cancer is a genetic disease and cancer research is a broad discipline embracing investigators and clinicians with diverse backgrounds. This new edition of Molecular Genetics of Liver Neoplasia intends to provide a comprehensive view on genetics and a mechanistic understanding of liver cancer. The book covers from molecular pathogenesis and cellular origin to translational genomics of liver cancer. The leading experts in the field of liver cancer have thoroughly summarized the latest developments and have provided current viewpoints and novel concepts. This cutting-edge volume is a vital resource for today’s basic cancer researchers, graduate students, medical students and clinicians interested in hepatocarcinogenesis.
Author(s): Xin Wei Wang, Joe W. Grisham M.D., Snorri S. Thorgeirsson M.D., Ph.D. (auth.), Xin Wei Wang, Joe W. Grisham, Snorri S. Thorgeirsson (eds.)
Series: Cancer Genetics
Edition: 1
Publisher: Springer-Verlag New York
Year: 2011
Language: English
Pages: 399
Tags: Cancer Research; Pharmacology/Toxicology
Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Biology of Hepatocellular Carcinoma: Past, Present and Beyond....Pages 3-17
Overview of Cholangiocarcinoma and Evidence for a Primary Liver Carcinoma Spectrum....Pages 19-33
Front Matter....Pages 35-35
Pathology of Hepatocellular Carcinoma....Pages 37-48
Front Matter....Pages 49-49
Epidemiology of Hepatocellular Carcinoma....Pages 51-73
Genetics and Epidemiology of Cholangiocarcinoma....Pages 75-99
Front Matter....Pages 101-101
Signaling Pathways in Viral Related Pre-neoplastic Liver Disease and Hepatocellular Carcinoma....Pages 103-127
Epigenetic Effects of Persistent Hepatitis C Virus Infection and Hepatocellular Carcinoma....Pages 129-145
DNA Methylation Status in Chronic Liver Disease and Hepatocellular Carcinoma....Pages 147-159
Front Matter....Pages 161-161
Transgenic and Knockout Mouse Models of Liver Cancer....Pages 163-188
Mosaic Cancer Mouse Models and Functional Oncogenomics in Hepatocellular Carcinoma....Pages 189-196
The Zebrafish Model for Liver Carcinogenesis....Pages 197-218
Front Matter....Pages 219-219
Integrative and Functional Genomics of HCC....Pages 221-240
Molecular Signatures of Hepatocellular Carcinoma Metastasis....Pages 241-257
Gene Mutations and Transcriptomic Profiles Associated to Specific Subtypes of Hepatocellular Tumors....Pages 259-275
Front Matter....Pages 277-277
Cancer Stem Cells and Liver Cancer....Pages 279-299
Heterogeneity of Liver Cancer Stem Cells....Pages 301-317
Cancer Stem Cells in Liver Carcinoma....Pages 319-333
Front Matter....Pages 335-335
Molecular Signaling in Hepatocellular Carcinoma....Pages 337-348
Molecular Events on Metastasis of Hepatocellular Carcinoma....Pages 349-371
Molecular Pathogenesis of Hepatocellular Carcinoma....Pages 373-396
Back Matter....Pages 397-399
