Molecular Diagnostics in Dermatology and Dermatopathology presents the basics of molecular biology and molecular diagnostic methods most commonly used in the clinical laboratory, with an emphasis on the concepts and testing most relevant to dermatological diseases. Topics include the integration of newer diagnostic and prognostic techniques with ‘traditional’ histologic approaches, and discussions of regulatory, ethical, legal, economic issues and ‘newer’ technologies. This important diagnostic tool outlines the clinically relevant uses (i.e.; diagnostic, staging and/or prognostic) applications of these techniques in the field of dermatology. Molecular studies that investigate the pathogenesis of skin diseases will be excluded, unless they also have a direct diagnostic utility. The book will be of interest to practicing pathologists, dermatology and pathology residents, dermatologists, and dermatopathologists.
Author(s): Michael J. Murphy (auth.), Michael J. Murphy (eds.)
Series: Current Clinical Pathology
Edition: 1
Publisher: Humana Press
Year: 2011
Language: English
Pages: 478
Tags: Pathology; Dermatology; Molecular Medicine
Front Matter....Pages i-xiii
Introduction to Molecular Diagnostic Testing in Dermatology and Dermatopathology....Pages 1-12
Principles of Molecular Biology....Pages 13-25
Technologies in the Molecular Diagnostics Laboratory....Pages 27-55
Cytogenetics of Primary Skin Tumors....Pages 57-72
Melanocytic Neoplasms I: Molecular Diagnosis....Pages 73-103
Melanocytic Neoplasms II: Molecular Staging....Pages 105-130
Non-Melanoma Skin Cancers and Hereditary Cancer Syndromes....Pages 131-143
Cutaneous Sarcomas and Soft Tissue Proliferations....Pages 145-189
Molecular Determination of Tissue Margins, Clonal Origin, and Histogenesis of Skin Cancers....Pages 191-202
Mycosis Fungoides and Related Lesions....Pages 203-231
Cutaneous Non-MF T-Cell and NK-Cell Lymphoproliferative Disorders....Pages 233-245
Cutaneous B-Cell Lymphomas....Pages 247-262
Leukemia Cutis....Pages 263-281
Inflammatory Disorders of the Skin....Pages 283-310
Infectious Diseases of the Skin I: Dermatophytosis/Onychomycosis....Pages 311-337
Infectious Diseases of the Skin II: Non-Dermatophytic Infections....Pages 339-357
Wound Healing Disorders: Chronic Wounds and Keloids....Pages 359-368
Alopecias....Pages 369-378
Genodermatoses: Inherited Diseases of the Skin....Pages 379-409
Molecular Aspects of Skin Aging....Pages 411-418
Pharmacogenetics and Pharmacogenomics I: Linking Diagnostic Classification to Therapeutic Decisions....Pages 419-441
Pharmacogenetics and Pharmacogenomics II: Genetic Determinants of Drug Responses and Adverse Drug Reactions....Pages 443-452
Regulatory, Legal, Coding, Billing, Reimbursement, and Ethical Considerations for Molecular Diagnostic Testing in Dermatology and Dermatopathology....Pages 453-464
Back Matter....Pages 465-478
