Molecular Toxicology is the first volume of a three-volume set Molecular, Clinical and Environmental Toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals in daily life. By providing intriguing insights far down to the molecular level, this work covers the entire range of modern toxicology with special emphasis on recent developments and achievements. It is written for students and professionals in medicine, science, public health and engineering who are demanding reliable information on toxic or potentially harmful agents and their adverse effects on the human body.
Author(s): Antoinette N. Hayes, Steven G. Gilbert (auth.), Andreas Luch (eds.)
Series: Experientia Supplementum 99
Edition: 1
Publisher: Birkhäuser Basel
Year: 2009
Language: English
Pages: 470
City: Boston
Tags: Pharmacology/Toxicology
Front Matter....Pages I-XIV
Historical milestones and discoveries that shaped the toxicology sciences....Pages 1-35
Physiologically based toxicokinetic models and their application in human exposure and internal dose assessment....Pages 37-55
The role of biotransformation and bioactivation in toxicity....Pages 57-86
Genotoxicity: damage to DNA and its consequences....Pages 87-110
Role of DNA repair in the protection against genotoxic stress....Pages 111-150
On the impact of the molecule structure in chemical carcinogenesis....Pages 151-179
Chemical induced alterations in p53 signaling....Pages 181-208
Molecular pathways involved in cell death after chemically induced DNA damage....Pages 209-230
The aryl hydrocarbon receptor at the crossroads of multiple signaling pathways....Pages 231-257
Mapping the epigenome — impact for toxicology....Pages 259-288
Receptors mediating toxicity and their involvement in endocrine disruption....Pages 289-323
Toxicogenomics: transcription profiling for toxicology assessment....Pages 325-366
The role of toxicoproteomics in assessing organ specific toxicity....Pages 367-400
High-throughput screening for analysis of in vitro toxicity....Pages 401-452
Back Matter....Pages 453-470
