This companion to Brenner and Rector's The Kidney offers a state-of-the-art summary of the most recent advances in renal genetics. Molecular and Genetic Basis for Renal Disease provides the nephrologist with a comprehensive look at modern investigative tools in nephrology research today, and reviews the molecular pathophysiology of the nephron as well as the most common genetic and acquired renal diseases. A comprehensive clinical review of Medelian renal disease is also be included.Detailed review of the molecular anatomy and pathophysiology of the nephron that provides relevant basic science to consider when diagnosing and managing patients with these disorders.
Author(s): David B. Mount MD, Martin R. Pollak MD
Edition: 1
Publisher: Saunders
Year: 2007
Language: English
Pages: 592
Tags: Медицинские дисциплины;Нефрология;
Cover......Page 1
Contributors......Page 4
1. The Impact of Molecular Genetics on Nephrology......Page 8
2. Manipulation of the Mouse Genome: Studying Renal Function and Disease......Page 10
3. Cardiorenal Physiology of the Mouse: From Loss of Genome to Gain of Phenome......Page 21
4. Murine Models of Kidney Development......Page 46
5. Hereditary Disorders of Renal and Urogenital Development......Page 54
6. Autosomal Dominant Polycystic Kidney Disease......Page 89
7. Autosomal Recessive Polycystic Kidney Disease......Page 122
8. Pathogenesis of Nephronophthisis and Medullary Cystic Kidney Disease......Page 134
9. Inherited Nephroses......Page 144
10. Molecular and Genetic Basis of Alport Syndrome......Page 154
11. Nail-Patella Syndrome......Page 175
12. The Primary Hyperoxalurias: Molecular and Clinical Insights......Page 181
13. Fabry Disease......Page 196
14. Hereditary Disorders of the Proximal Tubule......Page 201
15. Hereditary Disorders of the Thick Ascending Limb and Distal Convoluted Tubule......Page 228
16. Hereditary Disorders of Collecting Duct Sodium and Potassium Transport......Page 249
17. Hereditary Renal Tubular Acidosis......Page 267
18. Hereditary Causes of Nephrogenic Diabetes Insipidus......Page 293
19. Genetic Disorders of Calcium and Phosphate Homeostasis......Page 309
20. Genetics and Renal Pathophysiology of Essential Hypertension......Page 344
21. Molecular Mechanisms of Proteinuria......Page 370
22. Diabetic Nephropathy......Page 387
23. Pathogenesis of HIV-Associated Nephropathy......Page 414
24. Pathogenesis of Paraproteinemic Renal Disease......Page 430
25. Preeclampsia......Page 436
26. Molecular Insights into the Thrombotic Microangiopathies......Page 447
27. The Molecular Basis of IgA Nephropathy......Page 479
28. Glomerulonephritis Caused by Antineutrophil Cytoplasmic Autoantibodies......Page 496
29. Systemic Lupus Erythematosus and the Kidney......Page 507
30. Molecular and Genetic Aspects of Ischemic Acute Kidney Injury......Page 529
Index......Page 554
