This book presents the major therapeutic applications of modified rice bran arabinoxylan compound (RBAC) in cancer as well as other chronic inflammatory diseases. Written by active researchers and clinicians in the field of RBAC, the chapters cover the basic science that defines the unique function of RBAC as well as the clinical evidence derived through human studies. Particular focus is on recent findings from research over the past decades. This book is both practical and evidence based. It will be a core resource for researchers, students, and practitioners of nutrition and natural medicine, as well as be of value to all healthcare professionals with interest in integrative medicine.
Author(s): Sok Cheon Pak, Soo Liang Ooi, Peter S. Micalos, Mamdooh H. Ghoneum
Publisher: Springer
Year: 2023
Language: English
Pages: 156
City: Singapore
Foreword
Preface
Acknowledgments
Contents
Editors and Contributors
Abbreviations
List of Figures
List of Table
Part I: Introduction
1: Introduction to Rice Bran Arabinoxylan Compound
1.1 Rice
1.2 Rice Bran
1.3 Rice Bran Dietary Fiber
1.4 Rice Bran Arabinoxylans
1.5 Rice Bran Arabinoxylan Compound/MGN-3/Biobran
1.6 Conclusion
References
Part II: Therapeutic Properties
2: Enhancing Natural Killer Cell Activity
2.1 Introduction
2.2 Superiority of Biobran/MGN-3 in Comparison with Other BRMs
2.3 Biobran/MGN-3 Reverses Aging- and Cancer-Induced NK Cell Suppression
2.3.1 Aging
2.3.2 Cancer
2.3.3 Effective Concentration and Biosafety
2.4 Conclusion
References
3: Immunomodulatory, Antioxidant, Antiangiogenic, and Antiproliferative Effects of Rice Bran Arabinoxylan
3.1 Introduction
3.2 Immunomodulation
3.2.1 Phagocytic Cellular Functions
3.2.2 Dendritic Cell Maturation
3.2.3 Cytokine Modulation
3.2.4 T and B Cell Proliferation
3.3 Antioxidation
3.4 Anti-angiogenesis
3.5 Antiproliferation
3.6 Conclusion
References
4: Anti-inflammatory Agent
References
Part III: Applications in Cancer
5: Integrative Oncology
5.1 Definition of Integrative Oncology
5.2 The Principle of Integration in Cancer Patient Management
5.3 Role of Conventional Modalities in Cancer Management
5.4 Role of Complementary Modalities in Cancer Management
5.4.1 Mind and Body Practices
5.4.2 Natural Products
5.4.2.1 Dietary Supplements
5.4.2.2 Herbal Medicine
5.4.2.3 Nutraceutical Medicine, Natural Product Drugs, and Botanical Drugs
5.5 Lifestyle Modification as a Complementary Modality
5.5.1 Nutritional Oncology
5.5.2 Physical Activity
5.6 Evidence-Based Integration
References
6: The Therapeutic Application of RBAC in Cancer
6.1 Immunological Background
6.1.1 Tumor-Induced Immune Dysregulation
6.1.2 Modulation of Innate Immune Mechanisms by RBAC
6.1.3 The Central Role of NKG2D as the Ligand for NK Cells
6.2 Case Reports Which Support the Clinical Benefits of RBAC
6.2.1 A Patient with Lung Adenocarcinoma Treated with Erlotinib and RBAC
6.2.2 A Patient with Carcinoma in the Biliary Duct Treated with Another GFR Signaling Pathway (MEK/BRAF) Inhibitor and RBAC
6.2.3 Effect of Cytostatic Therapy on the Stress-Related NKG2D Ligands on Tumor Cells
6.3 Conclusion
References
7: Radiation Therapy
7.1 Introduction
7.2 Biological Effects of Rice Bran Arabinoxylan and Radiation Therapy
7.3 Animal Studies on Rice Bran Arabinoxylan and Radiation Therapy
7.4 Clinical Studies on Rice Bran Arabinoxylan and Radiation Therapy
7.5 Future Directions
References
8: Health-Related Quality of Life
8.1 Quality of Life of Cancer Patients
8.2 Disease Mechanisms Affecting QoL
8.2.1 Systemic Inflammation
8.2.2 Behaviour Comorbidities
8.2.3 Nutritional Status
8.2.4 Targeting Inflammation to Improve QoL
8.3 RBAC for QoL of Cancer Patients
8.3.1 Direct and Indirect Pathways
8.3.2 Current Evidence
8.4 Future Directions
References
Part IV: Applications in Other Conditions
9: Chronic Microinflammation as ``Friendly-Fire´´ in Aging and Disease
9.1 Introduction
9.2 Trace Experiments of BioBran In Vivo
9.3 Oxidants Attack as Friendly-Fire Causing Inflammation in Lifestyle-Related Disease and Aging
9.4 Tobacco and Cigarettes as a Model of the Initiator and Promoter of Carcinogenesis
9.5 Cancer in the Upper Digestive Tract
9.6 Human Papillomavirus and Cervical Cancer
9.7 Hepatocellular Carcinoma
9.8 Atherosclerosis and Arteriosclerosis
9.9 Alzheimer´s Disease
9.10 Summary
References
10: Human Immunodeficiency Virus (HIV)
10.1 Introduction
10.2 From Infection to CD4+ T Cell Destruction
10.3 The Potential Benefits of Biobran Against HIV
10.3.1 In Vitro Anti-HIV Effects
10.3.2 Lymphocyte Proliferation
10.3.3 CD4+ T Cell Count and CD4/CD8 Ratio
10.3.4 Systolic Blood Pressure and Endothelial Function
10.4 Conclusion
References
11: Hepatitis
11.1 Hepatitis
11.2 D-GalN Hepatitis (Animal Model) and Arabinoxylan Rice Bran (Biobran)
11.3 Acetaminophen-Induced Hepatitis
11.4 Mechanisms of Action
11.5 Effect of Biobran on Hepatitis C Virus Patients
11.6 Effect of Biobran on Nonalcoholic Fatty Liver Disease Patients
11.7 Conclusion
References
12: Additional Potential Therapeutic Applications for Rice Bran Arabinoxylan Compound
12.1 Introduction
12.2 Fatty Liver Disease
12.3 Chronic Fatigue Syndrome
12.4 Common Cold
12.5 Diabetes
12.6 Irritable Bowel Syndrome
12.7 Rheumatoid Arthritis
12.8 Conclusion
References
Index
