Edited by one of the main driving forces behind the field's momentous rise in recent years, this one-stop reference is the first comprehensive resource to integrate recent advances.
The first part addresses biochemical aspects and applications, the second and third parts are devoted to compounds with therapeutic potential, with the third part focusing on newly introduced anticancer nucleoside drugs.
Essential reading for every scientist working in this area.
Language: English
Pages: 684
Content:
Chapter 1 Investigations on Fluorine?Labeled Ribonucleic Acids by 19F NMR Spectroscopy (pages 1–27): Christoph Kreutz and Ronald Micura
Chapter 2 8?Oxo?7,8?Dihydro?2??Deoxyguanosine: A Major DNA Oxidation Product (pages 29–47): Jean Cadet and Paolo Di Mascio
Chapter 3 Modified DNA Bases: Probing Base?Pair Recognition by Polymerases (pages 49–74): Eric T. Kool
Chapter 4 2??Deoxyribose?Modified Nucleoside Triphosphates and their Recognition by DNA Polymerases (pages 75–95): Karl?Heinz Jung and Andreas Marx
Chapter 5 Pyrimidine Dimers: UV?Induced DNA Damage (pages 97–131): Shigenori Iwai
Chapter 6 Locked Nucleic Acids: Properties, Applications, and Perspectives (pages 133–152): Poul Nielsen and Jesper Wengel
Chapter 7 Synthesis and Properties of Oligonucleotides Incorporating Modified Nucleobases Capable of Watson–Crick?Type Base?Pair Formation (pages 153–171): Mitsuo Sekine, Akio Ohkubo, Itaru Okamoto and Kohji Seio
Chapter 8 The Properties of 4??Thionucleosides (pages 173–221): Masataka Yokoyama
Chapter 9 S?Adenosyl?L?Methionine and Related Compounds (pages 223–247): Christian Dalhoff and Elmar Weinhold
Chapter 10 5?Substituted Nucleosides in Biochemistry and Biotechnology (pages 249–276): Mohammad Ahmadian and Donald E. Bergstrom
Chapter 11 Universal Base Analogues and their Applications to Biotechnology (pages 277–303): Kathleen Too and David Loakes
Chapter 12 The Properties of Locked Methanocarba Nucleosides in Biochemistry, Biotechnology, and Medicinal Chemistry (pages 305–341): Victor E. Marquez
Chapter 13 Synthesis, Chemical Properties and Biological Activities of Cyclic Bis(3?–5?)diguanylic Acid (c?di?GMP) and its Analogues (pages 343–363): Mamoru Hyodo and Yoshihiro Hayakawa
Chapter 14 Siderophore Biosynthesis Inhibitors (pages 365–391): Courtney C. Aldrich and Ravindranadh V. Somu
Chapter 15 Synthesis and Biological Activity of Selected Carbocyclic Nucleosides (pages 393–424): Adam Mieczkowski and Luigi A. Agrofoglio
Chapter 16 4??C?Ethynyl?2??Deoxynucleosides (pages 425–431): Hiroshi Ohrui
Chapter 17 Modified Nucleosides as Selective Modulators of Adenosine Receptors for Therapeutic Use (pages 433–449): Kenneth A. Jacobson, Bhalchandra V. Joshi, Ben Wang, Athena Klutz, Yoonkyung Kim, Andrei A. Ivanov, Artem Melman and Zhan?Guo Gao
Chapter 18 The Design of Forodesine HCl and Other Purine Nucleoside Phosphorylase Inhibitors (pages 451–472): Philip E. Morris and Vivekanand P. Kamath
Chapter 19 Formycins and their Analogues: Purine Nucleoside Phosphorylase Inhibitors and their Potential Application in Immunosuppression and Cancer (pages 473–510): Agnieszka Bzowska
Chapter 20 1?(3?C?Ethynyl???D?ribo?pentofuranosyl)cytosine (ECyd) (pages 511–523): Akira Matsuda
Chapter 21 Syntheses and Biological Activity of Neplanocin and Analogues (pages 525–566): Dilip K. Tosh, Hea Ok Kim, Shantanu Pal, Jeong A. Lee and Lak Shin Jeong
Chapter 22 Clitocine and Its Analogues (pages 567–584): Hyunik Shin and Changhee Min
Chapter 23 Capecitabine Preclinical Studies: From Discovery to Translational Research (pages 585–600): Hideo Ishitsuka and Nobuo Shimma
Chapter 24 Tenofovir and Adefovir as Antiviral Agents (pages 601–630): Tomas Cihlar, William E. Delaney and Richard Mackman
Chapter 25 Clofarabine: From Design to Approval (pages 631–646): John A. Secrist, Jaideep V. Thottassery and William B. Parker
