The pivotal role of mitochondrial functions in carcinogenesis is quite well established. However, the critical role of mitochondrial genome alterations to cancer development is muted in traditional textbooks. Recent scientific efforts have provided unequivocal evidence for mitochondrial genome mutations and content changes in cancer development, progression, and therapy. This pioneering book is a unique compilation of mitochondrial genome alterations in cancer. While primarily focused on the emerging role of mitochondrial genome changes, bioenergetics and signaling pathways, attention is also given to the metabolic transformations of the cancer cell, as well as the established altered cell death processes that underlie cancer evolution and treatment resistance.
Author(s): Gabriel D. Dakubo (auth.)
Edition: 1
Publisher: Springer-Verlag Berlin Heidelberg
Year: 2010
Language: English
Pages: 356
Tags: Human Genetics; Molecular Medicine; Cancer Research
Front Matter....Pages i-xv
Front Matter....Pages 1-1
Basic Mitochondrial Genetics, Bioenergetics, and Biogenesis....Pages 3-38
The Warburg Phenomenon and Other Metabolic Alterations of Cancer Cells....Pages 39-66
Mitochondrial Control of Apoptosis and Cancer....Pages 67-92
Mitochondrial-to-Nuclear Communications in Cancer....Pages 93-115
Front Matter....Pages 118-118
Types of Mitochondrial Genetic Alterations in Cancer....Pages 119-134
Mitochondrial Genetic Alterations in Cancer I....Pages 135-165
Mitochondrial Genetic Alterations in Cancer II....Pages 167-185
Mitochondrial Genome Rearrangements and Copy Number Changes in Cancer....Pages 187-212
Functional Importance of Mitochondrial Genetic Alterations in Cancer....Pages 213-236
The Role of Mitochondrial Reactive Oxygen Species in Cancer....Pages 237-256
Front Matter....Pages 258-258
Mitochondrial DNA Measurement in Exfoliated Cells for Cancer Detection and Monitoring: The Copy Number Advantage....Pages 259-274
Early Cancer Detection and Monitoring Using Changes in the Mitochondrial Genome as Biosensors....Pages 275-296
Analysis of Mitochondrial Genome Alterations in Cancer....Pages 297-319
“Mitocans”: Agents Targeting Mitochondria to Kill Cancer Cells....Pages 321-344
Back Matter....Pages 345-356
