What are the functions of mitochondria in the human body? Why might they stop working properly and what can happen as a result? How can personalized nutrition help to optimize mitochondrial function and prevent or address chronic conditions?
This innovative book explores the incredibly complex biochemical roles of mitochondria in health and disease. When healthy, mitochondria provide us with ninety percent of our body’s energy. When unhealthy, this can lead to many chronic and degenerative conditions including cancer and Alzheimer’s disease. This guide helps practitioners to identify the mitochondrial dysfunction underlying a wide range of health complaints, and provides inspiration about relevant and emerging mitochondria-supportive dietary regimes and nutrients to explore within the model of personalized nutrition.
Author(s): Ray Griffiths, Lorraine Nicolle
Series: Personalized Nutrition and Lifestyle Medicine for Healthcare Practitioners
Publisher: Singing Dragon
Year: 2018
Language: English
Pages: 334
City: London ; Philadelphia
Tags: Mitochondrial Diseases--diet therapy; Mitochondria--physiology; Mitochondria--metabolism; Adenosine Triphosphate--physiology; Mitochondria--pathology
Foreword by Lorraine Nicolle 7
Disclaimer 10
Abbreviations 11
Part I. Mitochondrial Functions: The Doorway to Understanding the Body as a Whole 13
1. What Are Mitochondria? 16
2. Enabling Evolution 22
3. Energy Production 30
4. Mitochondrial Dynamics 44
5. Maintaining Allostasis 62
6. Acetyl-CoA: A Vital Energy Source and Controller of a Cell 67
7. Synthesizing Cellular Components 73
8. Ketone Metabolism 80
9. Altering Immune Function 86
10. Creating Short Bursts of Rapid Energy 98
11. Calcium Storage and Regulation 100
12. Apoptosis: Programmed Cell Death 111
13. Haeme Production 114
14. Supporting Kidney Detoxification and Hormone Synthesis 118
15. Health, Toxicity and Hormesis 121
Part II. The Influence of Mitochondria in Disease 129
16. Diets to Support Mitochondrial Function 131
17. Laboratory Tests and Biomarkers Related to Mitochondrial Function 148
18. Insulin Resistance and Type 2 Diabetes 159
19. Hypertension 169
20. Heart Disease 177
21. Cholesterol Metabolism 185
22. Autoimmune Disease: The Emerging Field of Immunometabolism 194
23. Fatigue 202
24. Neurodegeneration 211
25. Cancer 222
26. Osteoarthritis 237
27. Osteoporosis 241
28. Chronic Pain 246
29. Depression 251
30. Autism Spectrum Disorders 259
Final Word 265
Appendix 1: Table of Fat Types 267
Appendix 2: Nutrient Dosage Ranges from Research Studies 268
Glossary 274
References 279
Subject Index 312
Author Index 328
