Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins. This book, Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy.
Author(s): Kjerstin M. Owens, J. S. Modica-Napolitano, Keshav K. Singh (auth.), Leslie Costello, Keshav Singh (eds.)
Edition: 1
Publisher: Springer-Verlag New York
Year: 2009
Language: English
Pages: 289
Tags: Cancer Research; Medical Microbiology; Molecular Medicine; Cell Biology; Biomedicine general; Laboratory Medicine
Front Matter....Pages i-xii
Mitochondria and Cancer....Pages 1-21
Warburg and his Legacy....Pages 23-38
The Lipogenic Switch in Cancer....Pages 39-59
Citrate Metabolism in Prostate and Other Cancers....Pages 61-78
Integration of Genetic, Proteomic, and Metabolic Approaches in Tumor Cell Metabolism....Pages 79-92
Mitochondrial Respiration and Differentiation....Pages 93-102
Integration of Energy Metabolism and Control of Apoptosis in Tumor Cells....Pages 103-129
Energy Generating Pathways and the Tumor Suppressor p53....Pages 131-150
Mitochondrial Tumor Suppressors....Pages 151-162
Mitochondria in Hematology....Pages 163-191
Mitochondria and Oncocytomas....Pages 193-209
Mitochondria as Targets for Cancer Therapy....Pages 211-249
Reversing the Warburg Effect: Metabolic Modulation as a Novel Cancer Therapy....Pages 251-264
Mitochondrial Nanotechnology for Cancer Therapy....Pages 265-279
Back Matter....Pages 281-289
