Preface
Contents
About the Editor
Chapter 1: Public Health
1.1 Epidemiology
Prevalence, burden, and clinical management of migraine in China, Japan, and South Korea: a comprehensive review of the literature
Incidence, prevalence and disability associated with neurological disorders in Italy between 1990 and 2019: an analysis based on the Global Burden of Disease Study 2019
Epidemiology, work and economic impact of migraine in a large hospital cohort: time to raise awareness and promote sustainability
Association of migraines with brain tumors: a nationwide population-based study
The prevalence of headache disorders in children and adolescents in Ethiopia: a schools-based study
The prevalence of headache disorders in children and adolescents in Mongolia: a nationwide schools-based study
Primary headache disorders among the adult population of Mongolia: prevalences and associations from a population-based survey
Prevalence and risk factors associated with headache amongst medical staff in South China
Prevalence and comorbidity of migraine headache: results from the Singapore Mental Health Study 2016
Prevalence of migraine in Upper Egypt
Migraine prevalence, clinical characteristics, and health care-seeking practice in a sample of medical students in Egypt
Primary headache disorders in the adult general population of Pakistan—a cross sectional nationwide prevalence survey
The prevalence of primary headache disorders in Saudi Arabia: a cross-sectional population-based study
Survival outcome and mortality rate in patients with migraine: a population-based cohort study
Major sex differences in migraine prevalence among occupational categories: a cross-sectional study using UK Biobank
1.2 Personal and Societal Burden
Migraine remains second among the world’s causes of disability, and first among young women: findings from GBD2019
Migraine is first cause of disability in under 50s: will health politicians now take notice?
21st Century Headache: Mapping New Territory
Burden of Migraine in Patients With Preventive Treatment Failure Attending European Headache Specialist Centers: Real-World Evidence From the BECOME Study
Global assessment of migraine severity measure: preliminary evidence of construct validity
Perceived stress in patients with migraine: a case-control study
The burden attributable to headache disorders in children and adolescents in Lithuania: estimates from a national schools-based study
Impact of primary headache disorder on quality of life among school students in Kuwait
Patients’ perspective on the burden of migraine in Europe: a cross-sectional analysis of survey data in France, Germany, Italy, Spain, and the United Kingdom
My migraine voice survey: a global study of disease burden among individuals with migraine for whom preventive treatments have failed
Burden and attitude to resistant and refractory migraine: a survey from the European Headache Federation with the endorsement of the European Migraine & Headache Alliance
Burden of migraine among japanese patients: a cross-sectional National Health and Wellness Survey
Burden of Migraine in Europe Using Self-Reported Digital Diary Data from the Migraine Buddy© Application
Burden of migraine in a Kuwaiti population: a door-to-door survey
Burden of migraine in Finland: health care resource use, sick-leaves and comorbidities in occupational health care
The burden of headache disorders in Ethiopia: national estimates from a population-based door-to-door survey
The burden of headache disorders in the Eastern Mediterranean Region, 1990–2016: findings from the Global Burden of Disease study 2016
Prevalence and burden of headache in children and adolescents in Austria—a nationwide study in a representative sample of pupils aged 10–18 years
Migraine: a major debilitating chronic non-communicable disease in Brazil, evidence from two national surveys
Undifferentiated headache: broadening the approach to headache in children and adolescents, with supporting evidence from a nationwide school-based cross-sectional survey in Turkey
Insufficient sleep is prevalent among migraineurs: a population-based study
Burden of migraine and unmet needs from the patients’ perspective: a survey across 11 specialized headache clinics in Korea
The Headache-Attributed Lost Time (HALT) Indices: measures of burden for clinical management and population-based research
The effect of maternal migraine headache on their children’s quality of life
Quality of life in children and adolescents with migraine: an Austrian monocentric, cross-sectional questionnaire study
Jealousy in women with migraine: a cross-sectional case-control study
Effect of Migraine Headache on Productivity of Patients According to Migraine Disability Assessment Score: A Cross-Sectional Study
A cross-sectional study on the burden and impact of migraine on work productivity and quality of life in selected workplaces in the Philippines
Reliability and validity of the 6-item Headache Impact Test in chronic migraine from the PROMISE-2 Study
1.3 Economics
Economic Evaluation of Treatments for Migraine: An Assessment of the Generalizability Following a Systematic Review
Headache in Resource-Limited Settings
The relationship between headache-attributed disability and lost productivity: 2. Empirical evidence from population-based studies in nine disparate countries
The Humanistic and Economic Burden of Migraine in Europe: A Cross-Sectional Survey in Five Countries
Cost of chronic and episodic migraine patients in continuous treatment for two years in a tertiary level headache Centre
Economic burden of migraine in Latvia and Lithuania: direct and indirect costs
Burden and costs of migraine in a Swedish defined patient population—a questionnaire-based study
A universal outcome measure for headache treatments, care-delivery systems and economic analysis
Validation of a self-reported instrument to assess work-related difficulties in patients with migraine: the HEADWORK questionnaire
The relationship between headache-attributed disability and lost productivity: 1. A review of the literature
Migraine day frequency in migraine prevention: longitudinal modelling approaches
Disability, quality of life, productivity impairment and employer costs of migraine in the workplace
Migraine treatment and healthcare costs: retrospective analysis of the China Health Insurance Research Association (CHIRA) database
Total health insurance costs in children with a migraine diagnosis compared to a control group
Economic consequences of migraine in Sweden and Implications for the cost-effectiveness of onabotulinumtoxinA (Botox) for chronic migraine in Sweden and Norway
My Migraine Voice survey: disease impact on healthcare resource utilization, personal and working life in Finland
Impact of migraine on workplace productivity and monetary loss: a study of employees in banking sector in Malaysia
Migraine Characteristics, Comorbidities, Healthcare Resource Utilization, and Associated Costs of Early Users of Erenumab in the USA: A Retrospective Cohort Study Using Administrative Claims Data
Care Among Migraine Patients in a Commercially Insured Population
Cost-Effectiveness of Erenumab for the Preventive Treatment of Migraine in Patients with Prior Treatment Failures in Sweden
Cost-Effectiveness Analysis of Erenumab Versus OnabotulinumtoxinA for Patients with Chronic Migraine Attacks in Greece
Costs of Acute Headache Medication Use and Productivity Losses Among Patients with Migraine: Insights from Three Randomized Controlled Trials
1.4 Governance
Structured headache services as the solution to the ill-health burden of headache: 1. Rationale and Description
Editorial. Valuing headache’s solution
Structured headache services as the solution to the ill-health burden of headache. 2. Modelling effectiveness and cost-effectiveness of implementation in Europe: methodology
Structured headache services as the solution to the ill-health burden of headache. 3. Modelling effectiveness and cost-effectiveness of implementation in Europe: findings and conclusions
Headache service quality evaluation: implementation of quality indicators in primary care in Europe
Poor medical care for people with migraine in Europe—evidence from the Eurolight study
Characteristics of Patients Referred to a Specialized Headache Clinic
Are doctors accurate when diagnosing themselves with migraine? A study on migraine prevalence among doctors in a tertiary care hospital
Shortcomings and missed potentials in the management of migraine patients—experiences from a specialized tertiary care center
Prevalence and burden of headache disorders in Lithuania and their public-health and policy implications: a population-based study within the Eurolight project
Lifting the burden of headache in China: managing migraine in a SMART way
References
Chapter 2: Mechanisms
2.1 Genetics
Advances in genetics of migraine
Polygenic risk score: use in migraine research
Genetics of migraine aura: an update
Migrainomics—identifying brain and genetic markers of migraine
Genetic and biochemical changes of the serotonergic system in migraine pathobiology
New CACNA1A deletions are associated to migraine phenotypes
Expression of PIAS Genes in Migraine Patients
Gamma-aminobutyric acid (GABA) receptors GABRA4, GABRE, and GABRQ gene polymorphisms and risk for migraine
Differential Expression of Cytokine-Coding Genes among Migraine Patients with and without Aura and Normal Subjects
A genetic interaction of NRXN2 with GABRE, SYT1 and CASK in migraine patients: a case-control study
Changes in the gene expression profile during spontaneous migraine attacks
The NRP1 migraine risk variant shows evidence of association with menstrual migraine
New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis
TRPM8 genetic variant is associated with chronic migraine and allodynia
Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses
Searching for Predictors of Migraine Chronification: a Pilot Study of 1911A>G Polymorphism of TRPV1 Gene in Episodic Versus Chronic Migraine
Implications for the migraine SNP rs1835740 in a Swedish cluster headache population
rs2651899 variant is associated with risk for migraine without aura from North Indian population
CALCA and TRPV1 genes polymorphisms are related to a good outcome in female chronic migraine patients treated with OnabotulinumtoxinA
A genetic risk score is differentially associated with migraine with and without aura
Identifying genetic variants for age of migraine onset in a Han Chinese population in Taiwan
Association of MTHFR gene polymorphisms with migraine in North Indian population
A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine
2.2 Biology
Migraine Aura: Updates in Pathophysiology and Management
Mechanisms of migraine as a chronic evolutive condition
Hypothalamus loses control in migraine
The metabolic face of migraine—from pathophysiology to treatment
From transformation to chronification of migraine: pathophysiological and clinical aspects
Biological insights from the premonitory symptoms of migraine
Behavioral and cognitive animal models in headache research
Potassium channel openers—novel triggers of aura and migraine
Aura and Head pain: relationship and gaps in the translational models
Plasma levels of CGRP and expression of specific microRNAs in blood cells of episodic and chronic migraine subjects: towards the identification of a panel of peripheral biomarkers of migraine?
Metabolic profile changes in serum of migraine patients detected using 1H-NMR spectroscopy
Increased nitroglycerin-mediated vasodilation in migraineurs without aura in the interictal period
Intravascular Endothelin-1 does not trigger or increase susceptibility to Spreading Depolarizations
Auditory brainstem function in women with vestibular migraine: a controlled study
Altered muscle activity during rest and during mental or physical activity is not a trait symptom of migraine—a neck muscle EMG study
Fluctuations in local and widespread mechanical sensitivity throughout the migraine cycle: a prospective longitudinal study
Clinical relevance of depressed kynurenine pathway in episodic migraine patients: potential prognostic markers in the peripheral plasma during the interictal period
Hypoechogenicity of brainstem raphe correlates with depression in migraine patients
High asymmetric dimethylarginine, symmetric dimethylarginine and L-arginine levels in migraine patients
The integration of multisensory motion stimuli is impaired in vestibular migraine patients
Duration and frequency of migraines affect cognitive function: evidence from neuropsychological tests and event-related potentials
Olfactory bulbus volume and olfactory sulcus depth in migraine patients: an MRI evaluation
2.3 Comorbidities
Comorbidities of primary headache disorders: a literature review with meta-analysis
Comorbid and co-occurring conditions in migraine and associated risk of increasing headache pain intensity and headache frequency: results of the migraine in America symptoms and treatment (MAST) study
Psychiatric and cognitive comorbidities of persistent post-traumatic headache attributed to mild traumatic brain injury
Association Between Obesity and Migraine in Women
Interrelations between migraine-like headache and persistent post-traumatic headache attributed to mild traumatic brain injury: a prospective diary study
Prevalence and comorbidity of migraine headache: results from the Singapore Mental Health Study 2016
Migraine as a risk factor for young patients with ischemic stroke: a case–control study
Comorbidity of gastrointestinal disorders, migraine, and tension-type headache: a cross-sectional study in Iran
Comorbidity of migraine with ADHD in adults
Association Between Benign Positional Vertigo and Migraine in Indian Population
The Burden of Migraine in Adults with Atrial Septal Defect: A Nationwide Cohort Study
Migraine and tension headache comorbidity with hypothyroidism in Egypt
Stroke and cardiovascular risk factors among working-aged Finnish migraineurs
Migraine in Chiari 1 Malformation: a cross-sectional, single centre study
Headache in the course of multiple sclerosis: a prospective study
Vestibular drop attacks in Ménière’s disease and its association with migraine
The prevalence of papilledema in patients with migraine: a crucial cooccurrence of migraine and idiopathic intracranial hypertension
Coronary artery calcification score in migraine patients
The relationship between migraine headache and asthma features
Migraine and increased risk of developing open angle glaucoma: a population-based cohort study
Relationship between migraine headache and hematological parameters
The relationship with restless legs syndrome, fibromyalgia, and depressive symptoms in migraine patients
Migraine and subclinical atherosclerosis: endothelial dysfunction biomarkers and carotid intima-media thickness: a case-control study
2.4 Lifestyle
Health Behaviors in Episodic Migraine: Why Behavior Change Matters
Exercise and Migraine Prevention: a Review of the Literature
The association between migraine and physical exercise
Triggers, Protectors, and Predictors in Episodic Migraine
A Clinical Approach to Addressing Diet with Migraine Patients
Level of physical activity, well-being, stress and self-rated health in persons with migraine and co-existing tension-type headache and neck pain
The Association Between Dietary Acid Load and Odds of Migraine: A Case–Control Survey
Fruit and vegetable consumption in relation to primary headaches: the MEPHASOUS study
A ketogenic diet normalizes interictal cortical but not subcortical responsivity in migraineurs
The association between dietary tryptophan intake and migraine
Migraine headaches and fragranced consumer products: an international population-based study
Clinical characteristics of sleep disorders in patients with vestibular migraine
2.5 Hormones
Effect of exogenous estrogens and progestogens on the course of migraine during reproductive age: a consensus statement by the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESCRH)
Hormonal contraceptives and risk of ischemic stroke in women with migraine: a consensus statement from the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESC)
Male and female sex hormones in primary headaches
Women and Migraine: the Role of Hormones
Hormonal effect on the relationship between migraine and female sexual dysfunction
Sexual dysfunction and distress in premenopausal women with migraine: association with depression, anxiety and migraine-related disability
Migraine start, course and features over the cycle of combined hormonal contraceptive users with menstrual migraine—temporal relation to bleeding and hormone withdrawal: a prospective diary-based study
Effects of estrogen and progesterone on the neurogenic inflammatory neuropeptides: implications for gender differences in migraine
The distribution of oxytocin and the oxytocin receptor in rat brain: relation to regions active in migraine
Clinical symptoms of androgen deficiency in men with migraine or cluster headache: a cross-sectional cohort study
High rates of (treated) hypothyroidism among chronic migraine patients consulting a specialized headache clinic: are we missing something?
References
Chapter 3: Diagnosis
3.1 Classification
European headache federation consensus on the definition of resistant and refractory migraine
Experts’ opinion about the primary headache diagnostic criteria of the ICHD-3rd edition beta in children and adolescents
ICHD-3 is significantly more specific than ICHD-3 beta for diagnosis of migraine with aura and with typical aura
Primary Stabbing Headache
Automatic migraine classification via feature selection committee and machine learning techniques over imaging and questionnaire data
Machine learning-based automated classification of headache disorders using patient-reported questionnaires
Validation of an algorithm for automated classification of migraine and tension-type headache attacks in an electronic headache diary
Classifying migraine subtypes and their characteristics by latent class analysis using data of a nation-wide population-based study
Need of guidance in disabling and chronic migraine identification in the primary care setting, results from the european MyLife anamnesis survey
Exploring Natural Clusters of Chronic Migraine Phenotypes: A Cross-Sectional Clinical Study
Characteristics of headache disorders, according to ICHD-III in an outpatient headache clinic in Sohag Governorate, Egypt
3.2 Medical history
Primary headaches during lifespan
Clinical features of visual migraine aura: a systematic review
Cognitive dysfunction and migraine
Migraine in Children Under 7 Years of Age: a Review
Cyclic Vomiting Syndrome in Children
Premonitory Symptoms of Migraine in Childhood and Adolescence
Are some patient-perceived migraine triggers simply early manifestations of the attack?
Fluctuations in episodic and chronic migraine status over the course of 1 year: implications for diagnosis, treatment and clinical trial design
Prolonged migraine aura: new insights from a prospective diary-aided study
Headache Gauge: a real-life calendar-based tool for headache monitoring
Dilemma of migraine diagnosis and management among non-neurologists
3.3 Clinical Diagnosis
Diagnosis and management of migraine in ten steps
Reference programme: diagnosis and treatment of headache disorders and facial pain. Danish Headache Society, 3rd edition, 2020
Migraine as a Stroke Mimic and as a Stroke Chameleon
Differentiating migraine, cervicogenic headache and asymptomatic individuals based on physical examination findings: a systematic review and meta-analysis
The Hypertensive Headache: a Review
Sleep disorder-related headaches
Pressure pain thresholds over the cranio-cervical region in headache: a systematic review and meta-analysis
The validation of the Hungarian version of the ID-migraine questionnaire
Migraine screen questionnaire: further psychometric evidence from categorical data methods
Characterization of migraineurs presenting interictal widespread pressure hyperalgesia identified using a tender point count: a cross-sectional study
Characteristic differences between vestibular migraine and migraine only patients
RCVS–TCH score can predict reversible cerebral vasoconstriction syndrome in patients with thunderclap headache
3.4 Neuroimaging
Structural and Functional Brain Changes in Migraine
Functional connectivity studies in migraine: what have we learned?
Neuroimaging clues of migraine aura
Understanding migraine as a cycling brain syndrome: reviewing the evidence from functional imaging
Disconnectome of the migraine brain: a “connectopathy” model
Altered structural brain network topology in chronic migraine
Evaluation of migraine patients with optical coherence tomography angiography
Diffusion tensor imaging in middle-aged headache sufferers in the general population: a cross-sectional population-based imaging study in the Nord-Trøndelag health study (HUNT-MRI)
Cerebral sodium (23Na) magnetic resonance imaging in patients with migraine—a case-control study
A volumetric magnetic resonance imaging study in migraine
Hyperconnection and hyperperfusion of overlapping brain regions in patients with menstrual-related migraine: a multimodal neuroimaging study
Cortical metabolic and structural differences in patients with chronic migraine. An exploratory 18FDG-PET and MRI study
Evidence of an increased neuronal activation-to-resting glucose uptake ratio in the visual cortex of migraine patients: a study comparing 18FDG-PET and visual evoked potentials
Topographic changes measured by the swept source optical coherence tomography in retinal nerve fiber layer, optic nerve head and macula in children with migraine
Retinal vascular density evaluation of migraine patients with and without aura and association with white matter hyperintensities
Multimodal MRI-based classification of migraine: using deep learning convolutional neural network
3.5 Medication Overuse and Addiction
Medication overuse and drug addiction: a narrative review from addiction perspective
Factors associated with acute medication overuse in people with migraine: results from the 2017 migraine in America symptoms and treatment (MAST) study
Enhanced functional connectivity between habenula and salience network in medication-overuse headache complicating chronic migraine positions it within the addiction disorders: an ICA-based resting-state fMRI study
Volumetric abnormalities of thalamic subnuclei in medication-overuse headache
Volume gain of periaqueductal gray in medication-overuse headache
The role of personality, disability and physical activity in the development of medication-overuse headache: a prospective observational study
Chronic Migraine with Medication Overuse: Clinical Pattern and Evolution from a Retrospective Cohort in Seville, Spain
Psychoactive substances as a last resort—a qualitative study of self-treatment of migraine and cluster headaches
Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort
Alteration of gray matter texture features over the whole brain in medication-overuse headache using a 3-dimentional texture analysis
FRAMES protocol versus simple advice for medication-overuse headache: a prospective, randomized, controlled clinical trial
Polypharmacy Among Headache Patients: A Cross-Sectional Study
Association between suicidal risks and medication-overuse headache in chronic migraine: a cross-sectional study
Use and overuse of triptans in Austria – a survey based on nationwide healthcare claims data
Withdrawal from acute medication normalises short-term cortical synaptic potentiation in medication overuse headache
Treatment of withdrawal headache in patients with medication overuse headache: a pilot study
References
Chapter 4: Treatment
4.1 Acute Treatment
Recent Advances in Pharmacotherapy for Episodic Migraine
Improving Medication Adherence in Migraine Treatment
Ubrogepant: First Approval
Rimegepant: First Approval
Lasmiditan: First Approval
Safety and Efficacy of Ubrogepant for the Acute Treatment of Episodic Migraine: A Meta-Analysis of Randomized Clinical Trials
Rimegepant orally disintegrating tablets in the acute treatment of migraine: a profile of their use
Lasmiditan mechanism of action – review of a selective 5-HT1F agonist
A global real-world assessment of the impact on health-related quality of life and work productivity of migraine in patients with insufficient versus good response to triptan medication
A Framework for Estimating the Eligible Patient Population for New Migraine Acute Therapies in the United States
Unmet Needs in Japanese Patients Who Report Insufficient Efficacy with Triptans for Acute Treatment of Migraine: Retrospective Analysis of Real-World Data
A real-world study on unmet medical needs in triptan-treated migraine: prevalence, preventive therapies and triptan use modification from a large Italian population along two years
Ubrogepant for the Acute Treatment of Migraine: Pooled Efficacy, Safety, and Tolerability From the ACHIEVE I and ACHIEVE II Phase 3 Randomized Trials
Mapping Migraine-Specific Quality of Life to Health State Utilities in Patients Receiving Rimegepant
Effect of a rescue or recurrence dose of lasmiditan on efficacy and safety in the acute treatment of migraine: findings from the phase 3 trials (SAMURAI and SPARTAN)
Trajectory of migraine-related disability following long-term treatment with lasmiditan: results of the GLADIATOR study
Safety findings from CENTURION, a phase 3 consistency study of lasmiditan for the acute treatment of migraine
Long term safety, tolerability, and efficacy of intracutaneous zolmitriptan (M207) in the acute treatment of migraine
Efficacy of triptans for the treatment of acute migraines: a quantitative comparison based on the dose-effect and time-course characteristics
DFN-02, Sumatriptan 10 mg Nasal Spray with Permeation Enhancer, for the Acute Treatment of Migraine: A Randomized, Double-Blind, Placebo-Controlled Study Assessing Functional Disability and Subject Satisfaction with Treatment
Effectiveness of intravenous dexamethasone, metoclopramide, ketorolac, and chlorpromazine for pain relief and prevention of recurrence in the migraine headache: a prospective double-blind randomized clinical trial
4.2 Preventive Treatment
European headache federation guideline on the use of monoclonal antibodies acting on the calcitonin gene related peptide or its receptor for migraine prevention
Erenumab: First Global Approval
Galcanezumab: First Global Approval
Eptinezumab: First Approval
Atogepant: First Approval
Efficacy and Safety of Galcanezumab for the Preventive Treatment of Migraine: A Narrative Review
Calcitonin gene-related peptide (receptor) antibodies: an exciting avenue for migraine treatment
Shaping the future of migraine targeting Calcitonin-Gene-Related-Peptide with the Disease-Modifying Migraine Drugs (DMMDs)
“Triaging” Chronic Migraine Patients in Need of CGRP(r) Monoclonal Antibodies
InterMiG: international differences in the therapeutic approach to migraine patients in specialized headache centers
Anti-CGRP monoclonal antibodies in chronic migraine with medication overuse: real-life effectiveness and predictors of response at 6 months
The impact of anti-CGRP monoclonal antibodies in resistant migraine patients: a real-world evidence observational study
Effectiveness and Safety of CGRP-mAbs in Menstrual-Related Migraine: A Real-World Experience
Physician and patient preferences for dosing options in migraine prevention
Patient Perspectives and Experiences of Preventive Treatments and Self-Injectable Devices for Migraine: A Focus Group Study
Real world preventative drug management of migraine among Spanish neurologists
Real-world evidence data on the monoclonal antibody erenumab in migraine prevention: perspectives of treating physicians in Germany
Real-World Trends in Characteristics of Patients with Migraine Newly Initiated on Erenumab in the USA: A Retrospective Analysis
Erenumab in highly therapy-refractory migraine patients: First German real-world evidence
Efficacy and safety of erenumab in women with a history of menstrual migraine
A prospective real-world analysis of erenumab in refractory chronic migraine
4.3 Results
Erenumab and galcanezumab in chronic migraine prevention: effects after treatment termination
A phase 3, long-term, open-label safety study of Galcanezumab in patients with migraine
Galcanezumab in episodic migraine: subgroup analyses of efficacy by high versus low frequency of migraine headaches in phase 3 studies (EVOLVE-1 & EVOLVE-2)
Instrumental assessment of physiotherapy and onabolulinumtoxin-A on cervical and headache parameters in chronic migraine
Onabotulinumtoxin A for the management of chronic migraine in current clinical practice: results of a survey of sixty-three Italian headache centers
Early Management of OnabotulinumtoxinA Treatment in Chronic Migraine: Insights from a Real-Life European Multicenter Study
Botulinum toxin injection in the management of chronic migraine: the Saudi experience with a proposal for a new protocol
Triptan efficacy does not predict onabotulinumtoxinA efficacy but improves with onabotulinumtoxinA response in chronic migraine patients
The efficacy of magnesium oxide and sodium valproate in prevention of migraine headache: a randomized, controlled, double-blind, crossover study
A combination of coenzyme Q10, feverfew and magnesium for migraine prophylaxis: a prospective observational study
Clinical success of greater occipital nerve blockade in improving sleep quality of chronic migraineurs: a prospective observational study
4.4 Emergency Department Management
Emergency Department and Inpatient Management of Headache in Adults
Acute headache management in emergency department. A narrative review
Emergency Neurological Life Support: Subarachnoid Hemorrhage
Emergency Neurologic Life Support: Meningitis and Encephalitis
Optimal management strategies for primary headache in the emergency department
Relationship between air mass type and emergency department visits for migraine headache across the Triangle region of North Carolina
Acute migraine management in the emergency department: experience from a large Spanish tertiary hospital
Lost diagnoses in not otherwise specified headache in Emergency Department
Adherence to guidelines of treatment of non-traumatic headache in the emergency department
4.5 Pregnancy
Migraine Treatment in Pregnancy and Lactation
Patterns and predictors of analgesic use in pregnancy: a longitudinal drug utilization study with special focus on women with migraine
Medicines for headache before and during pregnancy: a retrospective cohort study (ATENA study)
The impact of pregnancy on headache evaluation in the emergency department, a retrospective cohort study
Migraine and the risk of post-traumatic stress disorder among a cohort of pregnant women
OnabotulinumtoxinA for chronic migraine during pregnancy: a real world experience on 45 patients
The Use of Behavioral Modalities for Headache During Pregnancy and Breastfeeding
4.6 Neuromodulation
Practical and clinical utility of non-invasive vagus nerve stimulation (nVNS) for the acute treatment of migraine: a post hoc analysis of the randomized, sham-controlled, double-blind PRESTO trial
Remote electrical neuromodulation (REN) in the acute treatment of migraine: a comparison with usual care and acute migraine medications
Alleviation of migraine symptoms by application of repetitive peripheral magnetic stimulation to myofascial trigger points of neck and shoulder muscles – A randomized trial
Neuronavigation based 10 sessions of repetitive transcranial magnetic stimulation therapy in chronic migraine: an exploratory study
Cortical Mechanisms of Single-Pulse Transcranial Magnetic Stimulation in Migraine
The role of left prefrontal transcranial magnetic stimulation in episodic migraine prophylaxis
Occipital Nerve Stimulation in Chronic Migraine: The Relationship Between Perceived Sensory Quality, Perceived Sensory Location, and Clinical Efficacy—A Prospective, Observational, Non-Interventional Study
Peripheral nerve stimulation registry for intractable migraine headache (RELIEF): a real-life perspective on the utility of occipital nerve stimulation for chronic migraine
Clinical experience with transcutaneous supraorbital nerve stimulation in patients with refractory migraine or with migraine and intolerance to topiramate: a prospective exploratory clinical study
4.7 Complementary Alternative Medicine
A critical review of manual therapy use for headache disorders: prevalence, profiles, motivations, communication and self-reported effectiveness
Usefulness of nutraceuticals in migraine prophylaxis
Ketogenic diet in migraine: rationale, findings and perspectives
Patient feedback for acupuncture practice improvement: A survey from Mayo Clinic
4.8 Psycho-Behavioral Interventions
Neuropsychological assessment in migraine patients: a descriptive review on cognitive implications
Pain cognition in migraine: from basic neurophysiology to a behavioral paradigm
Health Behaviors in Episodic Migraine: Why Behavior Change Matters
Using Cognitive Behavioral Therapy Techniques to Treat Migraine
Underuse of Behavioral Treatments for Headache: a Narrative Review Examining Societal and Cultural Factors
Adherence to Behavioral Therapy for Migraine: Knowledge to Date, Mechanisms for Assessing Adherence, and Methods for Improving Adherence
Efficacy and Feasibility of Behavioral Treatments for Migraine, Headache, and Pain in the Acute Care Setting
ACT for migraine: effect of acceptance and commitment therapy (ACT) for high-frequency episodic migraine without aura: preliminary data of a phase-II, multicentric, randomized, open-label study
Mindfulness and pharmacological prophylaxis after withdrawal from medication overuse in patients with Chronic Migraine: an effectiveness trial with a one-year follow-up
4.9 Childhood and Adolescent
Migraine in childhood: an organic, biobehavioral, or psychosomatic disorder?
The use of nutraceutics in children‘s and adolescent’s headache
Comparison of a pediatric practice-based therapy and an interdisciplinary ambulatory treatment in social pediatric centers for migraine in children: a nation-wide randomized-controlled trial in Germany: “moma – modules on migraine activity”
Treatment of disabling headache with greater occipital nerve injections in a large population of childhood and adolescent patients: a service evaluation
Paracetamol versus Ibuprofen for the Acute Treatment of Migraine Headache in Children: A Blinded Randomized Controlled Trial
Pharmacokinetics, Safety, and Tolerability of Lasmiditan in Pediatric Patients with Migraine
References
Chapter 5: Future Directions
5.1 Post-concussion Syndrome
Position Paper on Post-Traumatic Headache: The Relationship Between Head Trauma, Stress Disorder, and Migraine
Post-traumatic headache: epidemiology and pathophysiological insights
Persistent post-traumatic headache: a migrainous loop or not? The preclinical evidence
Persistent post-traumatic headache: a migrainous loop or not? The clinical evidence
Post-traumatic Stress Disorder After Traumatic Brain Injury—A Systematic Review and Meta-Analysis
Post-traumatic Headache in Children and Adolescents
Mild traumatic brain injury affects the features of migraine
Factors Associated with Sport-Related Post-concussion Headache and Opportunities for Treatment
Utilizing the Biopsychosocial Model in Concussion Treatment: Post-Traumatic Headache and beyond
Exploring naturally occurring clinical subgroups of post-traumatic headache
Imaging Post-Traumatic Headache
Pharmacotherapy for Persistent Posttraumatic Headaches in Children and Adolescents: A Brief Review of the Literature
Acute and preventive pharmacological treatment of post-traumatic headache: a systematic review
Psychiatric and cognitive comorbidities of persistent post-traumatic headache attributed to mild traumatic brain injury
Interrelations between migraine-like headache and persistent post-traumatic headache attributed to mild traumatic brain injury: a prospective diary study
The role of deficient pain modulatory systems in the development of persistent post-traumatic headaches following mild traumatic brain injury: an exploratory longitudinal study
Altered speech patterns in subjects with post-traumatic headache due to mild traumatic brain injury
Persistent post-traumatic headache vs. migraine: an MRI study demonstrating differences in brain structure
Decreased grey matter volume in mTBI patients with post-traumatic headache compared to headache-free mTBI patients and healthy controls: a longitudinal MRI study
Altered static and dynamic functional network connectivity in post-traumatic headache
Altered hypothalamic functional connectivity in post-traumatic headache after mild traumatic brain injury
Efficacy, tolerability, and safety of erenumab for the preventive treatment of persistent post-traumatic headache attributed to mild traumatic brain injury: an open-label study
5.2 COVID-19 and SARS-COV2 Vaccines
Navigating migraine care through the COVID-19 pandemic: an update
Coronavirus disease-19 and headache; impact on pre-existing and characteristics of de novo: a cross-sectional study
The impact of Coronavirus disease 2019 (COVID-19) pandemic on migraine disorder
Frequency and phenotype of headache in covid-19: a study of 2194 patients
Headache characteristics in COVID-19 pandemic-a survey study
Chronic migraine in the first COVID-19 lockdown: the impact of sleep, remote working, and other life/psychological changes
Characterization of Headache in COVID-19: a Retrospective Multicenter Study
The impact of COVID-19 pandemic on headache symptoms and drug withdrawal among patients with medication overuse headache: a cross-sectional study
The status and high risk factors of severe psychological distress in migraine patients during nCOV-2019 outbreak in Southwest China: a cross-sectional study
Impact of COVID-19 pandemic on migraine management in the United States: insights from migraine tracking app users
Hospital-based headache care during the Covid-19 pandemic in Denmark and Norway
Impact of the COVID-19 pandemic on migraine in Japan: a multicentre cross-sectional study
Overall trend towards headache remission during the COVID-19 pandemic among Chinese patients with pre-existing headache highlights the role of family support
Effects of the onabotulinumtoxinA follow-up delay in migraine course during the COVID-19 lockdown
Indomethacin for refractory COVID or post-COVID headache: a retrospective study
Headache Attributed to Vaccination Against COVID-19 (Coronavirus SARS-CoV-2) with the ChAdOx1 nCoV-19 (AZD1222) Vaccine: A Multicenter Observational Cohort Study
Delayed headache after COVID-19 vaccination: a red flag for vaccine induced cerebral venous thrombosis
Status migrainosus: a potential adverse reaction to Comirnaty (BNT162b2, BioNtech/Pfizer) COVID-19 vaccine—a case report
5.3 Tele-Medicine
Towards eHealth to support the health journey of headache patients: a scoping review
Telemedicine in Pediatric Headache: A Review and Practical Implementation
Disruptions of neurological services, its causes and mitigation strategies during COVID-19: a global review
Digital Technology and Mobile Health in Behavioral Migraine Therapy: a Narrative Review
Optimizing telemedical care in neurological outpatients by characterizing the patients’ needs in the physician–patient relationship—content analysis of guideline-based interviews
Primary headaches during the COVID-19 lockdown in Germany: analysis of data from 2325 patients using an electronic headache diary
References
