The 25th Jerusalem Symposium represents a most significant highlight in the development and history of these meetings. Living within the decimal system we have celebrated with much pleasure the lath and the 20th Jerusalem Symposia. With this one we experience a feeling of particular satisfaction because 25 years is different from, is more than, two decades and a half. It is a quarter of a century. It seems thus as if we have changed the dimension of our endeavour. In no way do we loose the sense of modesty with respect to the significance of these meetings. For the organizers, however, they do represent a continuity of efforts which we feel happy to have been able to carry out. At this occasion it seems useful to say a few words about the origin of the Jerusalem Symposia and to recall the name of a colleague who played an essential role in their creation and has been a most efficient and devoted co organizer of the seven first of them. This was Professor Ernst Bergmann, one of the most distinguished founders of Israeli Science and a world famous physico-organic chemist.
Author(s): R. M. Glaeser (auth.), Alberte Pullman, Joshua Jortner, Bernard Pullman (eds.)
Series: The Jerusalem Symposia on Quantum Chemistry and Biochemistry 25
Edition: 1
Publisher: Springer Netherlands
Year: 1992
Language: English
Pages: 506
Tags: Biochemistry, general; Physical Chemistry
Front Matter....Pages i-x
Electron Crystallography of Membrane Proteins....Pages 1-9
High-Resolution Electron Microscopy of Membrane Proteins....Pages 11-15
Distinguishing Transmembrane Helices from Peripheral Helices by Circular Dichroism....Pages 17-38
High-Resolution NMR of Membrane Proteins: The Example of Bacteriorhodopsin....Pages 39-45
Molecular Dynamics Simulations of Bacteriorhodopsin....Pages 47-60
Dynamics of Bacteriorhodopsin Studied by Neutron Scattering: Effects of the Environment, Softness and Structure....Pages 61-67
What Do Neutrons, X-ray Synchrotron Radiation, Optical ph-indicators, and Mutagenesis Tell us About the Light-driven Proton Pump Bacteriorhodopsin?....Pages 69-84
From Time-Resolved Difference Spectra to Kinetics, Mechanism, and Thermodynamics in the Bacteriorhodopsin Photocycle....Pages 85-96
Arginine 175 is Part of an Anion Binding Site in Bacteriorhodopsin....Pages 97-106
Electrostatic Calculations of the pK a ’s of Ionizable Groups in Bacteriorhodopsin....Pages 107-114
Dimerization of Glycophorin a Transmembrane Helices: Mutagenesis and Modeling....Pages 115-125
The Nicotinic Acetylcholine Receptor, A Model of Ligand-Gated Ion Channels....Pages 127-146
Molecular Evolution of the Binding Site of the Nicotinic Acetylcholine Receptor....Pages 147-160
3-D Structure of Acetylcholinesterase and Complexes of it with Anticholinesterase Agents....Pages 161-175
Modelling and Mutagenesis of Butyrylcholinesterase Based on the X-Ray Structure of Acetylcholinesterase....Pages 177-184
The Nicotinic Acetylcholine Receptor and its Lipid Microenvironment....Pages 185-198
A Correlation Between Patch Clamp and Fluorescence Anisotropy Experiments to Study Alterations on the Acethylcholine Channel Induced by Cholesterol Enrichment in Chick Myocytes....Pages 199-212
Interaction of the Nicotinic Acetylcholine Receptor with Ligands and Membrane Lipids Studied by Fourier-Transform Infrared Spectroscopy and Photoaffinity Labeling....Pages 213-227
On the Complexation of the Methylammonium Ion by Aromatic Side Chains of Proteins....Pages 229-232
The Inhibitory Glycine Receptor: Structure-Function Studies on a Neuronal Chloride Channel....Pages 233-239
Determinants of Ligand Binding to the Inhibitory Glycine Receptor....Pages 241-247
Channel Proteins: From Anatomy to Design....Pages 249-268
Linking Permeation Behavior and Structure of Ion Channels with a Microscopic Model....Pages 269-278
Molecular Structure-Function Relations in Voltage-Gated Ion Channels of Excitable Membranes....Pages 279-296
A Novel Model for Saturation of Ion Conductivity in Transmembrane Channels....Pages 297-314
Computational Approaches to Understanding the Ion Channel-Lipid System....Pages 315-338
A Minimal Model of Ion Channels: Polyamino Acids in Liposomes....Pages 339-356
Structure and Dynamics of Melittin in Solution and Membranes from Amide Hydrogen Exchange Analysis....Pages 357-366
Computer Modelling of Ion Binding Sites in Proteins....Pages 367-382
Sec-Dependent and Sec-Independent Mechanisms of Protein Insertion into Bacterial Membranes....Pages 383-391
Puncturing Cell Membranes: Comparison of Colicin A and Aerolysin....Pages 393-401
Structure-Function Relationships in the Membrane Channel Porin as Based on a 1.8 Å Resolution Crystal Structure....Pages 403-412
Molecular Mechanism of Action of Pore-Forming Colicins and of their Immunity Proteins....Pages 413-425
Preliminary Structural Studies of Photosystem I....Pages 427-441
Problems and Progress in Computational Approaches to the Molecular Basis of Recognition....Pages 443-447
Assembly of Escherichia Coli Inner Membrane Proteins: Sec-Dependent and Sec -Independent Membrane Insertion....Pages 449-455
Molecular Dynamics Simulations of Phospholipid Membranes and Their Interaction with Phospholipase A 2 ....Pages 457-470
Electron Transfer in Bacterial Photosynthetic Reaction Centers....Pages 471-479
Proton Transfer Pathways in Photosynthetic Reaction Centers Studied by Site-Directed Mutagenesis....Pages 481-495
Back Matter....Pages 497-506
