Mechanobiology of Cell-Cell and Cell-Matrix Interactions focuses on characterization and modeling of interactions between cells and their local extracellular environment, exploring how these interactions may mediate cell behavior. Studies of cell-matrix interactions rely on integrating engineering, biology, and imaging disciplines. Recent advances in the field have begun to unravel our understanding of how cells gather information from their surrounding environment, and how they interrogate such information during the cell fate decision making process. All these new developments are discussed in this volume, and the book also:
- Provides an examination of the mechanobiology of cell-matrix interactions
- Discusses the emerging area of cooperative behavior of cells, as well as current methods for probing cell mechanics
- Explores the mechano-pathology of cancer and disease
Other topics include adhesive and integrin-ligand interactions, extracellular influences on cell biology and behavior and the mechanobiology of pathological processes, among others. Mechanobiology of Cell-Matrix Interactions is an ideal book for researchers and engineers working in biomedical engineering and related fields.
Author(s): Andrew D. Rape, Wei-Hui Guo, Yu-Li Wang (auth.), A. Wagoner Johnson, Brendan A.C. Harley (eds.)
Edition: 1
Publisher: Springer US
Year: 2011
Language: English
Pages: 319
Tags: Biomedical Engineering;Biophysics and Biological Physics;Cell Biology
Front Matter....Pages i-xiii
Responses of Cells to Adhesion-Mediated Signals: A Universal Mechanism....Pages 1-10
Substrate Elasticity as a Probe to Measure Mechanosensing at Cell-Cell and Cell-Matrix Junctions....Pages 11-22
A Role for Integrin-ECM Bonds as Mechanotransducers that Modulate Adult Stem Cell Fate....Pages 23-46
Cell-Generated Forces in Tissue Assembly, Function, and Disease....Pages 47-74
Cell-Cell Interactions and the Mechanics of Cells and Tissues Observed in Bioartificial Tissue Constructs....Pages 75-103
Specific and Non-Specific Adhesion in Cancer Cells with Various Metastatic Potentials....Pages 105-122
Systems Biology of Tumor Cell Migration in 3D: Protein Signaling....Pages 123-149
Development of Three-Dimensional Tumor Models for the Study of Anti-Cancer Drug Effects....Pages 151-168
Mechanobiology of Epidermal Keratinocytes: Desmosomes, Hemidesmosomes, Keratin Intermediate Filaments, and Blistering Skin Diseases....Pages 169-210
Quantifying Cell-Matrix Deformations in Three Dimensions....Pages 211-232
Tools for Studying Biomechanical Interactions in Cells....Pages 233-265
Biomaterials for Studies in Cellular Mechanotransduction....Pages 267-277
Optical Sensing of Red Blood Cell Dynamics....Pages 279-309
Back Matter....Pages 311-319
