(Pending)
The mechanisms of the various forms of glaucoma were unknown at the outset of the twentieth century. Late in the twentieth century, two nascent areas of research were beginning to provide glimpses of what the twenty-first century held in store for the future of glaucoma: the mechanisms of glaucomatous optic neuropathy and the molecular basis of the glaucomas. In Mechanisms of the Glaucomas: Disease Processes and Therapeutic Modalities, the authors review the most current knowledge available in the field and provide a basis in which researchers can effectively study the glaucomas. The intent of the book is not primarily to describe the clinical appearances of the glaucomas nor how to manage them. Rather, it is to provide basic scientists, who are working in the field of glaucoma, with a current understanding of the clinical aspects of glaucoma, and to provide clinician scientists with the basic knowledge, as they attempt to translate it into rational treatments for glaucoma. In this important new book leaders in the various fields of glaucoma review our current understanding of glaucoma from epidemiology and genetics through molecular, cellular and tissue responses to the mechanisms of the glaucomas and the mechanisms by which we manage them. Mechanisms of the Glaucomas: Disease Processes and Therapeutic Modalities will be of great value as its contents will aid the reader in prevention of blindness from glaucoma.
Author(s): Joshua D. Stein MD, MS, Paul P. Lee MD, JD (auth.), Joyce Tombran-Tink PhD, Colin J. Barnstable DPhil, M. Bruce Shields MD (eds.)
Series: Ophthalmology Research™
Edition: 1
Publisher: Humana Press
Year: 2008
Language: English
Pages: 762
Tags: Ophthalmology
Front Matter....Pages I-XIX
Front Matter....Pages 1-1
Age and Racial Variation in the Prevalence of Open-Angle Glaucoma in the USA....Pages 3-17
Epidemiology of and Risk Factors for Primary Open-Angle Glaucoma....Pages 19-33
The Reykjavik Eye Study on Prevalence of Glaucoma in Iceland and IdentifiedRisk Factors....Pages 35-47
Defined Glaucoma in Chinese Population....Pages 49-61
The Wroclaw Epidemiological Study: Screening Possibilities of Glaucoma Detection....Pages 63-79
Front Matter....Pages 81-82
Pretrabecular Mechanisms of Intraocular Pressure Elevation....Pages 83-97
Glaucomatous Changes in the Trabecular Meshwork....Pages 99-116
Trabecular Mechanisms of Intraocular Pressure Elevation....Pages 117-138
Post-Trabecular Glaucomas with Elevated Episcleral Venous Pressure....Pages 139-157
Angle-Closure Glaucomas Anterior (Pulling) Mechanisms ....Pages 159-165
Angle-Closure Glaucomas....Pages 167-172
Angle-Closure Glaucomas....Pages 173-187
Front Matter....Pages 189-189
Genetics and Glaucoma Susceptibility....Pages 191-203
Myocilin Mutations and Their Role in Open-Angle Glaucoma....Pages 205-217
The Functional Role of Myocilin in Glaucoma....Pages 219-231
Roles of CYP1B1, Optineurin, and WDR36 Gene Mutations in Glaucoma....Pages 233-273
Genetic Association in the Open-Angle Glaucomas....Pages 275-288
ApoE Polymorphisms and Severity of Open-Angle Glaucoma....Pages 289-307
Front Matter....Pages 309-309
Changes in Aqueous Humor Dynamics with Age and Glaucoma....Pages 311-327
Mechanosensitive Genes in the Trabecular Meshwork at Homeostasis....Pages 329-362
Front Matter....Pages 309-309
Reactive Astrocytes in the Glaucomatous Optic Nerve Head....Pages 363-391
Optic Neuropathy and Ganglion Cell Degeneration in Glaucoma....Pages 393-423
Proteomics in Defining Pathogenic Processes Involved in Glaucomatous Neurodegeneration....Pages 425-441
Proteomic Advances Toward Understanding Mechanisms of Glaucoma Pathology....Pages 443-458
Molecular and Cellular Responses in the Eye to Glaucoma....Pages 459-467
Front Matter....Pages 469-469
Ocular Biomechanics in Glaucoma....Pages 471-489
Intraocular Pressure, Perfusion Pressure, and Optic Nerve Energy Metabolism....Pages 491-516
Optic Nerve....Pages 517-525
Psychophysiology of Glaucoma....Pages 527-548
Front Matter....Pages 549-549
The Primate Model of Experimental Glaucoma....Pages 551-577
Involvement of Inflammation in a Mouse Model of Inherited Pigmentary Glaucoma....Pages 579-600
Use of Purified Retinal Ganglion Cells for an In Vitro Model to Study Glaucoma....Pages 601-607
Front Matter....Pages 609-609
Pharmacological Therapies for Managing Glaucoma....Pages 611-644
Redox-Based Therapies for Neuroprotection....Pages 645-656
Neuroprotective Signaling Pathways in Glaucoma....Pages 657-681
Role of Selective Laser Trabeculoplasty in the Management of Glaucoma....Pages 683-691
Mechanisms and Mechanics of Incisional Surgery for Glaucoma....Pages 693-713
Aqueous Shunts....Pages 715-737
New Approaches to the Surgical Management of the Glaucomas....Pages 739-752
Back Matter....Pages 753-762
