Mechanisms of Oncogenesis: An update on Tumorigenesis

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This volume is part of a book series that was first published in 10-volumes by Kluwer in 1989 under the series editorship of Professor Hans E. Kaiser, D.Sc., former Professor of Pathology at the School of Medicine, University of Maryland at Baltimore, MD, USA along with other leaders in the field of Cancer. In order to encompass the growing body of knowledge on various aspects of cancer growth and progression since then, the series has now been expanded to 17 volumes.

This volume is a comprehensive update on the mechanisms of tumorigenesis, and includes the advances in the field, as provided by the use of the most recent molecular techniques (microarray, proteomic, and other omics). While the first portion of the book contains chapters discussing pediatric cancer, the influence of environmental factors and oncogene activity in tumorigenesis, the second portion of the book is structured by organ sites (Esophagus, Breast, Pancreas, Colon, Lung, Prostate, Skin, Brain, Endocrine System, Lymphoid System, Bone, Head and Neck, and Cervix). This format provides the reader with easy access to the needed information.

This definitive text will offer the medical professionals, whether in research, academia or clinical practice, the latest information endorsed by the world renowned contributors. The broad range of topics will make this a valued reference and provide a wealth of information, making this a "state of the science" on carcinogenesis.

Author(s): Alexander W. Kusnecov, Hymie Anisman (auth.), Domenico Coppola (eds.)
Series: Cancer Growth and Progression 12
Edition: 1
Publisher: Springer Netherlands
Year: 2010

Language: English
Pages: 314
Tags: Cancer Research; Oncology; Gene Expression; Microarrays; Gene Function

Front Matter....Pages i-xii
Cytokines and Stressors: Implications for Cancer Immunotherapy....Pages 1-18
The Role of Oncogene Activation in Tumor Progression....Pages 19-41
Carcinogenic Effects of Ionising Radiation....Pages 43-61
Chemical Carcinogenesis Role of Chloroform – Further Studies....Pages 63-69
Use of Organ Explant and Cell Culture in Cancer Research....Pages 71-87
Chromosomal Abnormalities in Selected Hematopoietic Malignancies Detected by Conventional and Molecular Cytogenetics: Diagnostic and Prognostic Significance....Pages 89-113
Mechanisms of Cancer Growth and Progression in Lymphoma....Pages 115-128
Pediatric Cancer Mechanisms of Cancer Growth and Progression....Pages 129-147
Carcinogenetic Pathway of Malignant Melanoma....Pages 149-157
Ewing Sarcoma: Molecular Characterization and Potential Molecular Therapeutic Targets....Pages 159-166
Molecular Mechanisms of Central Nervous System Metastasis....Pages 167-177
Carcinogenesis of Human Papillomavirus in Head and Neck Squamous Cell Carcinoma....Pages 179-186
Postmenopausal Hormone Replacement Therapy and Breast Cancer – Clinicopathologic Associations and Molecular Mechanisms....Pages 187-202
Carcinogenesis of Lung Cancer....Pages 203-212
Genesis of Barrett’s Neoplasia: Current Concepts....Pages 213-224
Genesis of Pancreatic Ductal Neoplasia....Pages 225-236
Recent Advances in the Pathogenesis of Pancreatic Endocrine Neoplasms....Pages 237-268
Mechanisms of Carcinogenesis in Colorectal Cancer....Pages 269-277
Carcinogenetic Pathway of Superficial Low-Grade Urothelial Carcinoma....Pages 279-284
Carcinogenetic Pathway of Urothelial Carcinoma....Pages 285-293
Mechanisms of Carcinogenesis in Prostate Cancer....Pages 295-304
HPV in Cervical Carcinoma....Pages 305-310
Back Matter....Pages 311-314