Maternal Mortality - Lessons Learnt from Autopsy

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The book discusses about 45 cases of maternal autopsies. These maternal mortalities are related to pregnancy-related diseases, pre-existing diseases that worsen or manifest during pregnancy and diseases for which pregnant patient has increased risk. As the study of maternal mortality is a healthcare quality indicator and plays an important role in the improvement of obstetric care, the book aims at discussing autopsy findings, which is the gold standard for establishing not only the causes of death, but also to uncover the various pathological lesions produced by the physiologic phenomenon of pregnancy. This helps in identifying the direct and indirect causes, which can be reviewed at multidisciplinary review meetings.

The chapters are arranged according to direct and indirect causes of maternal death, involving varied target organ systems i.e. central nervous system, cardiovascular system, respiratory system, gastro-intestinal tract, hepato-biliary system and pancreas, urinary system, female genital tract and others. However, it does not include diseases coincidental in pregnancy.

Each case begins with the complete case history (age, duration of pregnancy, clinical presentation, investigations, clinical diagnosis, therapy, and course during ward stay, if any), autopsy findings, followed by a clinico-pathological discussion and includes appropriate gross organ and microscopic images.

The book caters to the specialists in pathology, obstetrics, general medicine, critical care, surgery, pulmonologists, cardiology and all those involved in the care of pregnant women.

Author(s): Kusum D. Jashnani
Publisher: Springer
Year: 2022

Language: English
Pages: 226
City: Singapore

Preface
Contents
About the Editor
Part I: Direct Maternal Deaths
1: Catastrophic Abruptio Placentae: An Autopsy Case Series
1.1 Case Series
1.1.1 Case 1
1.1.2 Case 2
1.1.3 Case 3
1.2 Gross
1.2.1 Case 1
1.2.2 Case 2
1.2.3 Case 3
1.2.4 Final Cause of Death
1.3 Clinicopathologic Discussion
References
2: Liver Infarct in Pregnancy: A Complex, Rare and Dreadful Affair
2.1 Clinical History
2.2 Autopsy Findings
2.3 Final Cause of Death
2.4 Clinicopathologic Discussion
References
3: Cerebral Venous Sinus Thrombosis: An Avertable Catastrophe
3.1 Clinical History
3.2 Autopsy Findings
3.3 Final Cause of Death
3.4 Clinicopathologic Discussion
References
4: Fatty Liver: More Likely To Be Fatal in Pregnancy!
4.1 Clinical History
4.2 Autopsy Findings
4.3 Final Cause of Death
4.4 Clinicopathologic Discussion
References
5: Eclampsia: A Risk Factor for Intracranial Hemorrhage
5.1 Clinical History
5.2 Autopsy Findings
5.3 Final Cause of Death
5.4 Clinicopathologic Discussion
References
6: Cervical Trauma: Clinical Conundrum and Correlation
6.1 Case A
6.1.1 Clinical History
6.1.2 Autopsy Findings
6.1.3 Final Cause of Death
6.2 Case B
6.2.1 Clinical History
6.2.2 Autopsy Findings
6.2.3 Final Cause of Death
6.3 Clinicopathologic Discussion
References
7: Amniotic Fluid Embolism Syndrome: A Rare, Unpredictable, and Catastrophic Complication of Pregnancy
7.1 Clinical History
7.2 Autopsy Findings
7.3 Final Cause of Death
7.4 Clinicopathologic Correlation
References
8: Systemic Thromboembolism and Giant Gastric Mucormycotic Ulcer
8.1 Clinical History
8.2 Autopsy Findings
8.3 Final Cause of Death
8.4 Clinicopathologic Discussion
References
9: Puerperal Sepsis: A Preventable Cause of Maternal Death
9.1 Clinical History
9.2 Investigations
9.3 Autopsy Findings
9.4 Final Cause of Death
9.5 Clinicopathologic Discussion
References
10: Peripartum Cardiomyopathy: Failed Cardiac Physiology
10.1 Clinical History
10.2 Autopsy Findings
10.3 Final Cause of Death
10.4 Clinicopathologic Discussion
References
11: HELLP Syndrome: The Snowball Effect
11.1 Clinical History
11.2 Autopsy Findings
11.3 Final Cause of Death
11.4 Clinicopathologic Discussion
References
12: Uterine Anomalies: Less Common but Lethal if Not Detected!
12.1 Clinical History
12.2 Autopsy Findings
12.3 Final Cause of Death
12.4 Clinicopathologic Discussion
References
13: Retained Products of Conception and Dilatation and Curettage: A Cause for Disseminated Intravascular Coagulation
13.1 Clinical History
13.2 Autopsy Findings
13.3 Final Cause of Death
13.4 Clinicopathologic Correlation
References
Part II: Indirect Maternal Deaths
14: Pulmonary Bone Marrow Embolism: The Uncommon but Fatal Complication of Sickle Cell Disease
14.1 Clinical History
14.2 Investigations
14.3 Autopsy Findings
14.4 Final Cause of Death
14.5 Clinicopathologic Discussion
References
15: Neurocysticercosis, Pregnancy, and Albendazole: The Unholy Trio
15.1 Clinical History
15.2 Autopsy Findings
15.3 Final Cause of Death
15.4 Clinicopathologic Discussion
References
16: Lupus Nephritis and Pregnancy: Concern for Both Mother and Fetus
16.1 Clinical History
16.2 Autopsy Findings
16.3 Final Cause of Death
16.4 Clinicopathologic Discussion
References
17: Disseminated Microthrombi in Pregnancy: Not Always DIC, Think of TTP
17.1 Clinical History
17.2 Investigations
17.3 Autopsy Findings
17.4 Final Cause of Death
17.5 Clinicopathologic Discussion
References
18: HEV-Associated Hepatic Necrosis and Hepatic Encephalopathy in Pregnancy: Should Hepatitis E Virus Surveillance Be Made Mandatory in Pregnancy?
18.1 Clinical History
18.2 Autopsy Findings
18.3 Final Cause of Death
18.4 Clinicopathologic Discussion
References
19: H1N1 Influenza in Pregnancy: Yet Another Dreaded Flu
19.1 Clinical History
19.2 Autopsy Findings
19.3 Final Cause of Death
19.4 Clinicopathologic Discussion
References
20: “Über Diffuse” Myocarditis: Still a Giant Mystery!
20.1 Clinical History
20.2 Autopsy Findings
20.3 Final Cause of Death
20.4 Clinicopathologic Discussion
References
21: Liver: A Fatal Target of Sepsis-Related Organ Dysfunction
21.1 Clinical History
21.2 Investigations
21.3 Autopsy Findings
21.4 Final Cause of Death
21.5 Clinicopathologic Discussion
References
22: Complicated Malaria in Pregnancy
22.1 Clinical History
22.2 Autopsy Findings
22.3 Final Cause of Death
22.4 Clinicopathologic Discussion
References
23: Adrenal Hemorrhage: A Dark Horse in Maternal Mortality
23.1 Clinical History
23.2 Autopsy Findings
23.3 Final Cause of Death
23.4 Clinicopathologic Discussion
References
24: Disseminated Miliary Tuberculosis: A Classic Case of Fatality!
24.1 Clinical History
24.2 Autopsy Findings
24.3 Final Cause of Death
24.4 Clinicopathologic Discussion
References
25: Disseminated Miliary TB with Missing Millet Tubercles on Gross: Suspect Severe Immunocompromised State
25.1 Clinical History
25.1.1 Radiological Investigations
25.2 Autopsy Findings
25.2.1 Microscopy Findings
25.3 Final Cause of Death
25.4 Clinicopathologic Discussion
References
26: Mystic Hepatopathy in a Sickle Hemoglobinopathy
26.1 Clinical History
26.2 Autopsy Findings
26.3 Final Cause of Death
26.4 Clinicopathologic Discussion
References
27: Acute Hemorrhagic Pancreatitis and Sepsis: A Cause for Maternal Death
27.1 Clinical History
27.2 Autopsy Findings
27.3 Final Cause of Death
27.4 Clinicopathologic Discussion
References
28: Maternal Death Due to Non-Hodgkin’s Lymphoma
28.1 Clinical History
28.2 Autopsy Findings
28.3 Final Cause of Death
28.4 Clinicopathologic Discussion
References
29: Normal Physiologic Changes of Gravid Uterus
29.1 Case 1
29.1.1 Autopsy Findings
29.1.2 Microscopy
29.1.3 Final Cause of Death
29.2 Case 2
29.2.1 Autopsy Findings
29.2.2 Microscopy
29.2.3 Final Cause of Death
29.3 Clinicopathologic Discussion
References
30: Lobar Pneumonia: A Fatal Non-obstetric Infection!
30.1 Clinical History
30.2 Autopsy Findings
30.3 Final Cause of Death
30.4 Clinicopathologic Discussion
References
31: Uterine Arteriovenous Malformation
31.1 Clinical History
31.2 Autopsy Findings
31.3 Final Cause of Death
31.4 Clinicopathologic Discussion
References
32: Herpes Simplex Pneumonitis
32.1 Clinical History
32.2 Autopsy Findings
32.3 Final Cause of Death
32.4 Clinicopathologic Discussion
References
33: Renal Cortical Necrosis in Pregnancy: Still a Sad Reality in Developing Countries
33.1 Clinical History
33.2 Autopsy Findings
33.2.1 Gross Examination
33.2.2 Microscopy
33.3 Final Cause of Death
33.4 Clinicopathologic Discussion
33.5 Conclusion
References
34: Severe Anemia and Pregnancy
34.1 Clinical History
34.2 Autopsy Findings
34.3 Final Cause of Death
34.4 Clinicopathologic Discussion
References
35: Hypertrophic Cardiomyopathy as an Incidental Finding
35.1 Clinical History
35.2 Autopsy Findings
35.3 Final Cause of Death
35.4 Clinicopathologic Discussion
References
36: Gastrointestinal Candidiasis: An Unusual Accompaniment
36.1 Clinical History
36.2 Autopsy Findings
36.3 Final Cause of Death
36.4 Clinicopathologic Discussion
References
37: Plugging of Visceral Blood Vessels by Atypical Cells: Clue to Leukemia!
37.1 Clinical History
37.2 Autopsy Findings
37.3 Final Cause of Death
37.4 Clinicopathologic Discussion
References
38: Chronic Kidney Disease Masquerading as Pregnancy Induced Hypertension
38.1 Clinical History
38.2 Autopsy Findings
38.3 Final Cause of Death
38.4 Clinicopathologic Discussion
References
39: Pulmonary Edema and Aspiration Pneumonia: Cause for Maternal Death
39.1 Clinical History
39.2 Autopsy Findings
39.3 Final Cause of Death
39.4 Clinicopathologic Discussion
References
40: Postpartum Febrile Illness: Recurrent Acute Rheumatic Fever
40.1 Clinical History
40.2 Autopsy Findings
40.3 Final Cause of Death
40.4 Clinicopathologic Discussion
References
41: Common Atrioventricular Canal: A Fatality Due to a Commonality
41.1 Clinical History
41.2 Autopsy Findings
41.3 Final Cause of Death
41.4 Clinicopathologic Discussion
References
42: Choked Prosthetic Mitral Valve
42.1 Clinical History
42.2 Autopsy Findings
42.3 Final Cause of Death
42.4 Clinicopathologic Discussion
References
43: Interstitial Lung Disease: Scarred, Stiff Lungs with Honeycombing
43.1 Clinical History
43.2 Autopsy Findings
43.3 Final Cause of Death
43.4 Clinicopathologic Discussion
References
44: Diffuse Alveolar Damage in COVID-19 Infection
44.1 Clinical History
44.2 Autopsy Findings
44.3 Final Cause of Death
44.4 Clinicopathologic Discussion
References
45: Takayasu Arteritis: Third Trimester Tragedy
45.1 Clinical History
45.2 Autopsy Findings
45.3 Final Cause of Death
45.4 Clinicopathologic Discussion
References
Abbreviations