Selected as a Doody's Core Title for 2021!
Connect biochemistry to clinical practice!"
Marks’ Basic Medical Biochemistry links biochemistry to physiology and pathophysiology, allowing students to apply fundamental concepts to the practice of medicine – from diagnosing patients to recommending effective treatments. Intuitively organized chapters center on hypothetical patient vignettes, highlighting the material’s clinical applications; helpful icons allow for smooth navigation, making complex concepts easier to grasp.
Full-color illustrations make chemical structures and biochemical pathways easy to visualize.
Patient vignettes connect biochemistry to human health and disease.
Clinical Notes explain patient signs or symptoms, and Method Notes relate biochemistry to the laboratory tests ordered during diagnosis.Clinical Comments link biochemical dynamics to treatment options and patient outcomes.Biochemical Comments explore directions for new research.Key Concepts and Summary Disease tables highlight the take-home messages in each chapter.
Questions and answers at the end of each chapter – 470 total inside the book, with 560 more online – probe students’ mastery of key concepts.
Additional handy resources available online make it easy to review all diseases and all methods covered throughout the book and to find references for further information and study
Author(s): Michael Lieberman, Alisa Peet
Edition: 5
Publisher: LWW Wolters Kluwer
Year: 2017
Language: English
Commentary: TRUE PDF
Tags: Medical Biochemistry; Clinical biochemistry; Pathophysiology
Cover
Title
Copyright
Preface to the 5th Edition
How to Use This Book
Acknowledgments
Contents
SECTION I Fuel Metabolism
1 Metabolic Fuels and Dietary Components
2 The Fed or Absorptive State
3 Fasting
SECTION II Chemical and Biologic Foundations of Biochemistry
4 Water, Acids, Bases, and Buffers
5 Structures of the Major Compounds of the Body
6 Amino Acids in Proteins
7 Structure-Function Relationships in Proteins
8 Enzymes as Catalysts
9 Regulation of Enzymes
10 Relationship between Cell Biology and Biochemistry
11 Cell Signaling by Chemical Messengers
SECTION Ill Gene Expression and the Synthesis of Proteins
12 Structure of the Nucleic Acids
13 Synthesis of DNA
14 Transcription: Synthesis of RNA
15 Translation: Synthesis of Proteins
16 Regulation of Gene Expression
17 Use of Recombinant DNA Techniques in Medicine
18 The Molecular Biology of Cancer
SECTION IV Carbohydrate Metabolism, Fuel Oxidation, and the Generation of Adenosine Triphosphate
19 Basic Concepts in the Regulation of Fuel Metabolism by Insulin, Glucagon, and Other Hormones
20 Cellular Bioenergetics: Adenosine Triphosphate and O2
21 Digestion, Absorption, and Transport of Carbohydrates
22 Generation of Adenosine Triphosphate from Glucose, Fructose, and Galactose: Glycolysis
23 Tricarboxylic Acid Cycle
24 Oxidative Phosphorylation and Mitochondrial Function
25 Oxygen Toxicity and Free-Radical Injury
26 Formation and Degradation of Glycogen
27 Pentose Phosphate Pathway and the Synthesis of Glycosides, Lactose, Glycoproteins, and Glycolipids
28 Gluconeogenesis and Maintenance of Blood Glucose Levels
SECTION V Lipid Metabolism
29 Digestion and Transport of Dietary Lipids
30 Oxidation of Fatty Acids and Ketone Bodies
31 Synthesis of Fatty Acids, Triacylglycerols, and the Major Membrane Lipids
32 Cholesterol Absorption, Synthesis, Metabolism, and Fate
33 Metabolism of Ethanol
34 Integration of Carbohydrate and Lipid Metabolism
SECTION VI Nitrogen Metabolism
35 Protein Digestion and Amino Acid Absorption
36 Fate of Amino Acid Nitrogen: Urea Cycle
37 Synthesis and Degradation of Amino Acids
38 Tetrahydrofolate,Vitamin B12, and S-Adenosylmethionine
39 Purine and Pyrimidine Metabolism
40 lntertissue Relationships in the Metabolism of Amino Acids
SECTION VII Tissue Metabolism
41 Actions of Hormones that Regulate Fuel Metabolism
42 The Biochemistry of Erythrocytes and Other Blood Cells
43 Blood Plasma Proteins, Coagulation, and Fibrinolysis
44 Liver Metabolism
45 Metabolism of Muscle at Rest and during Exercise
46 Metabolism of the Nervous System
47 The Extracellular Matrix and Connective Tissue
Patient Index
Subject Index
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