This comprehensive resource provides authoritative knowledge of the most up-to-date prevention and treatment strategies for thoracic malignancies. Established and investigational therapies are placed in the context of tumor biology for a full understanding of the pharmacogenetics, etiology, and changing epidemiology of lung cancer. Expert clinicians detail the function of predictive and prognostic factors in the utilization of chemo-radiotherapy, adjuvant and neoadjuvant treatment, and targeted agents. The promises and potential pitfalls of investigational strategies are evaluated with exceptional insight and clarity, with unique attention paid to the mechanisms of drug resistance and targets for lung cancer treatment and prevention. Lung Cancer: Prevention, Management, and Emerging Therapies engages the entire spectrum of therapeutic modalities with focus on systemic approaches. Disease coverage includes newly diagnosed and recurrent non-small cell lung cancer, small cell carcinoma, and mesothelioma. Critical examination of the impact, methodology, and design of clinical trials is presented along with new paradigms for personalized approaches and individual risk assessment.
Author(s): Alejandro Corvalan, Ignacio I. Wistuba (auth.), David J. Stewart (eds.)
Series: Current Clinical Oncology
Edition: 1
Publisher: Humana Press
Year: 2010
Language: English
Pages: 538
Tags: Oncology; Pneumology/Respiratory System; Radiotherapy; Medical Biochemistry
Front Matter....Pages i-xvi
Molecular Pathology of Lung Cancer....Pages 1-25
Tumor Microenvironment....Pages 27-69
Racial and Ethnic Diversity in Lung Cancer....Pages 71-85
Pharmacogenetics of Lung Cancer....Pages 87-106
Lung Cancer Prevention....Pages 107-138
Adjuvant and Neoadjuvant Therapy of NSCLC....Pages 139-159
Chemoradiotherapy for Inoperable Non-small Cell Lung Cancer....Pages 161-175
Management of Advanced Non-small Cell Lung Cancer: Front Line Treatment....Pages 177-194
Chemotherapy in Previously Treated Patients with Non-small Cell Lung Cancer....Pages 195-204
Epidermal Growth Factor Receptor Inhibitors in the Treatment of Non-small Cell Lung Cancer....Pages 205-226
Angiogenesis Inhibitors in Lung Cancer....Pages 227-252
Other Molecular Targeted Agents in Non-small Cell Lung Cancer....Pages 253-278
Vaccine Therapy for Lung Cancer....Pages 279-303
Gene-Based Therapies for Lung Cancer....Pages 305-330
Lung Cancer Resistance to Chemotherapy....Pages 331-393
Small Cell Carcinoma of the Lung....Pages 395-434
Mesothelioma....Pages 435-465
Advances in Oncology Clinical Research: Statistical and Study Design Methodologies....Pages 467-481
Palliative Care for Patients with Lung Cancer....Pages 483-502
The Future of Lung Cancer....Pages 503-514
Back Matter....Pages 515-538
