This book provides a comprehensive overview of the localized drug delivery system landscape. The 10 chapters provide a detailed introduction in polymers, nanostructures and nanocomposites for developing localized controlled drug delivery systems (LCDDSs) in the form of stimuli-responsive delivery systems, targeted drug delivery systems or the combination of both. A discussion on manufacturing techniques, optimization, challenges and adaptation of LCDDSs for the treatment of a wide range of diseases is also included.
This simple and informative resource conveys an understanding about designing novel drug delivery systems to students in advanced pharmacology, biotechnology, materials science and biochemistry study programs. Readers will be equipped with the knowledge of regulating drug release rates to get a desired pharmacological profile, that helps a researcher to ensure a high therapeutic effectiveness.
The detailed information about various drug delivery systems and a compilation of recent literature sources also paves the way for research scholars to construct a drug targeting framework for their research plans.
Author(s): Seyed Morteza Naghib, Samin Hoseinpour, Shadi Zarshad
Publisher: Bentham Science Publishers
Year: 2022
Language: English
Pages: 265
City: Singapore
Cover
Title
Copyright
End User License Agreement
Contents
Preface
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
Introduction to Localized Controlled Drug Delivery Systems (LCDDSs)
1.1. HISTORY AND STATISTICAL TRENDS IN LCDDS
1.2. SCIENTIFIC AND TECHNOLOGICAL IMPACT OF LCDDS
1.3. CHALLENGES IN LOCALIZED STIMULI RESPONSIVE MATERIALS
CONCLUSION
REFERENCES
Carbon Nanostructures in Localized Controlled Drug Delivery Systems (LCDDSs)
2.1. INTRODUCTION
2.2. GRAPHENE
2.3. GRAPHENE OXIDE (GO)
2.4. REDUCED GRAPHENE OXIDE (RGO)
2.5. ENDOGENOUS STIMULI-RESPONSIVE LOCALIZED DRUG DELIVERY WITH GRAPHENE
2.5.1. pH-responsive Localized Drug Delivery With Graphene
2.5.2. Redox-responsive Localized Drug Delivery with Graphene
2.6. GRAPHENE-BASED DRUG DELIVERY SYSTEMS RESPONSIVE TO EXTERNAL PHYSICAL STIMULI
2.6.1. Light-responsive Drug Delivery Systems with Graphene
2.6.2. Temperature-responsive Drug Delivery Systems with Graphene
2.7. TOXICITY AND BIOCOMPATIBILITY OF GRAPHENE MATERIALS
2.8. CARBON NANOTUBE (CNT)
2.8.1. Multi-Wall Carbon Nanotube (MWCNT)
2.8.2. Single Wall Carbon Nanotube (SWCNT)
2.9. FULLERENE
2.10. OTHER CARBON NANOSTRUCTURES:
2.11. BLACK PHOSPHORUS (BP)
CONCLUSION
REFERENCES
Polymers in Localized Controlled Drug Delivery Systems (LCDDSs)
3.1. INTRODUCTION
3.2. SYNTHETIC POLYMERS
3.2.1. Polyesters
3.2.1.1. Polylactic Acid (PLA) and Polyglycolic Acid (PGA)
3.2.1.2. Poly Lactic-co-glycolic Acid (PLGA)
3.2.1.3. Polycaprolactones (PCL)
3.2.1.4. Poly(Alkyl Cyanoacrylates) (PACA)
3.2.3. Poly(Ortho Esters)
3.2.4. Poly(Anhydrides)
3.2.5. Poly(amides)
3.2.6. Poly(Ester Amides)
3.2.7. Poly(Phosphoesters)
3.3. NATURALLY-DERIVED POLYMERS
3.3.1. Polysaccharides-Based Polymers
3.3.1.1. Chitosan
3.3.1.2. Hyaluronic Acid-based Polymers
3.3.2. Polypeptides-Based Polymers
3.3.2.1. Collagen-based Polymers & Gelatin-based Polymers
CONCLUSION
REFERENCES
Carbon Nanostructure/polymer Composites Processing and Characteristics in Localized Controlled Drug Delivery System (LCDDSs)
4.1. INTRODUCTION
4.2. MICROSTRUCTURES
4.3. GLASS TRANSITION OF POLYMER MATRIX
4.4. HYDROPHOBICITY AND HYDROPHILICITY OF COMPOSITES
4.5. MOLECULAR WEIGHT OF POLYMER MATRIX
CONCLUSION
REFERENCES
Composites in Localized Controlled Drug Delivery Systems (LCDDSs)
5.1. INTRODUCTION
5.2. MICROSCALED COMPOSITES IN DDS
5.3. NANOSCALED COMPOSITES IN DDS
5.4. THE EPR EFFECT
5.5. FABRICATION METHODS OF MICRO/NANOSCALED COMPOSITES
5.5.1. Emulsification-solvent Evaporation
5.5.2. Spray Drying
5.5.3. Electrospraying
5.5.4. Supercritical Fluids Processing (SCF)
5.5.4.1. The Supercritical Anti-Solvent (SAS) Technique
5.5.4.2. Supercritical CO2 Foaming (SF)
5.5.5. Microfluidics
5.5.6. ProLease Technique
5.5.7. Nanoprecipitation/Solvent Displacement
5.5.8. Emulsion Techniques
CONCLUSION
REFERENCES
Exogeneous-triggered Delivery in Localized Controlled Drug Delivery Systems (LCDDSs)
6.1. INTRODUCTION
6.2. THERMO-RESPONSIVE DRUG RELEASE
6.2.1. Poly(N-isopropylacrylamide) vs poly(Nvinylcaprolactam)-based Composites
6.2.2. Oligoethylene Glycol-based Composites
6.2.3. Degradable Composites
6.3. LIGHT-RESPONSIVE DRUG DELIVERY
6.3.1. UV-light-responsive Drug Delivery
6.3.2. NIR-light-responsive Drug Delivery
6.4. ULTRASOUND-RESPONSIVE DRUG DELIVERY
CONCLUSION
REFERENCES
Endogenous-triggered Delivery in Localized Controlled Drug Delivery Systems (LCDDSs)
7.1. INTRODUCTION
7.2. REDOX-SENSITIVE DRUG DELIVERY
7.3. OXIDATION-SENSITIVE DRUG DELIVERY
7.4. PH-SENSITIVE DRUG DELIVERY
7.5. ENZYME-SENSITIVE DRUG DELIVERY
CONCLUSION
REFERENCES
Nanoparticles-mediated Localized Controlled Drug Delivery Systems (LCDDSs)
8.1. INTRODUCTION
8.2. GOLD NANOPARTICLES IN TRIGGERED DRUG DELIVERY
8.3. MAGNETIC NANOPARTICLES IN TRIGGERED DRUG DELIVERY
8.4. CALCIUM PHOSPHATE-BASED NANOPARTICLES IN TRIGGERED DRUG DELIVERY
8.5. MESOPOROUS SILICA
CONCLUSION
REFERENCES
Additive Manufacturing in Developing Localized Controlled Drug Delivery Systems (LCDDSs)
9.1. INTRODUCTION
9.2. 3D PRINTING METHODS
9.3 THE ROLE OF 3D PRINTING IN DEVELOPING AND FABRICATING DDSS
9.4. FROM 3D PRINTING TO 4D PRINTING
9.5. DESIGNING IN 4D PRINTING
CONCLUSION
REFERENCES
Conclusion and Future Outlooks
REFERENCES
Subject Index
