Liver Immunology: Principles and Practice

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Immunology is a broad branch of biomedical science that covers the study of all aspects of the immune system in all organisms. It deals with, among other things, the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, allograft rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo. Immunology has various applications in several disciplines of science, and as such is further divided.

Liver Immunology: Principles and Practice covers bacterial, parasitic and viral infections of the liver, autoimmune liver disease, alcoholic and nonalcoholic fatty liver diseases, and transplantation in an easy-to-read and thorough format. Authors also address the key issues that have arisen in this field in recent years, including physiological roles of hepatocytes, sinusoidal lining cells, activated macrophages (Kupffer cells), cholangiocytes and stellate cells, and their modulation of T cells, natural killer (NK) cells and NKT cells. This volume will become a must-read for clinicians, investigators and students, novice and expert alike.

Author(s): M. Eric Gershwin, John M. Vierling, Michael P. Manns
Edition: 1
Publisher: Humana Press
Year: 2007

Language: English
Commentary: 2777
Pages: 468

C.pdf......Page 1
front-matter.pdf......Page 2
01 Contemporary Liver Immunology and Immunopathology.pdf......Page 13
Part I.pdf......Page 24
1.01 A Short Primer on Fundamental Immunology.pdf......Page 25
1.02 Role and Function of Liver Sinusoidal Endothelial Cells.pdf......Page 35
1.03 Innate Immune Mechanisms in the Liver.pdf......Page 50
1.04 Antigen Processing and Presentation in the Liver.pdf......Page 58
1.05 Adaptive Immunity in the Liver.pdf......Page 69
1.06 Hepatic NK, NKT, and T Cells.pdf......Page 79
1.07 Cytokines in Liver Health and Disease.pdf......Page 91
1.08 Prevalence and Significance of Autoantibodies in Acute and Chronic Liver Diseases and Hepatocellular Carcinoma.pdf......Page 102
1.09 The Role of Inflammation and Immunity in the Pathogenesis of Liver Fibrosis.pdf......Page 118
1.10 Clinical Use of Immunopathology Techniques in Liver Diseases.pdf......Page 129
1.11 Tumor Immunology.pdf......Page 143
Part II.pdf......Page 156
2.12 Innate and Adaptive Immune Responses to Bacterial and Parasite Infections.pdf......Page 157
2.13 Immune Response to Hepatitis A and E Viruses.pdf......Page 167
2.14 Role of the Immune Response in Hepatitis B.pdf......Page 182
2.15 Immune Responses in Acute and Chronic Hepatitis C.pdf......Page 195
2.16 Immunopathogenesis of Extrahepatic Manifestations in HAV, HBV, and HCV Infections.pdf......Page 211
Part III.pdf......Page 220
3.17 Immunogenetics of Autoimmune Liver Disease.pdf......Page 221
3.18 Primary Biliary Cirrhosis and Autoimmune Cholangitis.pdf......Page 234
3.19 Sclerosing Cholangitis.pdf......Page 247
3.20 Autoimmune Hepatitis.pdf......Page 260
3.21 Unique Aspects of Autoimmune Hepatitis in Children.pdf......Page 273
3.22 Overlap Syndromes of Autoimmune Hepatitis With Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis.pdf......Page 280
3.23 Animal Models of Autoimmune Liver Diseases.pdf......Page 287
Part IV.pdf......Page 301
4.24 The Immune Response in the Pathogenesis of Alcoholic Liver Disease.pdf......Page 302
4.25 Immunomodulation Therapy for Alcoholic Hepatitis.pdf......Page 315
4.26 Role of Immune Response in Nonalcoholic Fatty Liver Disease.pdf......Page 329
Part V.pdf......Page 338
5.27 Mechanisms of Acute Liver Failure.pdf......Page 339
Part VI.pdf......Page 350
6.28 Immune Mechanisms in Drug-Induced Hepatotoxicity.pdf......Page 351
6.29 Acute and Chronic Liver Diseases Induced by Drugs or Xenobiotics.pdf......Page 363
Part VII.pdf......Page 377
7.30 Clinical Use of Immunosuppressive Drugs to Control the Immune Response.pdf......Page 378
7.31 Hepatic Complications of Hematopoietic Cell Transplantation.pdf......Page 395
7.32 Acute and Chronic Rejection of the Liver Allograft.pdf......Page 408
7.34 Autoimmune Diseases in Transplanted Livers.pdf......Page 417
7.33 Immunological Tolerance in Allo- and Xenografts.pdf......Page 424
7.35 Immunopathogenesis and Outcomes of Recurrent Hepatitis C.pdf......Page 441
back-matter.pdf......Page 453