The concept of leukocyte depletion has been acknowledged as a mandatory procedure in transfusion medicine for a while. Within recent years, leukocyte removal filters have also become a more and more important tool in cardiac surgery, where this procedure is a logical strategy to limit neutrophil-mediated disorders. The complex biology of neutrophils therefore represents a major point of interest of this volume. Different clinical settings and the corresponding leukocyte filtration methods are a further topic of discussion, including transfusion, transplantation, perfusion and filtration modalities, blood cardioplegia as well as future filtration strategies such as bioactive cytokine filters. Aiming to provide an overview of the experience with experimental and clinical leukocyte filtration and of the state-of-the-art in clinical application, this book also gives an outlook on the possible future role of leukocyte depletion in cardiac surgery and cardiology.
Author(s): Georg Matheis, Anton Moritz, Martin Scholz
Edition: 1
Publisher: S. Karger AG (Switzerland)
Year: 2001
Language: English
Pages: 158
NIK......Page 1
Preliminary Pages.pdf......Page 2
01 Leukocyte Biology and Pathogenicity in Cardiac Surgery and Cardiology- The Need for Leukocyte Depletion.pdf......Page 10
02 Leukocyte-Mediated Cerebral Disorders during and after Cardiac Surgery.pdf......Page 22
03 Mechanisms and Technical Aspects of Leukocyte Depletion.pdf......Page 25
04 Transfusion- Pathology and Relevance of Leukocyte Reduction.pdf......Page 42
05 Immunopathogenicity in Heart, Heart-Lung Transplantation- Relevance of Leukocyte Depletion.pdf......Page 53
06 Pathogenicity of Cardiopulmonary Bypass and Concepts of Leukocyte Filtration.pdf......Page 56
07 Reperfusion Injury during Cardiopulmonary Bypass.pdf......Page 63
08 Mechanism and Strategy of Leukocyte Depletion during Cardiopulmonary Bypass Surgery.pdf......Page 87
09 Leukocyte Filters in Perfusion.pdf......Page 98
10 Strategic Leukocyte Filtration- Clinical and Experimental Experience.pdf......Page 110
11 Hypoxia, Reoxygenation, and the Role of Leukodepletion in the Intraoperative Management of Congenital Heart Disease.pdf......Page 120
12 Blood Cardioplegia and Reperfusion.pdf......Page 144
13 Future Perspectives to Limit the Pathogenicity of Leukocytes in Cardiac Surgery and Cardiology.pdf......Page 156
Author Index.pdf......Page 163
Subject Index.pdf......Page 164
