Kucers' The Use of Antibiotics is the definitive, internationally-authored reference, providing everything that the infectious diseases specialist and prescriber needs to know about antimicrobials in this vast and rapidly developing field. The much-expanded Seventh Edition comprises 4800 pages in 3 volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into four sections - antibiotics, anti-fungal drugs, anti-parasitic drugs, and anti-viral drugs - and is highly structured for ease of reference.
Each chapter is organized in a consistent format, covering susceptibility, formulations and dosing (adult and pediatric), pharmacokinetics and pharmacodynamics, toxicity, and drug distribution, with detailed discussion regarding clinical uses - a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with expert contributors representing Europe, Africa, Asia, Australia, South America, the US, and Canada, the Seventh Edition adopts a truly global approach. It remains invaluable for anyone using antimicrobial agents in their clinical practice and provides, in a systematic and concise manner, all the information required when prescribing an antimicrobial to treat infection.
Author(s): M. Lindsay Grayson, Sara E. Cosgrove, Suzanne M. Crowe, M. Lindsay Grayson, William Hope, James S. McCarthy, John Mills, Johan W. Mouton, David L. Paterson
Edition: 7
Publisher: CRC Press
Year: 2017
Language: English
Pages: 5390
Tags: Antibiotics, Antimicrobials, Infectious Diseases, Pharmacology
Cover
Half Title
Title Page
Copyright Page
Table of Contents
Contributors
Foreword to the 7th Edition
Foreword to the 6th Edition
Obituary: Dr. Alvis Kucers
Hail the Greats
Preface
Abbreviations
VOLUME 1
Section 1: INTRODUCTION
1: Principles of Antimicrobial Use
2: Use of Critically Important Antimicrobials in Food Production
Section 2: ANTIBIOTICS
Part 2:1: PENICILLINS AND RELATED DRUGS
3: Benzylpenicillin (Penicillin G)
4: Phenoxypenicillins
5: Ampicillin and Amoxicillin
6: Methicillin
7: Isoxazolyl Penicillins: Oxacillin, Cloxacillin, Dicloxacillin, and Flucloxacillin
8: Nafcillin
9: Carbenicillin, Carindacillin, Carfecillin, and Ticarcillin
10: Mezlocillin, Azlocillin, Apalcillin, and Piperacillin
11: Mecillinam (Amdinocillin) and Pivmecillinam
12: Temocillin
13: Beta-Lactamase Inhibitors
14: Amoxicillin–Clavulanic Acid
15: Ampicillin–Sulbactam
16: Ticarcillin–Clavulanic Acid
17: Piperacillin–Tazobactam
Part 2:2: CEPHALOSPORINS AND RELATED DRUGS
18: Cephalothin and Cefazolin
19: Cephalexin
20: Cephadroxil, Cephaloridine, Cephacetrile, Cephapirin, Cephradine, and Other Rarely Used First-Generation Cephalosporins
21: Cefaclor, Cefprozil, and Loracarbef
22: Cefuroxime
23: Cefotiam, Cefuzonam, Cefamandole, Cefonicid, and Ceforanide
24: Cefoxitin, Cefotetan, and Other Cephamycins
25: Cefoperazone and Cefoperazone–Sulbactam
26: Cefotaxime
27: Ceftriaxone
28: Ceftizoxime, Cefdinir, Cefditoren, Cefpodoxime, Ceftibuten, Cefsulodin, and Cefpiramide
29: Cefixime
30: Ceftazidime and Ceftazidime–Avibactam
31: Cefepime, Cefpirome, and Cefepime–Tazobactam
32: Ceftaroline and Ceftaroline–Avibactam
33: Ceftobiprole
34: Ceftolozane–Tazobactam
35: Aztreonam and Aztreonam–Avibactam
36: Cefiderocol (S-649266)
Part 2:3: CARBAPENEMS
37: Imipenem–Cilastatin and Imipenem–Relebactam
38: Meropenem and Meropenem–Vaborbactam
39: Doripenem
40: Ertapenem
41: Faropenem
42: Biapenem, Ritipenem, Panipenem, and Sulopenem
Part 2:4: GLYCOPEPTIDES AND LIPOPEPTIDES
43: Vancomycin
44: Teicoplanin
45: Daptomycin
46: Oritavancin
47: Dalbavancin
48: Telavancin
49: Ramoplanin
50: Surotomycin
Part 2:5: AMINOGLYCOSIDES
51: Kanamycin
52: Gentamicin
53: Tobramycin
54: Amikacin
55: Sisomicin and Netilmicin
56: Isepamicin
57: Neomycin
58: Plazomicin
Part 2:6: MACROLIDES AND KETOLIDES
59: Erythromycin
60: Roxithromycin
61: Clarithromycin
62: Azithromycin
63: Josamycin and Rosaramicin
64: Telithromycin
65: Cethromycin
66: Solithromycin
Part 2:7: TETRACYCLINES AND RELATED DRUGS
67: Tetracycline
68: Doxycycline
69: Minocycline
70: Tigecycline
71: Omadacycline
72: Eravacycline
Part 2:8: OTHER ANTIBIOTICS
73: Linezolid
74: Cadazolid
75: Radezolid
76: Tedizolid
77: Quinupristin–Dalfopristin
78: Pristinamycin
79: Fosfomycin
80: Fusidate Sodium
81: Polymyxins
82: Novobiocin
83: Bacitracin and Gramicidin
84: Mupirocin
85: Clindamycin and Lincomycin
86: Chloramphenicol and Thiamphenicol
87: Spectinomycin
88: Fidaxomicin
89: Lefamulin
90: Retapamulin
VOLUME 2
Part 2:9: ANTIFOLATE AGENTS AND OTHER SYNTHETIC ANTIBACTERIALS
91: Sulfonamides
92: Trimethoprim and Trimethoprim–Sulfamethoxazole (Cotrimoxazole)
93: Pyrimethamine
94: Dapsone
95: Trimetrexate
96: Iclaprim
97: Nitrofurans: Nitrofurazone, Furazidine, and Nitrofurantoin
98: Methenamine Mandelate and Methenamine Hippurate
Part 2:10: NITROIMIDAZOLES
99: Metronidazole
100: Tinidazole
Part 2:11: QUINOLONES AND FLUOROQUINOLONES
2:11A: NEW AND COMMONLY USED FLUOROQUINOLONES
101: Ciprofloxacin
102: Norfloxacin
103: Ofloxacin
104: Levofloxacin
105: Moxifloxacin
106: Gemifloxacin
107: Sitafloxacin
108: Delafloxacin
109: Finafloxacin
110: Prulifloxacin/Ulifloxacin
111: Avarofloxacin, Nemonoxacin, and Zabofloxacin
2:11B: OLDER, RARELY USED QUINOLONES AND FLUOROQUINOLONES
112: Enoxacin
113: Fleroxacin
114: Garenoxacin
115: Gatifloxacin
116: Lomefloxacin
117: Nalidixic Acid and Other Quinolones
118: Pefloxacin
119: Rufloxacin
120: Sparfloxacin
121: Tosufloxacin
122: Discontinued Fluoroquinolones
Part 2:12: ANTI-TUBERCULOUS DRUGS
123: Isoniazid
124: Ethambutol
125: Pyrazinamide
126: Rifampicin (Rifampin)
127: Rifabutin
128: Rifaximin
129: Rifapentine
130: Streptomycin
131: para-Aminosalicylic Acid (PAS)
132: Ethionamide and Prothionamide
133: Thiacetazone
134: Capreomycin
135: Cycloserine and Terizidone
136: Viomycin
137: Clofazimine
138: Bedaquiline
139: Delamanid and Pretomanid
140: Sutezolid
Section 3: ANTIFUNGAL DRUGS
Part 3:1: POLYENES
141: Amphotericin B Deoxycholate
142: Liposomal Amphotericin B
143: Amphotericin B Lipid Complex (ABLC)
144: Nystatin
145: Natamycin
Part 3:2: ECHINOCANDINS
146: Caspofungin
147: Micafungin
148: Anidulafungin
Part 3:3: ALLYLAMINES AND BENZYLAMINE DERIVATIVES
149: Terbinafine
150: Butenafine
151: Naftifine
Part 3:4: SYSTEMIC AZOLES
152: Ketoconazole
153: Fluconazole
154: Itraconazole
155: Miconazole
156: Voriconazole
157: Posaconazole
158: Isavuconazole
159: Albaconazole
160: Ravuconazole
Part 3:5: TOPICAL AZOLES
161: Topical Azoles
Part 3:6: TOPICAL AGENTS—THIOCARBOMATES, HYDROXYPYRIDONES, AND MORPHOLINE
162: Tolnaftate
163: Amorolfine
164: Ciclopirox
165: Rilopirox
Part 3:7: OTHER ANTIFUNGAL AGENTS
166: Flucytosine (5-Fluorocytosine; 5-FC)
167: Griseofulvin
168: Haloprogin
VOLUME 3
Section 4: ANTIPARASITIC DRUGS
Part 4:1: ANTI-MALARIAL DRUGS
169: Artemisinins
170: Artesunate
171: Artemether–Lumefantrine
172: Dihydroartemisinin–Piperaquine
173: Pyronaridine–Artesunate
174: Artemisinin–Naphthoquine
175: Chloroquine and Hydroxychloroquine
176: Amodiaquine
177: Quinine and Quinidine
178: Mefloquine
179: Halofantrine
180: Primaquine
181: Tafenoquine
182: Atovaquone
183: Proguanil and Chlorproguanil
184: Atovaquone–Proguanil
Part 4:2: AGENTS ACTIVE AGAINST INTESTINAL AND EXTRA-INTESTINAL PROTOZOA
185: Paromomycin
186: Nitazoxanide
187: Spiramycin
188: Fumagillin
189: Furazolidone (Furazolidine)
190: Diloxanide Furoate
191: Iodoquinol and Quinacrine
Part 4:3: AGENTS ACTIVE AGAINST AMERICAN TRYPANOSOMIASIS
192: Benznidazole
193: Nifurtimox
Part 4:4: AGENTS ACTIVE AGAINST AFRICAN TRYPANOSOMIASIS
194: Suramin
195: Melarsoprol
196: Eflornithine
Part 4:5: AGENTS ACTIVE AGAINST LEISHMANIA AND OTHER PATHOGENS
197: Pentamidine
198: Antimonial Agents
199: Miltefosine
Part 4:6: AGENTS ACTIVE AGAINST HELMINTHS
200: Albendazole
201: Mebendazole
202: Thiabendazole and Flubendazole
203: Triclabendazole
204: Ivermectin and Moxidectin
205: Diethylcarbamazine
206: Pyrantel and Oxantel Pamoate
207: Praziquantel
208: Oxamniquine and Metrifonate
209: Niclosamide
Part 4:7: AGENTS ACTIVE AGAINST ECTOPARASITES
210: Permethrin
211: Lindane and Malathion
212: Crotamiton
Section 5: ANTIVIRAL DRUGS
Part 5:1: AGENTS ACTIVE AGAINST HERPESVIRUSES
213: Aciclovir and Valaciclovir
214: Famciclovir and Penciclovir
215: Ganciclovir and Valganciclovir
216: Cidofovir and Brincidofovir
217: Brivudin
218: Discontinued Herpesvirus Agent: Vidarabine
219: Foscarnet
220: Letermovir
221: Trifluridine (Trifluorothymidine)
222: Idoxuridine
223: Maribavir
224: Fomivirsen
Part 5:2: AGENTS ACTIVE AGAINST THE HUMAN IMMUNODEFICIENCY VIRUS
5:2A: NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
225: Zidovudine
226: Didanosine
227: Zalcitabine
228: Lamivudine
229: Stavudine
230: Abacavir
231: Emtricitabine
232: Tenofovir
233: Amdoxovir
234: Apricitabine
5:2B: NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
235: Nevirapine
236: Efavirenz
237: Delavirdine
238: Etravirine
239: Rilpivirine
5:2C: INHIBITORS OF HIV PROTEASE
240: Saquinavir
241: Indinavir
242: Nelfinavir
243: Lopinavir
244: Fosamprenavir
245: Darunavir
246: Atazanavir
247: Tipranavir
248: Ritonavir and Cobicistat
5:2D: INTEGRASE INHIBITORS
249: Raltegravir
250: Elvitegravir
251: Dolutegravir
5:2E: OTHER ANTI-HIV AGENTS
252: Enfuvirtide
253: Maraviroc
Part 5:3: AGENTS ACTIVE AGAINST HEPATITIS VIRUSES
254: Entecavir
255: Adefovir Dipivoxil
256: Telbivudine
257: Discontinued Hepatitis Agents: Torcitabine and Valtorcitabine
258: Discontinued Hepatitis Agent: Clevudine
259: Ribavirin
260: Interferon Alpha
261: Protease, Polymerase and Assembly Inhibitors for the Treatment of Hepatitis C Virus Infection
262: Sofosbuvir Combined with Ledipasvir, Daclatasvir, or Other Drugs
263: Ombitasvir Combined with Paritaprevir, Dasabuvir, or Other Drugs
264: Grazoprevir Combined with Elbasvir or Other Drugs
PART 5:4: AGENTS ACTIVE AGAINST INFLUENZA VIRUSES
265: Amantadine and Rimantadine
266: Zanamivir, Laninamivir, and Polyvalent Zanamivir Conjugates
267: Oseltamivir
268: Peramivir
PART 5:5: INVESTIGATIONAL ANTIVIRAL DRUGS
269: Investigational Antiviral Drugs
Index
