Offering details on the pharmacology of itch, techniques of itch evaluation, and neurogenic itch, this reference presents new concepts in the neurophysiology and central mechanisms of itch, animal models of itch, and processing of histamine itch in the human cerebral cortex. The text clarifies itch in systemic and skin disease, exploring renal itch, uremic pruritus, lichen amyloidosis and more.
Author(s): Gil Yosipovitch, Malcolm W. Greaves, Jr., Alan B. Fleischer, Francis McGlone
Edition: 1
Year: 2003
Language: English
Pages: 342
Cover......Page 1
Series Introduction......Page 7
Foreword......Page 8
Preface......Page 10
Contents......Page 12
Contributors......Page 16
1. Definitions of Itch......Page 21
2. Neurophysiologic Basis of Itch......Page 25
3. Pain and Itch......Page 33
4. Central Neural Mechanisms of Itch......Page 41
5. Animal Models of Itch: Scratching Away at the Problem......Page 55
6. Histamine-Induced Discriminative and Affective Responses Revealed by Functional MRI......Page 71
7. Central Nervous System Imaging of Itch with PET......Page 82
8. Skin Nerve Anatomy: Neuropeptide Distribution and Its Relationship to Itch......Page 90
9. Substance P and Itch......Page 106
10. Peripheral Opiate Receptor System in Human Epidermis and Itch......Page 115
11. Antipruritic Activity of a Novel K-Opioid Receptor Agonist, TRK-820......Page 128
12. Putative Role of Cannabinoids in Experimentally Induced Itch and Inflammation in Human Skin......Page 136
13. Itch Models in Animals, with Special Emphasis on the Serotonin Model in Rats......Page 152
14. Human Itch Models, with Special Emphasis on Itch in SLS-Inflamed and Normal Skin......Page 160
15. Microdialysis in Itch Research......Page 167
16. Measuring Nocturnal Scratching in Atopic Dermatitits......Page 181
17. Itch Questionnaires as Tools for Itch Evaluation......Page 188
18. Epidemiology of Itching in Skin and Systemic Diseases......Page 202
19. Uremic Pruritus: New Perspectives and Insights from Recent Trials......Page 211
20. Pruritus Complicating Liver Disease......Page 222
21. Itch in HIV-Infected Patients......Page 236
22. Neuropathic Pruritus......Page 247
23. Clinical Features of Itch in Atopic Eczema......Page 256
24. Postburn Itch......Page 262
25. Pruritus in Lichen Simplex Chronicus and Lichen Amyloidosis......Page 269
26. Treatment of Pruritus in Internal and Dermatological Diseases with Opioid Receptor Antagonists......Page 273
27. Prospects for a Novel K-Opioid Receptor Agonist, TRK-820, in Uremic Pruritus......Page 292
28. Treatment of Pruritic Skin Diseases with Topical Capsaicin......Page 300
29. Mechanistic and Clinical Assessment of ZangradoR, an Extract of the Amazonian Ethnomedicine Sangre de Grado, for the Treatment of Itch......Page 318
30. Reduction in Itch Severity with Topical Immunomodulators: A New Approach for Patients with Inflammatory Disease......Page 328
31. 5-HT3 Receptor Antagonists as Antipruritics......Page 337
32. Cutaneous Nerve Stimulation in Treatment of Localized Itch......Page 346
33. Psychosomatic Aspects of Pruritus......Page 353
34. On Psychological Factors Affecting Reports of Itch Perception......Page 360
35. Itching as a Focus of Mental Disturbance......Page 377
Index......Page 384
