The book provides a detailed, up-to-date account of the basics, the technology, and the clinical use of ion beams for radiation therapy. Theoretical background, technical components, and patient treatment schemes are delineated by the leading experts that helped to develop this field from a research niche to its current highly sophisticated and powerful clinical treatment level used to the benefit of cancer patients worldwide.
Rather than being a side-by-side collection of articles, this book consists of related chapters. It is a common achievement by 76 experts from around the world. Their expertise reflects the diversity of the field with radiation therapy, medical and accelerator physics, radiobiology, computer science, engineering, and health economics. The book addresses a similarly broad audience ranging from professionals that need to know more about this novel treatment modality or consider to enter the field of ion beam therapy as a researcher. However, it is also written for the interested public and for patients who might want to learn about this treatment option.
Author(s): James M. Slater (auth.), Ute Linz (eds.)
Series: Biological and Medical Physics, Biomedical Engineering 320
Edition: 1
Publisher: Springer-Verlag Berlin Heidelberg
Year: 2012
Language: English
Pages: 729
City: Berlin, Heidelberg
Tags: Medical and Radiation Physics;Radiotherapy;Nuclear Medicine;Biomedical Engineering;Energy, general;Cancer Research
Front Matter....Pages i-xxxv
Front Matter....Pages 1-1
From X-Rays to Ion Beams: A Short History of Radiation Therapy....Pages 3-16
The Place of Ion Beams in Clinical Applications....Pages 17-29
Socio-Economic Aspects of Ion Beam Therapy....Pages 31-41
Front Matter....Pages 43-43
Physical and Biological Rationale for Using Ions in Therapy....Pages 45-59
Early and Late Responses to Ion Irradiation....Pages 61-79
The Impact of Radiation Quality on Cure Rate....Pages 81-93
Front Matter....Pages 95-95
Monte Carlo Methods for Dose Calculations....Pages 97-116
Modeling Heavy Ion Radiation Effects....Pages 117-133
Preclinical Radiobiology and Predictive Assays....Pages 135-145
Front Matter....Pages 147-147
Ocular Proton Therapy Centers....Pages 149-177
Clinical Indications for Carbon Ion Radiotherapy and Radiation Therapy with Other Heavier Ions....Pages 179-192
Skull Base Tumors....Pages 193-205
Proton Therapy for Thoracoabdominal Tumors....Pages 207-222
Carbon Ion Radiotherapy for Peripheral Stage I Non-Small Cell Lung Cancer....Pages 223-236
Ion Beam Therapy for Gynecological Tumors....Pages 237-251
Is Prostate Cancer a Good Candidate for Ion Beam Therapy?....Pages 253-276
Rationale for Proton Therapy in Pediatric Malignancies....Pages 277-286
Tolerance of Normal Tissues to Ion Beam Therapy....Pages 287-309
Design and Implementation of Clinical Trials of Ion Beam Therapy....Pages 311-322
Front Matter....Pages 323-323
Design Criteria for Medical Accelerators....Pages 325-343
Front Matter....Pages 323-323
Shielding and Radiation Protection in Ion Beam Therapy Facilities....Pages 345-359
Commercial Ion Beam Therapy Systems....Pages 361-375
Advantages and Challenges of Superconducting Accelerators....Pages 377-396
Front Matter....Pages 397-397
All-in-One: An Attempt to Integrate the Full Potential of Proton Pencil Beam Scanning in a New Gantry System....Pages 399-415
Beam Spreading Devices....Pages 417-440
Dosimetry Techniques for Ion Beams....Pages 441-455
Control and Safety Systems for Ion Beam Therapy....Pages 457-469
Considerations for an Effective Quality Assurance Program for Proton Therapy....Pages 471-485
Front Matter....Pages 487-487
Imaging and Tumor Localization for Ion Beam Therapy....Pages 489-502
Treatment Planning for Ion Beam Therapy....Pages 503-525
Online Irradiation Control by Means of PET....Pages 527-543
Compensation of Target Motion....Pages 545-558
Industrial Robots for Patient Support....Pages 559-577
Front Matter....Pages 579-579
Twenty Years of Proton Radiation Therapy at Loma Linda University Medical Center....Pages 581-595
The Francis H. Burr Proton Therapy Center....Pages 597-609
HIMAC: A New Start for Heavy Ions....Pages 611-621
A National Action Plan in Japan: From Experimental Studies to Highly Advanced Medical Technology....Pages 623-639
Operational and Training Issues Related to Facility Start-Up....Pages 641-658
Front Matter....Pages 657-657
The Single-Room Ion Beam Facility....Pages 661-672
Smaller – Lighter – Cheaper: New Technological Concepts in Proton Therapy....Pages 673-685
Front Matter....Pages 657-657
New Facilities: Plans and Proposals....Pages 687-701
Future Directions in Ion Beam Therapy....Pages 703-717
Back Matter....Pages 719-729
