Introductory Immunology: Basic Concepts for Interdisciplinary Applications, Second Edition is a completely updated, revised and expanded resource on the immune system as a primary defense for the maintenance of health and homeostasis. The book highlights the components of the human immune system and how they work together to confer protection against pathogenic invaders. It also creates an understanding of the basis for clinical tests and immune therapeutics and their importance in identifying and treating disease states. This updated edition will strengthen the foundation required to understand the placement of immune function within clinical practice, thus allowing a basic platform to define therapeutic treatments.
Key Features
Creates appreciation for the components of the human immune system that work together to confer lifelong protection
Provides core knowledge in immunology to build a foundation to explore mechanisms involved in clinical disease
Breaks down all immunology concepts into manageable, logically digestible building blocks
Geared toward readers without medical, biochemical or cellular expertise
Includes a glossary that provides functional definitions of complex terms
Readership
Researchers, (post) graduates, educated audience interested in immunology. Researchers, graduates, scientific audience outside of his/her area of expertise
Author(s): Jeffrey Actor
Edition: 2nd Edition
Publisher: Academic Press / Elsevier
Year: 2019
Language: English
Commentary: TRUE PDF
Pages: 196
Front Cover......Page 1
Introductory Immunology: Basic Concepts for Interdisciplinary Applications......Page 4
Copyright......Page 5
Dedication......Page 6
Contents......Page 8
Preface......Page 12
Acknowledgments......Page 16
Immune Homeostasis......Page 18
Self versus Nonself......Page 19
Innate and Adaptive Immunity......Page 20
Anatomy of the Immune System......Page 22
Cells of the Immune System......Page 25
First-Line Defenders: The Myeloid Cells......Page 27
Lymphocytes......Page 29
Summary......Page 31
Inflammation......Page 34
Initiation of the Inflammatory Response......Page 36
The Role of Antibodies in Inflammation......Page 37
Biological Functions of Complement......Page 38
Activation and Directed Migration of Leukocytes......Page 39
Pathogen Recognition and Cytokine Signaling......Page 40
Feedback and Adaptation From a Distance......Page 41
Pathological Consequences of the Inflammatory Response......Page 46
Summary......Page 47
B Lymphocytes Produce Antibodies......Page 48
Structural Characteristics of Immunoglobulins......Page 49
Immunoglobulin Nomenclature......Page 52
IgM......Page 53
IgG......Page 54
IgA......Page 55
Kinetics of Antibody Response......Page 56
Gene Recombination......Page 57
Activation and Differentiation of B Cells......Page 59
Summary......Page 60
T Lymphocytes: Specific and Long-Lasting Immunity......Page 62
T-Cell Development......Page 63
The HLA Locus......Page 66
MHC Class I......Page 67
T Lymphocyte Functions......Page 69
CD4+ T-Helper Cells......Page 71
Events Involved in T Lymphocyte Activation......Page 72
Role of T Cells in B-Cell Activation......Page 74
CD8+ T Cells......Page 75
γδ T Cells......Page 76
Natural Killer T (NKT) Cells......Page 77
Summary......Page 78
Immune Homeostasis and Pathogenic Organisms......Page 80
Major Immune Defense Mechanisms Against Pathogens......Page 81
Inflammatory Barriers......Page 82
Bacterial Infections......Page 83
Microbial Motifs Detected Through Pattern-Recognition Receptors......Page 86
Mycobacterial Infections......Page 88
Viral Infections......Page 90
Human Immunodeficiency Virus......Page 92
Parasitic Infections (Helminths)......Page 93
Fungal Infections......Page 94
Evasion of Immune Response......Page 95
Summary......Page 96
Immunodeficiency Disorders......Page 98
Innate Deficiencies......Page 99
Complement Disorders......Page 100
Adaptive Immune Disorders......Page 101
Common Variable Immunodeficiency......Page 102
Wiskott-Aldrich Syndrome......Page 103
Treatment of Immunodeficiency Diseases......Page 104
Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS)......Page 106
Summary......Page 107
Homeostasis, Immune Regulation, and Autoimmunity......Page 108
Tolerance to Self......Page 109
Etiology of Autoimmune Disease......Page 111
Role of Autoantibodies and Self-Reactive T Lymphocytes in Autoimmune Disorders......Page 115
Laboratory Tests for Autoimmunity......Page 117
Targeted Therapeutics......Page 118
Summary......Page 119
Hypersensitive Disorders......Page 120
Type I Hypersensitivity: Immunoglobulin E (IgE)-Mediated Immediate Hypersensitivity......Page 121
Type II Hypersensitivity: Antibody-Mediated Cytotoxic Hypersensitivity......Page 122
Type III Hypersensitivity: Immune Complex-Mediated Hypersensitivity......Page 124
Type IV Hypersensitivity: Delayed-Type (Cell-Mediated) Hypersensitivity......Page 125
Summary......Page 127
Principles of Vaccination......Page 128
Basic Concepts of Protective Immunization......Page 129
Age and Timing of Immunizations......Page 131
Passive Immunization......Page 135
Therapeutic Uses of Immunoglobulins......Page 136
Summary......Page 137
Understanding Immune Defenses Against Cancers......Page 140
Tumor Antigens......Page 141
Natural Killer (NK) Cells and Innate Response to Tumor Cells......Page 142
Adaptive Response to Tumor Cells......Page 143
Tumors of the Immune System......Page 145
Immunodiagnosis and Immunotherapy......Page 146
Summary......Page 148
Transplantation Defined......Page 150
Tissue Histocompatibility......Page 151
Human Leukocyte Antigens......Page 152
Allograft Rejection......Page 153
Accelerated Rejection......Page 154
Graft-Versus-Host Disease (GVHD)......Page 155
Pretransplantation Histocompatibility Evaluation......Page 156
Immunosuppressive Drugs to Prevent Allograft Rejection......Page 157
Immunosuppressive Therapy......Page 158
Summary......Page 159
Antibody-Antigen Reactions......Page 160
Affinity......Page 161
Secondary Manifestations of Antibody-Antigen Binding......Page 162
Solid-Phase Precipitation Assays......Page 165
Radial Immunodiffusion......Page 166
Lateral Flow......Page 167
Western Blot......Page 168
Enzyme-Linked Immunoadsorbent Assay (ELISA)......Page 169
Immunohistochemistry......Page 171
Fluorescence-Activated Cell Sorting (FACS) Analysis......Page 172
Assays to Determine Immune Function......Page 174
Complement Fixation Test......Page 175
Monoclonal Antibodies......Page 176
Microarrays......Page 177
Summary......Page 178
Glossary......Page 180
Index......Page 188
Back Cover......Page 196
