As the tools and techniques of structural biophysics assume greater roles in biological research and a range of application areas, learning how proteins behave becomes crucial to understanding their connection to the most basic and important aspects of life. With more than 350 color images throughout, Introduction to Proteins: Structure, Function, and Motion presents a unified, in-depth treatment of the relationship between the structure, dynamics, and function of proteins. Taking a structural–biophysical approach, the authors discuss the molecular interactions and thermodynamic changes that transpire in these highly complex molecules. The text incorporates various biochemical, physical, functional, and medical aspects. It covers different levels of protein structure, current methods for structure determination, energetics of protein structure, protein folding and folded state dynamics, and the functions of intrinsically unstructured proteins. The authors also clarify the structure–function relationship of proteins by presenting the principles of protein action in the form of guidelines. This comprehensive, color book uses numerous proteins as examples to illustrate the topics and principles and to show how proteins can be analyzed in multiple ways. It refers to many everyday applications of proteins and enzymes in medical disorders, drugs, toxins, chemical warfare, and animal behavior. Downloadable questions for each chapter are available at CRC Press Online.
Author(s): Amit Kessel; Nir Ben-Tal
Series: Chapman & Hall/CRC mathematical and computational biology series (Unnumbered)
Publisher: CRC Press
Year: 2011
Language: English
Pages: xxvii, 626 p.. (some col.) ; 27 cm
City: Boca Raton, FL
Tags: Биологические дисциплины;Биохимия;Биохимия белков;
Content: Introduction THE IMPORTANCE OF PROTEINS IN LIVING ORGANISMS STRUCTURAL COMPLEXITY AND ITS EFFECT ON PROTEIN FUNCTION NON-COVALENT INTERACTIONS BETWEEN ATOMS IN BIOMOLECULES Protein Structure INTRODUCTION PRIMARY STRUCTURE SECONDARY STRUCTURE TERTIARY STRUCTURE QUATERNARY STRUCTURE POST-TRANSLATIONAL MODIFICATIONS Methods of Structure Determination and Prediction INTRODUCTION DIFFRACTION/SCATTERING METHODS SPECTROSCOPIC METHODS COMPUTATIONAL METHODS FOR STRUCTURE PREDICTION CONCLUSIONS THE PROTEIN DATA BANK (PDB) Energetics and Protein Stability BASIC PRINCIPLES OF THERMODYNAMICS PROTEIN STABILITY AND THE FORCES INVOLVED PROTEIN DENATURATION AND ADAPTATION TO EXTREME CONDITIONS STABILITY ENHANCEMENT OF INDUSTRIAL ENZYMES USING PROTEIN ENGINEERING Protein Structural Dynamics INTRODUCTION PROTEIN FOLDING FOLDED STATE DYNAMICS METHODS FOR STUDYING PROTEIN DYNAMICS Non-Globular Proteins INTRODUCTION FIBROUS PROTEINS INTRINSICALLY UNSTRUCTURED PROTEINS Membrane Proteins INTRODUCTION STRUCTURE AND ORGANIZATION OF BIOLOGICAL MEMBRANES PRINCIPLES OF MEMBRANE PROTEIN STRUCTURE PROTEIN-MEMBRANE INTERACTIONS STRUCTURE-FUNCTION RELATIONSHIP IN MEMBRANE PROTEINS AND PEPTIDES Protein-Ligand Interactions INTRODUCTION THEORIES ON PROTEIN-LIGAND BINDING PROTEIN-LIGAND BINDING ENERGETICS THE LIGAND-BINDING SITE PROTEIN-PROTEIN INTERACTIONS PROTEIN-LIGAND INTERACTIONS IN DRUG ACTION AND DESIGN Index A Summary and References appear at the end of each chapter.
Abstract:
Providing a description of the relationship between protein structure, function, and dynamics, this book adopts an energy-oriented approach to discuss structural-biophysical aspects, molecular interactions, and thermodynamic changes that transpire in proteins. It describes experimental and computational methods for studying structure and dynamics. Read more...
