Inorganic Biochemistry of Iron Metabolism: From Molecular Mechanisms to Clinical Consequences, Second Edition

Iron is of fundamental importance for the growth, development and well being of almost all living organisms. Multiple biological systems have been developed for the uptake, utilisation, storage and homeostasis of iron in microbes, plants and mammals. e.g. Both iron deficiency and iron overload are found extensively in man: the intimate links between iron and oxidative stress are associated with a wide range of pathologies; iron has a well established role in infections by a wide range of microorganisms and parasites; there is a close link between iron requirements and cellular division with implications for cancers and other metals such as copper and zinc are closely linked with iron metabolism.

The first edition of this book was published in 1991. Since then the extensive impact of molecular cell biology on the field of iron biochemistry has opened new horizons in our understanding of the transport and storage of iron and of its homeostasis. The explosive use of molecular biological techniques applied to cellular biology of iron metabolism has resulted in a rapid expansion in the literature which has led to the need for this second edition.

This second edition also:

• Introduces many illustrations and colour photos to make the basic concepts far clearer
• Includes new chapters on iron and cell division and interactions of iron with other metals - particularly copper and zinc
• Provides additional anecdotes
• Incorporates an extensive and up-to-date bibliography

Content:
Chapter 1 Solution Chemistry of Iron in Biological Media (pages 1–15):
Chapter 2 The Importance of Iron for Biological Systems (pages 17–48):
Chapter 3 Microbial Iron Uptake (pages 49–81):
Chapter 4 Iron Uptake by Plants and Yeast (pages 83–105):
Chapter 5 Cellular Iron Uptake in Mammals (pages 107–131):
Chapter 6 Intracellular Iron Storage and Biomineralization (pages 133–165):
Chapter 7 Intracellular Iron Metabolism and Cellular Iron Homeostasis (pages 167–190):
Chapter 8 Iron Absorption in Mammals with Particular Reference to Man (pages 191–206):
Chapter 9 Pathophysiology of Iron Deficiency and Iron Overload in Man (pages 207–233):
Chapter 10 Iron and Oxidative Stress (pages 235–257):
Chapter 11 Iron and Infection (pages 259–284):
Chapter 12 Interactions between Iron and Other Metals (pages 285–312):
Chapter 13 Concluding Remarks (pages 313–319):