Inflammatory breast cancer is the most deadly subtype of breast cancer because it can spread to other organs despite of multidisciplinary approach. However, the molecular characteristic of this aggressive disease is yet to be established. This book is the one of the few textbooks that summarizes the latest information dated to inflammatory breast cancer. The uniqueness of this book is that it has summarized the latest molecular and mechanistic findings, which may lead to novel diagnostic tool or therapeutic approach to fight this deadly disease.
Author(s): Naoto T. Ueno M.D., Ph.D., F.A.C.P. (auth.), Naoto T. Ueno, Massimo Cristofanilli (eds.)
Edition: 1
Publisher: Springer Netherlands
Year: 2012
Language: English
Pages: 294
Tags: Biomedicine general; Cancer Research; Oncology
Front Matter....Pages i-vi
Introduction: Why IBC Now?....Pages 1-2
Epidemiology of Inflammatory Breast Cancer....Pages 3-9
Clinical Aspect of Inflammatory Breast Cancer: Diagnosis, Criteria, Controversy....Pages 11-19
Inflammatory Breast Cancer Registry....Pages 21-26
Pathology: Histomorphometrical Features of IBC – Angiogenesis, Lymphangiogenesis, and Tumor Emboli....Pages 27-51
Imaging for the Diagnosis and Staging of IBC....Pages 53-66
Surgical Therapy for Inflammatory Breast Cancer....Pages 67-73
Radiation Therapy for Inflammatory Breast Cancer....Pages 75-84
Systemic and Targeted Therapy....Pages 85-99
Inflammatory Breast Cancer: Chemotherapy of Metastatic Disease....Pages 101-120
The Role of the Multidisciplinary Team in Inflammatory Breast Cancer....Pages 121-126
High-Dose Chemotherapy with Autologous Hematopoietic Stem Cell Transplantation in Inflammatory Breast Cancer....Pages 127-138
Models of Inflammatory Breast Cancer....Pages 139-150
Signaling Pathways in Inflammatory Breast Cancer....Pages 151-160
Molecules That Drive the Invasion and Metastasis of Inflammatory Breast Cancer....Pages 161-184
Inflammatory Mediators as Therapeutic Targets for Inflammatory Breast Cancer....Pages 185-205
Immunology of Inflammatory Breast Cancer....Pages 207-224
Angiogenesis and Lymphangiogenesis in IBC: Insights from a Genome-Wide Gene Expression Profiling Study....Pages 225-242
Microarray Analysis Identifies an Expression Signature for Inflammatory Breast Cancer....Pages 243-258
Cell Gene Expression Signatures in Inflammatory Breast Cancer....Pages 259-270
The Effect of Systemic Chemotherapy on Minimal Residual Disease in the Blood and Bone Marrow of Patients with Inflammatory Breast Cancer....Pages 271-279
Perspective of Patient Advocacy....Pages 281-290
Back Matter....Pages 291-294
