This volume represents a series of papers presented at the Second International Workshop on HPV Immunology held at the University of Cambridge July 5-7 1993. This Workshop and its predecessor held in Amsterdam in May 1992 were two of the major activities of the European Concerted Action "Immunology of Human Papillomavirus and Vaccine Development". The Concerted Action (CA) was supported by grants from the Commission of the European Communities (EC), the French Association for Cancer Research (ARC) and the European Association for Medical Research (EAMR). Twenty two laboratories throughout Europe and Scandinavia were members of the CA, the objectives of which were to develop collaborations, implement scientific exchanges and co-operate in a collective effort to develop vaccination strategies for HPV. HPV's are ubiquitous pathogens and evidence which has been accumulated over the past decade leaves little doubt that infection with certain HPV types (the so called "oncogenic HPV's" 16, 18 and their relatives) is the major risk factor in the development of cancer of the uterine cervix in women. Since an infectious agent, a virus, is implicated as the main aetiologic factor in this disease, the possibility is raised that if one could prevent HPV infection or treat established infections this would be an effective anti-cancer strategy against what is the commonest cancer in women worldwide.
Author(s): Greg Matlashewski (auth.), Margaret A. Stanley (eds.)
Edition: 1
Publisher: Springer US
Year: 1994
Language: English
Pages: 332
Tags: Immunology; Pathology; Medical Microbiology; Plant Sciences; Animal Anatomy / Morphology / Histology; Microbial Ecology
Front Matter....Pages i-xi
The Antibody Response Against P53 in Cancer Patients....Pages 1-7
Enhanced Production of Wild-Type P53 Inhibits Growth and Differentiation of Normal Foreskin Epithelial Cells but not Cell Lines Containing Human Papillomavirus DNA....Pages 9-14
Detection of Human Papillomavirus, Epstein Barr Virus and Elevated or Mutant P53 Expression in Squamous Cell Carcinoma of the Head and Neck....Pages 15-20
Elevated Levels of the P53 Tumour Suppressor Protein in the Basal Layer of Recurrent Laryngeal Papillomas....Pages 21-24
Expression of the E6 and E7 Genes of Human Papillomaviruses in Tumors of Different Dignity....Pages 25-31
Detection of HPV-16 E2 Protein in Cervical Keratinocytes....Pages 33-38
Evaluation of the Hybrid Capture Assay for Determination of Human Papilloma Virus....Pages 39-43
Utilization of a PCR-Based, Multiple Restriction Endonuclease Digest Technique for Enhanced Detection and Typing of HPV from Clinical Samples....Pages 45-49
A Gene Cassette for High Level Expression of the Li Capsid Protein of HPV-16 in Heterologous Cells....Pages 51-54
Genotyping of Human Papillomavirus (HPV) by Single-Strand Conformational Polymorphism (SSCP)....Pages 55-58
Human Papillomavirus Infection in Women with Cervical Cancer but without Cytological Abnormalities in the Preceding Years....Pages 59-62
HPV Infection and Carcinomas of the Larynx....Pages 63-69
Perinatal Transmission and Persistence of the Cancer Associated Human Papillomaviruses....Pages 71-74
HPV-DNA on Colpocytological Smears from HIV Positive Females....Pages 75-80
Humoral Immune Response to Genital Human Papillomavirus Infections....Pages 81-84
HPV16 Antibodies in Cervical Cancer Patients and Healthy Control Women....Pages 85-90
Prevalence of Antibodies Against Defined HPV Epitopes Among Incident Cases of Cervical Neoplasia: Current Status and Concepts....Pages 91-101
Serological Response to HPV16 Infection....Pages 103-107
Detection of Antibodies to LI, L2, and E4 Gene Products of Human Papillomavirus Types 6, 11, and 16 Among HPV Infected Patients and Controls....Pages 109-111
IgG Antibodies to Human Papillomavirus Type 16 and Serum Retinol May Jointly Protect Against Cervical Neoplasia....Pages 113-118
Prognostic Significance of Antibodies to HPV-16 E7 /E4 Proteins and Fragments of Cytokeratin 19 in Invasive Cervical Carcinoma....Pages 119-123
Development of Serological Assays for Detection of ANTI-HPV-16 E6 and E7 Antibodies....Pages 125-132
Detection by Elisa Test of Antibodies to Human Papillomavirus (HPV) Type 16 E7 Oncoprotein in Patients with Benign or Malignant Papillomas from Skin or Mucosa....Pages 133-138
Seroreactivity to a L2-Derived Synthetic Peptide Correlates with the Number of Surgery-Necessitating Recurrences in Patients with Laryngeal Papillomatosis....Pages 139-145
Comparison of PV Conformational Epitopes Expressed by L1 Proteins in Mammalian (COS) and Insect (SF9) Cells....Pages 147-153
Detection of Class-Specific Antibodies to Baculovirus-Derived Human Papillomavirus Type 16 (HPV-16) Capsid Proteins....Pages 155-160
Evolution of Class I HLA Antigen Presenting Molecules....Pages 161-172
Major Histocompatibility Complex (MHC) Expression and Antigen Presentation in Cervical Cancer....Pages 173-179
Analysis of MHC Class I Expression in HPV 16 Positive Cervical Carcinomas, in Relation to C- MYC Overexpression....Pages 181-188
Immunogenetic Study of Women with HPV Related Cancer of the Uterine Cervix....Pages 189-193
Recurrent Respiratory Papillomatosis (RRP): Enriched HLA DQw3 Phenotype and Decreased Class I MHC Expression....Pages 195-200
HPV 16-Derived Synthetic Peptides with Ability to Upregulate MHC Class I Expression on RMA-S or T2 Cells, as Detected by Enzyme Immunoassay....Pages 201-205
Regulation of MHC Class I, Class II and ICAM-1 Expression by Cytokines and Retinoids in HPV-Harboring Keratinocyte Lines....Pages 207-211
Murine Cytotoxic T Cell Responses to Human Papillomavirus E7 Protein....Pages 213-218
Immune Response to Human Papillomavirus Type 16 E6 Oncoprotein....Pages 219-226
Human Cytotoxic T Cell Epitopes in HPV 11: Relationships between Allele-Specific Motifs, HLA Binding, and Stimulation in Vitro....Pages 227-232
An Immunodominant Region in HPV16.L1 Identified by T Cell Responses in Patients with Cervical Dysplasias....Pages 233-241
Immunological Aspects of Cervical Carcinoma....Pages 243-248
Analysis of Tumour-Infiltrating Lymphocytes in Cervical Carcinoma....Pages 249-253
Lymphocyte-Mediated Natural Cytotoxicity to HPV16 Infected Cervical Keratinocytes....Pages 255-258
Skin Test Reactivity to Papilloma Cells is Long Lasting in Domestic Rabbits after Regression of Cottontail Rabbit Papillomavirus Induced Papillomas....Pages 259-265
Modulation of the DTH Response to HPV 16 E7....Pages 267-274
Fine Characterization of the HPVI6 E7 49-57 Tumor Protective Cytotoxic T Cell Epitope “Rahynivtf”....Pages 275-281
Vaccination of Cattle with L2 Protein Prevents BPV-4 Infection....Pages 283-290
Immune Responses to HPV 16 E7....Pages 291-297
Use of Double Aro Salmonella Mutants to Stably Express HPV16 E7 Protein Epitopes Carried by HBV Core Antigen....Pages 299-303
An Experimental Tetracyclin and Vitamin a Therapy of HPV Infections of the Lower Female Genital Tract....Pages 305-308
Retinoids and Ifnα Synergistically Decrease Tumor Cell-Induced Angiogenesis and Stimulate Lymphocyte Induced Angiogenesis....Pages 309-313
Release of Soluble Tumor Necrosis Factor-α (TNF-α) Receptor by HPV-Associated Neoplastic Cells....Pages 315-320
Back Matter....Pages 321-332
