Immunoendocrinology is a rapidly developing field of research that seeks to understand the intersection of the immune and endocrine systems. Immunoendocrinology: Scientific and Clinical Aspects explores in detail the current knowledge of immunoendocrinology, namely endocrine disorders produced by disorders of immune function. Chapters cover both basic pathophysiology informed by studies of animal models as well as current understanding of multiple related clinical diseases—their pathophysiology, diagnosis, and therapy. Immunoendocrinology: Scientific and Clinical Aspects captures the central role of immunoendocrinologic processes in the pathogenesis of not only type 1 diabetes but in a range of other autoimmune and endocrine disorders.
Author(s): Jean Jasinski, George S. Eisenbarth (auth.), George S. Eisenbarth (eds.)
Series: Contemporary Endocrinology
Edition: 1
Publisher: Humana Press
Year: 2011
Language: English
Pages: 580
Tags: Endocrinology; Immunology; Internal Medicine
Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Primer on Immunoendocrinology....Pages 3-14
Discovering Novel Antigens....Pages 15-39
Developing and Validating High Sensitivity/Specificity Autoantibody Assays....Pages 41-52
Characterizing T-Cell Autoimmunity....Pages 53-68
Metabolic Syndrome and Inflammation....Pages 69-92
Front Matter....Pages 93-93
The Mouse Model of Autoimmune Polyglandular Syndrome Type 1....Pages 95-113
Autoimmune Polyendocrine Syndrome Type I: Man....Pages 115-128
IPEX Syndrome: Clinical Profile, Biological Features, and Current Treatment....Pages 129-142
Autoimmune Polyendocrine Syndrome Type 2: Pathophysiology, Natural History, and Clinical Manifestations....Pages 143-155
Drug-Induced Endocrine Autoimmunity....Pages 157-179
Front Matter....Pages 181-181
The BB Rat....Pages 183-197
Immunopathogenesis of the NOD Mouse....Pages 199-213
Virus-Induced Type 1 Diabetes in the Rat....Pages 215-229
Autoimmune Pathology of Type 1 Diabetes....Pages 231-249
Genetics of Type 1 Diabetes....Pages 251-265
Epidemiology of Type 1 Diabetes....Pages 267-278
Natural History of Type 1 Diabetes....Pages 279-292
Immunotherapy of Type-1 Diabetes: Immunoprevention and Immunoreversal....Pages 293-314
Latent Autoimmune Diabetes in Adults....Pages 315-329
Fulminant Type 1 Diabetes Mellitus....Pages 331-342
Front Matter....Pages 181-181
Insulin Autoimmune Syndrome (Hirata Disease)....Pages 343-367
Lessons from Patients with Anti-Insulin Receptor Autoantibodies....Pages 369-383
Islet and Pancreas Transplantation....Pages 385-398
Addison’s Disease....Pages 399-413
Animal Models of Autoimmune Thyroid Disease....Pages 415-426
Genetics of Thyroid Autoimmunity....Pages 427-442
Immunopathogenesis of Thyroiditis....Pages 443-455
Immunopathogenesis of Graves’ Disease....Pages 457-481
Graves’ Ophthalmopathy....Pages 483-500
Hypoparathyroidism....Pages 501-517
Premature Gonadal Insufficiency....Pages 519-534
Celiac Disease and Intestinal Endocrine Autoimmunity....Pages 535-545
Pituitary Autoimmunity....Pages 547-567
Back Matter....Pages 569-579
