Hydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies

Covers H₂S interactions, methods of detection and delivery in biological environments, and a wide range of applications

Research on hydrogen sulfide (H₂S) spans diverse disciplines including chemistry, biology, and physiology. In recent years, new materials and approaches have been developed to deliver H₂S and related reactive sulfur species in various clinical contexts. Although many biological pathways involving H₂S are complex, all are governed by fundamental chemical interactions between reactive sulfur species and other molecular entities.

Hydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies provides the foundation required for understanding the fundamental chemical biology of H₂S while highlighting the compound’s therapeutic potential and medicinal applications. This book covers key aspects of H₂S chemical biology, including the fundamental chemistry of reactive sulfur species; the measurement, detection, and delivery of H₂S in biological environments; and the therapeutic and medicinal uses of exogenous H₂S delivery in various pharmacologically relevant systems. Throughout the text, editor Michael Pluth and chapter contributors discuss the opportunities and future of the multidisciplinary field.

• Provides approaches for delivering H₂S with relevance to biological and therapeutic applications
• Describes complex interactions of H₂S with bioinorganic complexes and reactive sulfur, nitrogen, and oxygen species
• Summarizes advances in available tools to detect, measure, and modulate H₂S levels in biological environments, such as real-time methods for H₂S fluorescence imaging in live cell and animal systems
• Helps readers understand known systems and make connections to new and undiscovered pathways and mechanisms of action
• Includes in-depth case studies of different systems in which H₂S plays an important role

Hydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies is an important source of current knowledge for researchers, academics, graduate students, and industrial scientists in the fields of redox biology, hydrogen sulfide research, and medicinal chemistry of small biological molecules.