Hormonal carcinogenesis is an important and controversial area of current research. In addition to accelerating existing cancers, can hormones play the role of primary carcinogens? How do genetic factors influence hormone-related cancer risk? Hormones, Genes, and Cancer addresses these questions. Over the past few decades, cancer research has focused on external environmental causes(e.g., tobacco smoke, viruses, asbestos). With the advent of new genetic sequencing techniques, we are just now beginning to understand how the body's internal environment(i.e., the hormones and growth factors that determine normal development) influences cancer etiology and prevention. From molecular insights to clinical analyses, this volume provides state-of-the-art information on the complex interactions between hormones and genes and cancer. The epidemiology and molecular endocrinology of prostate, breast, uterine, ovarian and testicular cancer are detailed in this timely treatise.
Author(s): Brian E. Henderson, Bruce Ponder, Ronald K. Ross
Edition: 1
Publisher: Oxford University Press, USA
Year: 2001
Language: English
Pages: 467
Contents......Page 10
Contributors......Page 12
1. Introduction and Background......Page 18
2. Biosynthesis, Transport, and Metabolism of Steroid Hormones......Page 29
3. The Nuclear Receptor Superfamily......Page 55
4. Genomic Approaches to the Genetics of Hormone-Responsive Cancer......Page 116
5. Breast Cancer: Epidemiology and Molecular Endocrinology......Page 137
6. The Impact of Exogenous Hormone Use on Breast Cancer Risk......Page 156
7. An Overview of Genetic Predisposition and the Search for Predisposing Genes for Breast Cancer......Page 174
8. Estrogen Biosynthesis Genes: P-450 Aromatase......Page 186
9. Estrogen Metabolism Genes: HSD17B1 and HSD17B2......Page 198
10. Breast Cancer: Intervention in BRCA1 and BRCA2 Families......Page 216
11. Implications of Hormones and Hormonal Risk Factors on Screening Strategies......Page 227
12. Hormonal Chemoprevention with Tamoxifen and Selective Estrogen Receptor Modulators......Page 235
13. Other Hormonal Prevention Strategies......Page 265
14. Progression from Hormone-Dependent to Hormone-Independent Breast Cancer......Page 272
15. Prostate Cancer: Epidemiology and Molecular Endocrinology......Page 290
16. Androgen Receptor Signaling in Prostate Cancer......Page 305
17. Hereditary Prostate Cancer: The Search for Major Genes and the Role of Genes Involved in Androgen Action......Page 333
18. Androgen-Independent Prostate Cancer Progression: Mechanistic Insights......Page 348
19. Hormonal Therapies for Prostate Cancer......Page 360
20. Endometrial Cancer: Epidemiology and Molecular Endocrinology......Page 388
21. Ovarian Cancer: Epidemiology and Molecular Endocrinology......Page 415
22. Testicular Cancer: Epidemiology and Molecular Endocrinology......Page 430
A......Page 454
B......Page 455
D......Page 457
E......Page 458
G......Page 459
H......Page 460
K......Page 461
M......Page 462
O......Page 463
P......Page 464
R......Page 465
T......Page 466
Z......Page 467
