Millions of people are now successfully using hormone antagonists for the treatment of endocrine-dependent cancers. In Hormone Therapy in Breast and Prostate Cancer, many of today's leading researchers and clinicians describe the principles underlying these targeted treatments, assess the actions of new and established agents, and illustrate the new applications of hormonal chemoprevention for breast cancer. Topics range from preclinical and clinical antiestrogens to the inhibition of estrogen synthesis and the effects of androgen withdrawal. A wide variety of proven and new agents are discussed-antiestrogens, including aromatase inhibitors (anastrozole, letrozole, and others), SERMs (tamoxifen, raloxifene, and others), and such antiandrogenic strategies as goserelin and bicalutamide.
Unique in its synthesis, Hormone Therapy in Breast and Prostate Cancer offers medical and surgical oncologists, urologists, physicians, and clinical pharmacologists a sound basis for understanding targeted treatments of breast and prostate cancers, and provides a well-proven model for developing powerful new cancer therapeutics.
Author(s): V. Craig Jordan, Barrington J.A. Furr (auth.), V. Craig Jordan, Barrington J.A. Furr (eds.)
Series: Cancer Drug Discovery and Development
Edition: 1
Publisher: Humana Press
Year: 2009
Language: English
Pages: 420
Tags: Oncology; Cancer Research; Pharmacology/Toxicology
Front Matter....Pages I-XVI
Front Matter....Pages 1-1
An Introduction to the Regulation of Sex Steroids for the Treatment of Cancer....Pages 1-13
Front Matter....Pages 15-15
Antiestrogens and the Cell Cycle....Pages 17-45
Drug Resistance to Antiestrogens....Pages 47-68
Mechanisms of Liver Carcinogenesis by Antiestrogens....Pages 69-81
The Effects of Triphenylethylene Antiestrogens on Parameters of Multistage Hepatocarcinogenesis in the Rat....Pages 83-131
Preclinical Studies of Raloxifene and Related Compounds....Pages 133-159
Pure Antiestrogens....Pages 161-181
Front Matter....Pages 183-183
Tamoxifen for the Treatment of Breast Cancer....Pages 185-193
Clinical Utility of New Antiestrogens....Pages 195-212
Breast-Cancer Prevention with Antiestrogens....Pages 213-231
Front Matter....Pages 233-233
Aromatase Inhibitors....Pages 235-263
Clinical Utility of Aromatase Inhibitors....Pages 265-291
LH-RH Agonists for the Treatment of Breast Cancer....Pages 293-308
Front Matter....Pages 309-309
Molecular Action of Androgens....Pages 311-324
Steroidal Antiandrogens....Pages 325-346
Nonsteroidal Antiandrogens....Pages 347-368
LH-RH Agonist Role in Prostate Cancer Management....Pages 369-382
Front Matter....Pages 383-383
Recent Progress in Breast Cancer Research....Pages 385-408
Back Matter....Pages 409-420
